| Full name: MAX dimerization protein 1 | Alias Symbol: MAD1|bHLHc58 | ||
| Type: protein-coding gene | Cytoband: 2p13.3 | ||
| Entrez ID: 4084 | HGNC ID: HGNC:6761 | Ensembl Gene: ENSG00000059728 | OMIM ID: 600021 |
| Drug and gene relationship at DGIdb | |||
Expression of MXD1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MXD1 | 4084 | 228846_at | -1.9895 | 0.0724 | |
| GSE20347 | MXD1 | 4084 | 206877_at | -2.4509 | 0.0000 | |
| GSE23400 | MXD1 | 4084 | 206877_at | -2.2213 | 0.0000 | |
| GSE26886 | MXD1 | 4084 | 226275_at | -3.7540 | 0.0000 | |
| GSE29001 | MXD1 | 4084 | 206877_at | -3.1328 | 0.0000 | |
| GSE38129 | MXD1 | 4084 | 206877_at | -2.0022 | 0.0000 | |
| GSE45670 | MXD1 | 4084 | 228846_at | -0.8653 | 0.0291 | |
| GSE53622 | MXD1 | 4084 | 135219 | -1.7802 | 0.0000 | |
| GSE53624 | MXD1 | 4084 | 135219 | -2.1975 | 0.0000 | |
| GSE63941 | MXD1 | 4084 | 228846_at | 0.3326 | 0.7485 | |
| GSE77861 | MXD1 | 4084 | 226275_at | -1.2904 | 0.0128 | |
| GSE97050 | MXD1 | 4084 | A_23_P408094 | -0.7804 | 0.1733 | |
| SRP007169 | MXD1 | 4084 | RNAseq | -3.9285 | 0.0000 | |
| SRP008496 | MXD1 | 4084 | RNAseq | -4.0422 | 0.0000 | |
| SRP064894 | MXD1 | 4084 | RNAseq | -3.2051 | 0.0000 | |
| SRP133303 | MXD1 | 4084 | RNAseq | -2.3061 | 0.0000 | |
| SRP159526 | MXD1 | 4084 | RNAseq | -3.3871 | 0.0000 | |
| SRP193095 | MXD1 | 4084 | RNAseq | -2.8852 | 0.0000 | |
| SRP219564 | MXD1 | 4084 | RNAseq | -2.4857 | 0.0062 | |
| TCGA | MXD1 | 4084 | RNAseq | -0.0028 | 0.9804 |
Upregulated datasets: 0; Downregulated datasets: 15.
Survival by MXD1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MXD1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MXD1 | 4084 | 11 | 1 | 18 | |
| GSE20123 | MXD1 | 4084 | 11 | 1 | 18 | |
| GSE43470 | MXD1 | 4084 | 3 | 0 | 40 | |
| GSE46452 | MXD1 | 4084 | 2 | 3 | 54 | |
| GSE47630 | MXD1 | 4084 | 7 | 0 | 33 | |
| GSE54993 | MXD1 | 4084 | 0 | 6 | 64 | |
| GSE54994 | MXD1 | 4084 | 12 | 1 | 40 | |
| GSE60625 | MXD1 | 4084 | 0 | 3 | 8 | |
| GSE74703 | MXD1 | 4084 | 3 | 0 | 33 | |
| GSE74704 | MXD1 | 4084 | 9 | 1 | 10 | |
| TCGA | MXD1 | 4084 | 36 | 2 | 58 |
Total number of gains: 94; Total number of losses: 18; Total Number of normals: 376.
Somatic mutations of MXD1:
Generating mutation plots.
Highly correlated genes for MXD1:
Showing top 20/1588 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MXD1 | CYSRT1 | 0.908735 | 6 | 0 | 6 |
| MXD1 | GDPD3 | 0.903361 | 11 | 0 | 11 |
| MXD1 | VSIG10L | 0.890499 | 7 | 0 | 7 |
| MXD1 | GYS2 | 0.88694 | 10 | 0 | 10 |
| MXD1 | ECM1 | 0.881666 | 12 | 0 | 11 |
| MXD1 | SH3GL1 | 0.874264 | 10 | 0 | 10 |
| MXD1 | ENDOU | 0.872573 | 11 | 0 | 11 |
| MXD1 | TMPRSS11E | 0.872391 | 11 | 0 | 11 |
| MXD1 | IL36A | 0.871746 | 11 | 0 | 11 |
| MXD1 | EVPL | 0.871238 | 11 | 0 | 11 |
| MXD1 | CRCT1 | 0.868112 | 12 | 0 | 11 |
| MXD1 | C18orf25 | 0.866601 | 10 | 0 | 10 |
| MXD1 | FLG | 0.865368 | 11 | 0 | 11 |
| MXD1 | ZNF185 | 0.863921 | 12 | 0 | 12 |
| MXD1 | BNIPL | 0.862673 | 7 | 0 | 7 |
| MXD1 | PADI1 | 0.861352 | 8 | 0 | 8 |
| MXD1 | PSCA | 0.860763 | 8 | 0 | 8 |
| MXD1 | SCEL | 0.858282 | 12 | 0 | 11 |
| MXD1 | KRT78 | 0.85642 | 7 | 0 | 7 |
| MXD1 | EPS8L2 | 0.854544 | 11 | 0 | 11 |
For details and further investigation, click here
