| Full name: synaptic vesicle glycoprotein 2A | Alias Symbol: SV2|KIAA0736 | ||
| Type: protein-coding gene | Cytoband: 1q21.2 | ||
| Entrez ID: 9900 | HGNC ID: HGNC:20566 | Ensembl Gene: ENSG00000159164 | OMIM ID: 185860 |
| Drug and gene relationship at DGIdb | |||
Expression of SV2A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SV2A | 9900 | 203069_at | -0.0003 | 0.9994 | |
| GSE20347 | SV2A | 9900 | 203069_at | 0.6049 | 0.0027 | |
| GSE23400 | SV2A | 9900 | 203069_at | 0.0717 | 0.3373 | |
| GSE26886 | SV2A | 9900 | 203069_at | 1.0267 | 0.0003 | |
| GSE29001 | SV2A | 9900 | 203069_at | 0.3809 | 0.3474 | |
| GSE38129 | SV2A | 9900 | 203069_at | 0.4654 | 0.0929 | |
| GSE45670 | SV2A | 9900 | 203069_at | -0.0821 | 0.7887 | |
| GSE53622 | SV2A | 9900 | 95445 | -0.0832 | 0.3440 | |
| GSE53624 | SV2A | 9900 | 95445 | -0.4117 | 0.0005 | |
| GSE63941 | SV2A | 9900 | 203069_at | -2.0309 | 0.0104 | |
| GSE77861 | SV2A | 9900 | 203069_at | 0.0080 | 0.9771 | |
| GSE97050 | SV2A | 9900 | A_23_P23728 | 0.0721 | 0.8438 | |
| SRP007169 | SV2A | 9900 | RNAseq | 3.7537 | 0.0048 | |
| SRP064894 | SV2A | 9900 | RNAseq | 0.9960 | 0.0002 | |
| SRP133303 | SV2A | 9900 | RNAseq | 1.0881 | 0.0133 | |
| SRP159526 | SV2A | 9900 | RNAseq | 2.7176 | 0.0000 | |
| SRP219564 | SV2A | 9900 | RNAseq | 0.9900 | 0.0980 | |
| TCGA | SV2A | 9900 | RNAseq | 0.2062 | 0.2904 |
Upregulated datasets: 4; Downregulated datasets: 1.
Survival by SV2A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SV2A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SV2A | 9900 | 15 | 0 | 15 | |
| GSE20123 | SV2A | 9900 | 15 | 0 | 15 | |
| GSE43470 | SV2A | 9900 | 6 | 1 | 36 | |
| GSE46452 | SV2A | 9900 | 2 | 1 | 56 | |
| GSE47630 | SV2A | 9900 | 14 | 0 | 26 | |
| GSE54993 | SV2A | 9900 | 0 | 3 | 67 | |
| GSE54994 | SV2A | 9900 | 15 | 0 | 38 | |
| GSE60625 | SV2A | 9900 | 0 | 0 | 11 | |
| GSE74703 | SV2A | 9900 | 6 | 1 | 29 | |
| GSE74704 | SV2A | 9900 | 7 | 0 | 13 | |
| TCGA | SV2A | 9900 | 34 | 15 | 47 |
Total number of gains: 114; Total number of losses: 21; Total Number of normals: 353.
Somatic mutations of SV2A:
Generating mutation plots.
Highly correlated genes for SV2A:
Showing top 20/271 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SV2A | C9orf153 | 0.695746 | 3 | 0 | 3 |
| SV2A | BEX1 | 0.692977 | 5 | 0 | 4 |
| SV2A | SOST | 0.678382 | 3 | 0 | 3 |
| SV2A | GLI2 | 0.661924 | 4 | 0 | 3 |
| SV2A | RANBP17 | 0.658587 | 3 | 0 | 3 |
| SV2A | NR4A3 | 0.657671 | 3 | 0 | 3 |
| SV2A | CXCL5 | 0.656345 | 3 | 0 | 3 |
| SV2A | NUTM2B | 0.655706 | 3 | 0 | 3 |
| SV2A | IFNL2 | 0.655376 | 3 | 0 | 3 |
| SV2A | FAM131C | 0.650165 | 4 | 0 | 3 |
| SV2A | TMEM151A | 0.64931 | 5 | 0 | 4 |
| SV2A | SOX5 | 0.647889 | 7 | 0 | 5 |
| SV2A | ZNF703 | 0.647152 | 3 | 0 | 3 |
| SV2A | KRTAP10-3 | 0.645093 | 3 | 0 | 3 |
| SV2A | DCHS1 | 0.641519 | 9 | 0 | 8 |
| SV2A | LGALS12 | 0.638758 | 4 | 0 | 4 |
| SV2A | TMEM235 | 0.638429 | 4 | 0 | 4 |
| SV2A | TRO | 0.633223 | 9 | 0 | 7 |
| SV2A | SEZ6 | 0.631222 | 4 | 0 | 3 |
| SV2A | FOXE3 | 0.627776 | 4 | 0 | 3 |
For details and further investigation, click here
