| Full name: SRY-box transcription factor 5 | Alias Symbol: L-SOX5|MGC35153 | ||
| Type: protein-coding gene | Cytoband: 12p12.1 | ||
| Entrez ID: 6660 | HGNC ID: HGNC:11201 | Ensembl Gene: ENSG00000134532 | OMIM ID: 604975 |
| Drug and gene relationship at DGIdb | |||
Expression of SOX5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SOX5 | 6660 | 238009_at | -0.5382 | 0.5859 | |
| GSE20347 | SOX5 | 6660 | 207336_at | 0.1557 | 0.1305 | |
| GSE23400 | SOX5 | 6660 | 207336_at | -0.0623 | 0.0199 | |
| GSE26886 | SOX5 | 6660 | 238009_at | 1.0860 | 0.0345 | |
| GSE29001 | SOX5 | 6660 | 207336_at | 0.0053 | 0.9766 | |
| GSE38129 | SOX5 | 6660 | 207336_at | -0.1065 | 0.4597 | |
| GSE45670 | SOX5 | 6660 | 238009_at | -0.7247 | 0.1751 | |
| GSE53622 | SOX5 | 6660 | 8108 | -2.7562 | 0.0000 | |
| GSE53624 | SOX5 | 6660 | 8108 | -2.5828 | 0.0000 | |
| GSE63941 | SOX5 | 6660 | 238009_at | -1.7958 | 0.0218 | |
| GSE77861 | SOX5 | 6660 | 238009_at | 0.1671 | 0.1083 | |
| GSE97050 | SOX5 | 6660 | A_24_P27234 | -0.6414 | 0.2247 | |
| SRP007169 | SOX5 | 6660 | RNAseq | 1.9703 | 0.0148 | |
| SRP064894 | SOX5 | 6660 | RNAseq | -0.3887 | 0.3053 | |
| SRP133303 | SOX5 | 6660 | RNAseq | -0.3155 | 0.2138 | |
| SRP159526 | SOX5 | 6660 | RNAseq | 1.0645 | 0.0293 | |
| SRP193095 | SOX5 | 6660 | RNAseq | 0.6460 | 0.0037 | |
| SRP219564 | SOX5 | 6660 | RNAseq | 0.2063 | 0.7397 | |
| TCGA | SOX5 | 6660 | RNAseq | -0.6498 | 0.0959 |
Upregulated datasets: 3; Downregulated datasets: 3.
Survival by SOX5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SOX5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SOX5 | 6660 | 10 | 1 | 19 | |
| GSE20123 | SOX5 | 6660 | 10 | 1 | 19 | |
| GSE43470 | SOX5 | 6660 | 9 | 4 | 30 | |
| GSE46452 | SOX5 | 6660 | 10 | 1 | 48 | |
| GSE47630 | SOX5 | 6660 | 15 | 0 | 25 | |
| GSE54993 | SOX5 | 6660 | 1 | 9 | 60 | |
| GSE54994 | SOX5 | 6660 | 11 | 3 | 39 | |
| GSE60625 | SOX5 | 6660 | 0 | 1 | 10 | |
| GSE74703 | SOX5 | 6660 | 9 | 3 | 24 | |
| GSE74704 | SOX5 | 6660 | 6 | 1 | 13 | |
| TCGA | SOX5 | 6660 | 43 | 5 | 48 |
Total number of gains: 124; Total number of losses: 29; Total Number of normals: 335.
Somatic mutations of SOX5:
Generating mutation plots.
Highly correlated genes for SOX5:
Showing top 20/559 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SOX5 | UHRF2 | 0.836918 | 3 | 0 | 3 |
| SOX5 | CASC3 | 0.785113 | 3 | 0 | 3 |
| SOX5 | SFT2D3 | 0.780823 | 3 | 0 | 3 |
| SOX5 | DHRSX | 0.772155 | 3 | 0 | 3 |
| SOX5 | NTNG1 | 0.765882 | 3 | 0 | 3 |
| SOX5 | TSPAN18 | 0.758217 | 4 | 0 | 4 |
| SOX5 | GPR3 | 0.755972 | 3 | 0 | 3 |
| SOX5 | CWF19L2 | 0.752249 | 3 | 0 | 3 |
| SOX5 | ARHGEF33 | 0.74877 | 3 | 0 | 3 |
| SOX5 | DACT2 | 0.745363 | 3 | 0 | 3 |
| SOX5 | CYP21A2 | 0.744391 | 3 | 0 | 3 |
| SOX5 | TMTC1 | 0.741661 | 6 | 0 | 5 |
| SOX5 | ELMO1 | 0.736024 | 3 | 0 | 3 |
| SOX5 | TMEM98 | 0.731684 | 6 | 0 | 5 |
| SOX5 | EBF3 | 0.729762 | 3 | 0 | 3 |
| SOX5 | HSF2 | 0.726896 | 4 | 0 | 4 |
| SOX5 | SHC4 | 0.723315 | 3 | 0 | 3 |
| SOX5 | RFX7 | 0.720953 | 3 | 0 | 3 |
| SOX5 | PIAS2 | 0.71581 | 3 | 0 | 3 |
| SOX5 | SERPINA5 | 0.71392 | 4 | 0 | 3 |
For details and further investigation, click here
