| Full name: interferon lambda 2 | Alias Symbol: IL-28A | ||
| Type: protein-coding gene | Cytoband: 19q13.2 | ||
| Entrez ID: 282616 | HGNC ID: HGNC:18364 | Ensembl Gene: ENSG00000183709 | OMIM ID: 607401 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
IFNL2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04630 | Jak-STAT signaling pathway |
Expression of IFNL2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IFNL2 | 282616 | 1552915_at | -0.0399 | 0.8914 | |
| GSE26886 | IFNL2 | 282616 | 1552915_at | -0.1075 | 0.4346 | |
| GSE45670 | IFNL2 | 282616 | 1552915_at | 0.0840 | 0.4387 | |
| GSE53622 | IFNL2 | 282616 | 43909 | 0.3172 | 0.0003 | |
| GSE53624 | IFNL2 | 282616 | 43909 | 0.3766 | 0.0001 | |
| GSE63941 | IFNL2 | 282616 | 1552915_at | 0.1888 | 0.3098 | |
| GSE77861 | IFNL2 | 282616 | 1552915_at | -0.0586 | 0.7751 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by IFNL2 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of IFNL2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IFNL2 | 282616 | 7 | 4 | 19 | |
| GSE20123 | IFNL2 | 282616 | 7 | 3 | 20 | |
| GSE43470 | IFNL2 | 282616 | 4 | 11 | 28 | |
| GSE46452 | IFNL2 | 282616 | 47 | 2 | 10 | |
| GSE47630 | IFNL2 | 282616 | 9 | 5 | 26 | |
| GSE54993 | IFNL2 | 282616 | 17 | 3 | 50 | |
| GSE54994 | IFNL2 | 282616 | 7 | 9 | 37 | |
| GSE60625 | IFNL2 | 282616 | 9 | 0 | 2 | |
| GSE74703 | IFNL2 | 282616 | 4 | 7 | 25 | |
| GSE74704 | IFNL2 | 282616 | 7 | 1 | 12 | |
| TCGA | IFNL2 | 282616 | 14 | 16 | 66 |
Total number of gains: 132; Total number of losses: 61; Total Number of normals: 295.
Somatic mutations of IFNL2:
Generating mutation plots.
Highly correlated genes for IFNL2:
Showing top 20/208 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IFNL2 | TMEM105 | 0.857068 | 3 | 0 | 3 |
| IFNL2 | WDR87 | 0.81066 | 3 | 0 | 3 |
| IFNL2 | CIB3 | 0.788949 | 3 | 0 | 3 |
| IFNL2 | LINC01352 | 0.788794 | 3 | 0 | 3 |
| IFNL2 | HGFAC | 0.757536 | 3 | 0 | 3 |
| IFNL2 | ACAN | 0.73794 | 3 | 0 | 3 |
| IFNL2 | PDGFB | 0.731203 | 3 | 0 | 3 |
| IFNL2 | LRRC71 | 0.729844 | 3 | 0 | 3 |
| IFNL2 | AK1 | 0.724314 | 3 | 0 | 3 |
| IFNL2 | LINC00523 | 0.719448 | 3 | 0 | 3 |
| IFNL2 | ABHD1 | 0.716122 | 3 | 0 | 3 |
| IFNL2 | TMEM235 | 0.70855 | 4 | 0 | 3 |
| IFNL2 | CC2D2B | 0.705264 | 3 | 0 | 3 |
| IFNL2 | AGXT | 0.703912 | 3 | 0 | 3 |
| IFNL2 | MC3R | 0.701683 | 3 | 0 | 3 |
| IFNL2 | SPTBN4 | 0.699441 | 3 | 0 | 3 |
| IFNL2 | C5orf17 | 0.69907 | 3 | 0 | 3 |
| IFNL2 | VHL | 0.697238 | 3 | 0 | 3 |
| IFNL2 | GNRH2 | 0.696997 | 3 | 0 | 3 |
| IFNL2 | CAMKV | 0.696853 | 3 | 0 | 3 |
For details and further investigation, click here
