| Full name: C-X-C motif chemokine ligand 5 | Alias Symbol: ENA-78 | ||
| Type: protein-coding gene | Cytoband: 4q13.3 | ||
| Entrez ID: 6374 | HGNC ID: HGNC:10642 | Ensembl Gene: ENSG00000163735 | OMIM ID: 600324 |
| Drug and gene relationship at DGIdb | |||
CXCL5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04062 | Chemokine signaling pathway |
Expression of CXCL5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CXCL5 | 6374 | 214974_x_at | 3.3059 | 0.2055 | |
| GSE20347 | CXCL5 | 6374 | 214974_x_at | 0.7587 | 0.0451 | |
| GSE23400 | CXCL5 | 6374 | 214974_x_at | 0.6182 | 0.0002 | |
| GSE26886 | CXCL5 | 6374 | 215101_s_at | -0.1543 | 0.1906 | |
| GSE29001 | CXCL5 | 6374 | 214974_x_at | 1.3972 | 0.0352 | |
| GSE38129 | CXCL5 | 6374 | 214974_x_at | 1.2110 | 0.0028 | |
| GSE45670 | CXCL5 | 6374 | 214974_x_at | 3.1516 | 0.0017 | |
| GSE53622 | CXCL5 | 6374 | 8036 | 0.3409 | 0.0005 | |
| GSE53624 | CXCL5 | 6374 | 8036 | 0.1687 | 0.1519 | |
| GSE63941 | CXCL5 | 6374 | 214974_x_at | -4.0580 | 0.0000 | |
| GSE77861 | CXCL5 | 6374 | 214974_x_at | 1.5690 | 0.0387 | |
| GSE97050 | CXCL5 | 6374 | A_24_P277367 | 0.1922 | 0.5534 | |
| SRP133303 | CXCL5 | 6374 | RNAseq | 5.9710 | 0.0000 | |
| TCGA | CXCL5 | 6374 | RNAseq | 1.2327 | 0.0014 |
Upregulated datasets: 6; Downregulated datasets: 1.
Survival by CXCL5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CXCL5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CXCL5 | 6374 | 2 | 9 | 19 | |
| GSE20123 | CXCL5 | 6374 | 2 | 9 | 19 | |
| GSE43470 | CXCL5 | 6374 | 0 | 13 | 30 | |
| GSE46452 | CXCL5 | 6374 | 3 | 34 | 22 | |
| GSE47630 | CXCL5 | 6374 | 1 | 19 | 20 | |
| GSE54993 | CXCL5 | 6374 | 7 | 0 | 63 | |
| GSE54994 | CXCL5 | 6374 | 1 | 9 | 43 | |
| GSE60625 | CXCL5 | 6374 | 0 | 0 | 11 | |
| GSE74703 | CXCL5 | 6374 | 0 | 11 | 25 | |
| GSE74704 | CXCL5 | 6374 | 2 | 5 | 13 | |
| TCGA | CXCL5 | 6374 | 19 | 28 | 49 |
Total number of gains: 37; Total number of losses: 137; Total Number of normals: 314.
Somatic mutations of CXCL5:
Generating mutation plots.
Highly correlated genes for CXCL5:
Showing top 20/667 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CXCL5 | PCDH18 | 0.823343 | 3 | 0 | 3 |
| CXCL5 | FAM167B | 0.796997 | 3 | 0 | 3 |
| CXCL5 | GLIS3 | 0.796784 | 3 | 0 | 3 |
| CXCL5 | MTMR9 | 0.789795 | 3 | 0 | 3 |
| CXCL5 | UBE2Z | 0.782061 | 3 | 0 | 3 |
| CXCL5 | NEDD9 | 0.781743 | 3 | 0 | 3 |
| CXCL5 | LYAR | 0.778426 | 3 | 0 | 3 |
| CXCL5 | ANTXR2 | 0.775489 | 3 | 0 | 3 |
| CXCL5 | CPT1A | 0.754287 | 3 | 0 | 3 |
| CXCL5 | TAP2 | 0.75293 | 3 | 0 | 3 |
| CXCL5 | ALPK2 | 0.750975 | 3 | 0 | 3 |
| CXCL5 | TNFRSF19 | 0.74366 | 3 | 0 | 3 |
| CXCL5 | IGFBP5 | 0.742822 | 3 | 0 | 3 |
| CXCL5 | FMOD | 0.737801 | 5 | 0 | 5 |
| CXCL5 | ATG12 | 0.735003 | 3 | 0 | 3 |
| CXCL5 | FANCB | 0.733711 | 3 | 0 | 3 |
| CXCL5 | BAG2 | 0.732509 | 3 | 0 | 3 |
| CXCL5 | CXCL3 | 0.726054 | 10 | 0 | 8 |
| CXCL5 | TMEM140 | 0.725149 | 4 | 0 | 3 |
| CXCL5 | CREBL2 | 0.724334 | 3 | 0 | 3 |
For details and further investigation, click here
