| Full name: sclerostin | Alias Symbol: VBCH|DAND6 | ||
| Type: protein-coding gene | Cytoband: 17q21.31 | ||
| Entrez ID: 50964 | HGNC ID: HGNC:13771 | Ensembl Gene: ENSG00000167941 | OMIM ID: 605740 |
| Drug and gene relationship at DGIdb | |||
SOST involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04310 | Wnt signaling pathway |
Expression of SOST:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SOST | 50964 | 223869_at | 0.9952 | 0.3242 | |
| GSE26886 | SOST | 50964 | 223869_at | 1.0253 | 0.0229 | |
| GSE45670 | SOST | 50964 | 223869_at | 0.9499 | 0.0703 | |
| GSE53622 | SOST | 50964 | 62327 | 2.2109 | 0.0000 | |
| GSE53624 | SOST | 50964 | 62327 | 2.6988 | 0.0000 | |
| GSE63941 | SOST | 50964 | 223869_at | 1.0092 | 0.5452 | |
| GSE77861 | SOST | 50964 | 223869_at | 0.6458 | 0.1124 | |
| GSE97050 | SOST | 50964 | A_23_P118571 | 0.0779 | 0.8341 | |
| TCGA | SOST | 50964 | RNAseq | 5.2090 | 0.0000 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by SOST expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SOST:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SOST | 50964 | 5 | 2 | 23 | |
| GSE20123 | SOST | 50964 | 5 | 2 | 23 | |
| GSE43470 | SOST | 50964 | 1 | 2 | 40 | |
| GSE46452 | SOST | 50964 | 32 | 0 | 27 | |
| GSE47630 | SOST | 50964 | 8 | 1 | 31 | |
| GSE54993 | SOST | 50964 | 3 | 4 | 63 | |
| GSE54994 | SOST | 50964 | 8 | 6 | 39 | |
| GSE60625 | SOST | 50964 | 4 | 0 | 7 | |
| GSE74703 | SOST | 50964 | 1 | 1 | 34 | |
| GSE74704 | SOST | 50964 | 3 | 1 | 16 | |
| TCGA | SOST | 50964 | 23 | 7 | 66 |
Total number of gains: 93; Total number of losses: 26; Total Number of normals: 369.
Somatic mutations of SOST:
Generating mutation plots.
Highly correlated genes for SOST:
Showing top 20/149 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SOST | CASC15 | 0.712027 | 4 | 0 | 3 |
| SOST | CLDN20 | 0.706687 | 4 | 0 | 3 |
| SOST | DLX6-AS1 | 0.685125 | 4 | 0 | 4 |
| SOST | TCTE3 | 0.682555 | 4 | 0 | 3 |
| SOST | SV2A | 0.678382 | 3 | 0 | 3 |
| SOST | LRRC4 | 0.673601 | 3 | 0 | 3 |
| SOST | FBXL18 | 0.662955 | 3 | 0 | 3 |
| SOST | FGF19 | 0.655475 | 5 | 0 | 3 |
| SOST | LINC00942 | 0.654113 | 6 | 0 | 6 |
| SOST | SYPL2 | 0.653891 | 3 | 0 | 3 |
| SOST | MPPED1 | 0.653703 | 4 | 0 | 3 |
| SOST | CRMP1 | 0.651173 | 4 | 0 | 3 |
| SOST | KRTAP19-1 | 0.647847 | 5 | 0 | 4 |
| SOST | MEI1 | 0.646144 | 3 | 0 | 3 |
| SOST | CYP4F11 | 0.644024 | 8 | 0 | 7 |
| SOST | SERPINA9 | 0.643887 | 3 | 0 | 3 |
| SOST | DPF1 | 0.643855 | 4 | 0 | 3 |
| SOST | KIAA0319 | 0.641261 | 8 | 0 | 7 |
| SOST | FREM2 | 0.634216 | 6 | 0 | 3 |
| SOST | HCRTR1 | 0.630065 | 4 | 0 | 3 |
For details and further investigation, click here
