| Full name: carnosine synthase 1 | Alias Symbol: KIAA1394 | ||
| Type: protein-coding gene | Cytoband: 11q13.2 | ||
| Entrez ID: 57571 | HGNC ID: HGNC:29268 | Ensembl Gene: ENSG00000172508 | OMIM ID: 613368 |
| Drug and gene relationship at DGIdb | |||
Expression of CARNS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CARNS1 | 57571 | 228984_at | -0.0319 | 0.9359 | |
| GSE26886 | CARNS1 | 57571 | 228984_at | 0.2516 | 0.0637 | |
| GSE45670 | CARNS1 | 57571 | 228984_at | -0.1123 | 0.2576 | |
| GSE53622 | CARNS1 | 57571 | 56286 | -0.8774 | 0.0000 | |
| GSE53624 | CARNS1 | 57571 | 56286 | -0.7107 | 0.0000 | |
| GSE63941 | CARNS1 | 57571 | 228984_at | 0.3905 | 0.1369 | |
| GSE77861 | CARNS1 | 57571 | 228984_at | -0.0230 | 0.9100 | |
| GSE97050 | CARNS1 | 57571 | A_23_P344884 | -0.2731 | 0.4983 | |
| SRP133303 | CARNS1 | 57571 | RNAseq | -1.0349 | 0.0000 | |
| SRP159526 | CARNS1 | 57571 | RNAseq | -0.6255 | 0.0894 | |
| SRP219564 | CARNS1 | 57571 | RNAseq | -0.8211 | 0.1459 | |
| TCGA | CARNS1 | 57571 | RNAseq | -1.4571 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by CARNS1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CARNS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CARNS1 | 57571 | 9 | 4 | 17 | |
| GSE20123 | CARNS1 | 57571 | 9 | 4 | 17 | |
| GSE43470 | CARNS1 | 57571 | 6 | 1 | 36 | |
| GSE46452 | CARNS1 | 57571 | 13 | 3 | 43 | |
| GSE47630 | CARNS1 | 57571 | 8 | 5 | 27 | |
| GSE54993 | CARNS1 | 57571 | 3 | 1 | 66 | |
| GSE54994 | CARNS1 | 57571 | 13 | 4 | 36 | |
| GSE60625 | CARNS1 | 57571 | 0 | 3 | 8 | |
| GSE74703 | CARNS1 | 57571 | 4 | 0 | 32 | |
| GSE74704 | CARNS1 | 57571 | 7 | 2 | 11 | |
| TCGA | CARNS1 | 57571 | 29 | 8 | 59 |
Total number of gains: 101; Total number of losses: 35; Total Number of normals: 352.
Somatic mutations of CARNS1:
Generating mutation plots.
Highly correlated genes for CARNS1:
Showing top 20/123 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CARNS1 | SYPL2 | 0.791746 | 3 | 0 | 3 |
| CARNS1 | NXNL1 | 0.727785 | 3 | 0 | 3 |
| CARNS1 | TNFSF11 | 0.72568 | 3 | 0 | 3 |
| CARNS1 | HTR3A | 0.715454 | 4 | 0 | 4 |
| CARNS1 | PCSK1N | 0.708267 | 4 | 0 | 4 |
| CARNS1 | NACAD | 0.704661 | 3 | 0 | 3 |
| CARNS1 | TBC1D1 | 0.694793 | 3 | 0 | 3 |
| CARNS1 | BRSK1 | 0.689275 | 3 | 0 | 3 |
| CARNS1 | C22orf23 | 0.678407 | 3 | 0 | 3 |
| CARNS1 | VWA3A | 0.674539 | 3 | 0 | 3 |
| CARNS1 | MAMLD1 | 0.673653 | 3 | 0 | 3 |
| CARNS1 | KRTAP19-1 | 0.667901 | 3 | 0 | 3 |
| CARNS1 | CLSTN3 | 0.660354 | 3 | 0 | 3 |
| CARNS1 | OTUD5 | 0.659856 | 3 | 0 | 3 |
| CARNS1 | GRIK5 | 0.658211 | 5 | 0 | 5 |
| CARNS1 | HNF1B | 0.651784 | 3 | 0 | 3 |
| CARNS1 | MPP3 | 0.650221 | 3 | 0 | 3 |
| CARNS1 | TNXB | 0.647369 | 4 | 0 | 4 |
| CARNS1 | MCF2L | 0.64683 | 4 | 0 | 3 |
| CARNS1 | C6orf15 | 0.646599 | 3 | 0 | 3 |
For details and further investigation, click here
