| Full name: G protein-coupled receptor kinase 4 | Alias Symbol: GPRK4 | ||
| Type: protein-coding gene | Cytoband: 4p16.3 | ||
| Entrez ID: 2868 | HGNC ID: HGNC:4543 | Ensembl Gene: ENSG00000125388 | OMIM ID: 137026 |
| Related drugs: BALANOL... [more] | |||
GRK4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04062 | Chemokine signaling pathway | |
| hsa05032 | Morphine addiction |
Expression of GRK4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GRK4 | 2868 | 241989_at | 0.5569 | 0.2773 | |
| GSE20347 | GRK4 | 2868 | 208365_s_at | -0.0097 | 0.9198 | |
| GSE23400 | GRK4 | 2868 | 208365_s_at | -0.0941 | 0.0186 | |
| GSE26886 | GRK4 | 2868 | 241989_at | 0.3839 | 0.0632 | |
| GSE29001 | GRK4 | 2868 | 208365_s_at | 0.0918 | 0.6789 | |
| GSE38129 | GRK4 | 2868 | 208365_s_at | -0.1379 | 0.1341 | |
| GSE45670 | GRK4 | 2868 | 241989_at | 0.1060 | 0.6458 | |
| GSE53622 | GRK4 | 2868 | 116611 | -0.4215 | 0.0000 | |
| GSE53624 | GRK4 | 2868 | 116611 | -0.1780 | 0.0297 | |
| GSE63941 | GRK4 | 2868 | 241989_at | -1.1710 | 0.0038 | |
| GSE77861 | GRK4 | 2868 | 208365_s_at | 0.0827 | 0.6539 | |
| GSE97050 | GRK4 | 2868 | A_23_P212756 | -0.1900 | 0.5020 | |
| SRP064894 | GRK4 | 2868 | RNAseq | 0.7979 | 0.0065 | |
| SRP133303 | GRK4 | 2868 | RNAseq | -0.2093 | 0.3908 | |
| SRP159526 | GRK4 | 2868 | RNAseq | 0.5287 | 0.2734 | |
| SRP219564 | GRK4 | 2868 | RNAseq | 0.2902 | 0.4406 | |
| TCGA | GRK4 | 2868 | RNAseq | -0.3244 | 0.0005 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by GRK4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GRK4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GRK4 | 2868 | 0 | 16 | 14 | |
| GSE20123 | GRK4 | 2868 | 0 | 16 | 14 | |
| GSE43470 | GRK4 | 2868 | 0 | 17 | 26 | |
| GSE46452 | GRK4 | 2868 | 1 | 36 | 22 | |
| GSE47630 | GRK4 | 2868 | 1 | 19 | 20 | |
| GSE54993 | GRK4 | 2868 | 10 | 0 | 60 | |
| GSE54994 | GRK4 | 2868 | 3 | 12 | 38 | |
| GSE60625 | GRK4 | 2868 | 0 | 0 | 11 | |
| GSE74703 | GRK4 | 2868 | 0 | 13 | 23 | |
| GSE74704 | GRK4 | 2868 | 0 | 8 | 12 | |
| TCGA | GRK4 | 2868 | 7 | 48 | 41 |
Total number of gains: 22; Total number of losses: 185; Total Number of normals: 281.
Somatic mutations of GRK4:
Generating mutation plots.
Highly correlated genes for GRK4:
Showing top 20/169 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GRK4 | B3GAT3 | 0.797095 | 3 | 0 | 3 |
| GRK4 | TSPAN10 | 0.786274 | 3 | 0 | 3 |
| GRK4 | DHRS2 | 0.758944 | 3 | 0 | 3 |
| GRK4 | APCDD1L | 0.731137 | 3 | 0 | 3 |
| GRK4 | NACAD | 0.718586 | 4 | 0 | 4 |
| GRK4 | AQP11 | 0.711518 | 3 | 0 | 3 |
| GRK4 | LUZP1 | 0.702078 | 4 | 0 | 3 |
| GRK4 | TNNC2 | 0.694989 | 3 | 0 | 3 |
| GRK4 | TFAP2E | 0.688145 | 4 | 0 | 3 |
| GRK4 | DAB1 | 0.684689 | 5 | 0 | 4 |
| GRK4 | KRTAP9-9 | 0.684467 | 3 | 0 | 3 |
| GRK4 | EYS | 0.682773 | 3 | 0 | 3 |
| GRK4 | NOX1 | 0.680854 | 3 | 0 | 3 |
| GRK4 | TBC1D1 | 0.679551 | 3 | 0 | 3 |
| GRK4 | PHF1 | 0.678667 | 4 | 0 | 4 |
| GRK4 | SLC2A8 | 0.67515 | 3 | 0 | 3 |
| GRK4 | GPR88 | 0.673964 | 4 | 0 | 4 |
| GRK4 | PDE6C | 0.669778 | 4 | 0 | 3 |
| GRK4 | BEAN1 | 0.668331 | 3 | 0 | 3 |
| GRK4 | MT3 | 0.665791 | 4 | 0 | 4 |
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