| Full name: small integral membrane protein 8 | Alias Symbol: DKFZP586E1923|dJ102H19.2 | ||
| Type: protein-coding gene | Cytoband: 6q15 | ||
| Entrez ID: 57150 | HGNC ID: HGNC:21401 | Ensembl Gene: ENSG00000111850 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of SMIM8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SMIM8 | 57150 | 213312_at | 0.1415 | 0.8083 | |
| GSE20347 | SMIM8 | 57150 | 213312_at | 0.7576 | 0.0002 | |
| GSE23400 | SMIM8 | 57150 | 213314_at | 0.0019 | 0.9619 | |
| GSE26886 | SMIM8 | 57150 | 213312_at | 0.8170 | 0.0019 | |
| GSE29001 | SMIM8 | 57150 | 213312_at | 0.8463 | 0.0001 | |
| GSE38129 | SMIM8 | 57150 | 213312_at | 0.6324 | 0.0000 | |
| GSE45670 | SMIM8 | 57150 | 213312_at | 0.3376 | 0.0779 | |
| GSE53622 | SMIM8 | 57150 | 89934 | -0.2467 | 0.0363 | |
| GSE53624 | SMIM8 | 57150 | 89934 | 0.0571 | 0.6405 | |
| GSE63941 | SMIM8 | 57150 | 213312_at | 1.0845 | 0.0320 | |
| GSE77861 | SMIM8 | 57150 | 213312_at | 0.8259 | 0.0297 | |
| SRP007169 | SMIM8 | 57150 | RNAseq | 1.0146 | 0.0534 | |
| SRP008496 | SMIM8 | 57150 | RNAseq | 0.8178 | 0.0233 | |
| SRP064894 | SMIM8 | 57150 | RNAseq | -0.0717 | 0.5748 | |
| SRP133303 | SMIM8 | 57150 | RNAseq | 0.0904 | 0.6299 | |
| SRP159526 | SMIM8 | 57150 | RNAseq | 0.6478 | 0.0089 | |
| SRP193095 | SMIM8 | 57150 | RNAseq | -0.0721 | 0.5386 | |
| SRP219564 | SMIM8 | 57150 | RNAseq | -0.4135 | 0.3170 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SMIM8 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of SMIM8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SMIM8 | 57150 | 1 | 4 | 25 | |
| GSE20123 | SMIM8 | 57150 | 1 | 3 | 26 | |
| GSE43470 | SMIM8 | 57150 | 3 | 1 | 39 | |
| GSE46452 | SMIM8 | 57150 | 2 | 11 | 46 | |
| GSE47630 | SMIM8 | 57150 | 8 | 6 | 26 | |
| GSE54993 | SMIM8 | 57150 | 3 | 2 | 65 | |
| GSE54994 | SMIM8 | 57150 | 8 | 8 | 37 | |
| GSE60625 | SMIM8 | 57150 | 0 | 1 | 10 | |
| GSE74703 | SMIM8 | 57150 | 3 | 1 | 32 | |
| GSE74704 | SMIM8 | 57150 | 0 | 2 | 18 | |
| TCGA | SMIM8 | 57150 | 5 | 21 | 70 |
Total number of gains: 34; Total number of losses: 60; Total Number of normals: 394.
Somatic mutations of SMIM8:
Generating mutation plots.
Highly correlated genes for SMIM8:
Showing top 20/797 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SMIM8 | MCM3 | 0.723966 | 6 | 0 | 6 |
| SMIM8 | ICE1 | 0.710675 | 5 | 0 | 5 |
| SMIM8 | TYMS | 0.710116 | 3 | 0 | 3 |
| SMIM8 | MSH6 | 0.706335 | 7 | 0 | 6 |
| SMIM8 | MCM7 | 0.705256 | 7 | 0 | 7 |
| SMIM8 | GOLM1 | 0.704979 | 5 | 0 | 5 |
| SMIM8 | RFC4 | 0.702236 | 7 | 0 | 6 |
| SMIM8 | CENPN | 0.700981 | 6 | 0 | 6 |
| SMIM8 | PPFIA1 | 0.692929 | 4 | 0 | 4 |
| SMIM8 | MCM2 | 0.692277 | 7 | 0 | 6 |
| SMIM8 | CKS1B | 0.687525 | 7 | 0 | 7 |
| SMIM8 | UBE2T | 0.681147 | 4 | 0 | 4 |
| SMIM8 | WDR5B | 0.680875 | 5 | 0 | 5 |
| SMIM8 | DVL3 | 0.680467 | 5 | 0 | 5 |
| SMIM8 | APMAP | 0.677464 | 6 | 0 | 6 |
| SMIM8 | STARD7 | 0.676677 | 5 | 0 | 5 |
| SMIM8 | RAD51AP1 | 0.674838 | 7 | 0 | 7 |
| SMIM8 | ECT2 | 0.673112 | 7 | 0 | 6 |
| SMIM8 | MEST | 0.672972 | 6 | 0 | 6 |
| SMIM8 | PARP1 | 0.672522 | 7 | 0 | 6 |
For details and further investigation, click here
