| Full name: multiple PDZ domain crumbs cell polarity complex component | Alias Symbol: MUPP1 | ||
| Type: protein-coding gene | Cytoband: 9p23 | ||
| Entrez ID: 8777 | HGNC ID: HGNC:7208 | Ensembl Gene: ENSG00000107186 | OMIM ID: 603785 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
MPDZ involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04530 | Tight junction |
Expression of MPDZ:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MPDZ | 8777 | 213306_at | -0.7236 | 0.3558 | |
| GSE20347 | MPDZ | 8777 | 213306_at | 0.6030 | 0.0473 | |
| GSE23400 | MPDZ | 8777 | 213306_at | -0.0554 | 0.6951 | |
| GSE26886 | MPDZ | 8777 | 205079_s_at | 0.7184 | 0.0079 | |
| GSE29001 | MPDZ | 8777 | 213306_at | 0.4539 | 0.3110 | |
| GSE38129 | MPDZ | 8777 | 213306_at | 0.1148 | 0.8064 | |
| GSE45670 | MPDZ | 8777 | 213306_at | -1.4700 | 0.0015 | |
| GSE53622 | MPDZ | 8777 | 26445 | -0.1193 | 0.4267 | |
| GSE53624 | MPDZ | 8777 | 26445 | 0.0039 | 0.9711 | |
| GSE63941 | MPDZ | 8777 | 213306_at | -1.5991 | 0.1069 | |
| GSE77861 | MPDZ | 8777 | 205079_s_at | 0.1372 | 0.1522 | |
| GSE97050 | MPDZ | 8777 | A_23_P71598 | -0.5491 | 0.1972 | |
| SRP007169 | MPDZ | 8777 | RNAseq | 4.4528 | 0.0000 | |
| SRP008496 | MPDZ | 8777 | RNAseq | 5.2142 | 0.0000 | |
| SRP064894 | MPDZ | 8777 | RNAseq | 0.2324 | 0.4796 | |
| SRP133303 | MPDZ | 8777 | RNAseq | 0.1037 | 0.7462 | |
| SRP159526 | MPDZ | 8777 | RNAseq | 0.2540 | 0.4639 | |
| SRP193095 | MPDZ | 8777 | RNAseq | 1.1664 | 0.0000 | |
| SRP219564 | MPDZ | 8777 | RNAseq | 0.0459 | 0.9496 | |
| TCGA | MPDZ | 8777 | RNAseq | -0.3206 | 0.0282 |
Upregulated datasets: 3; Downregulated datasets: 1.
Survival by MPDZ expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MPDZ:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MPDZ | 8777 | 2 | 14 | 14 | |
| GSE20123 | MPDZ | 8777 | 2 | 14 | 14 | |
| GSE43470 | MPDZ | 8777 | 5 | 11 | 27 | |
| GSE46452 | MPDZ | 8777 | 2 | 23 | 34 | |
| GSE47630 | MPDZ | 8777 | 4 | 26 | 10 | |
| GSE54993 | MPDZ | 8777 | 6 | 3 | 61 | |
| GSE54994 | MPDZ | 8777 | 10 | 16 | 27 | |
| GSE60625 | MPDZ | 8777 | 0 | 0 | 11 | |
| GSE74703 | MPDZ | 8777 | 5 | 8 | 23 | |
| GSE74704 | MPDZ | 8777 | 0 | 10 | 10 | |
| TCGA | MPDZ | 8777 | 14 | 50 | 32 |
Total number of gains: 50; Total number of losses: 175; Total Number of normals: 263.
Somatic mutations of MPDZ:
Generating mutation plots.
Highly correlated genes for MPDZ:
Showing top 20/937 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MPDZ | TPPP3 | 0.783221 | 3 | 0 | 3 |
| MPDZ | SGCE | 0.779228 | 11 | 0 | 11 |
| MPDZ | AKT3 | 0.771528 | 10 | 0 | 10 |
| MPDZ | GABRA2 | 0.726646 | 3 | 0 | 3 |
| MPDZ | HAND2 | 0.725444 | 4 | 0 | 4 |
| MPDZ | FXYD1 | 0.723655 | 5 | 0 | 4 |
| MPDZ | MYEF2 | 0.723498 | 5 | 0 | 5 |
| MPDZ | RGS7BP | 0.722344 | 3 | 0 | 3 |
| MPDZ | FXYD6 | 0.720401 | 10 | 0 | 9 |
| MPDZ | TIMP3 | 0.717023 | 7 | 0 | 7 |
| MPDZ | TMOD1 | 0.716076 | 6 | 0 | 5 |
| MPDZ | MAP1B | 0.712033 | 12 | 0 | 10 |
| MPDZ | KIAA1107 | 0.711222 | 3 | 0 | 3 |
| MPDZ | KCNT2 | 0.711015 | 6 | 0 | 6 |
| MPDZ | LRCH2 | 0.705718 | 7 | 0 | 6 |
| MPDZ | A2M-AS1 | 0.704765 | 4 | 0 | 4 |
| MPDZ | CCDC136 | 0.704676 | 6 | 0 | 6 |
| MPDZ | FIBIN | 0.70366 | 4 | 0 | 3 |
| MPDZ | ITGA7 | 0.698356 | 8 | 0 | 6 |
| MPDZ | PLCB1 | 0.694649 | 10 | 0 | 9 |
For details and further investigation, click here
