| Full name: tyrosyl-DNA phosphodiesterase 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 6p22.3 | ||
| Entrez ID: 51567 | HGNC ID: HGNC:17768 | Ensembl Gene: ENSG00000111802 | OMIM ID: 605764 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of TDP2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TDP2 | 51567 | 202266_at | 0.3289 | 0.4277 | |
| GSE20347 | TDP2 | 51567 | 202266_at | 0.7180 | 0.0101 | |
| GSE23400 | TDP2 | 51567 | 202266_at | 0.9056 | 0.0000 | |
| GSE26886 | TDP2 | 51567 | 202266_at | 0.5005 | 0.1788 | |
| GSE29001 | TDP2 | 51567 | 202266_at | 0.6139 | 0.0512 | |
| GSE38129 | TDP2 | 51567 | 202266_at | 0.6356 | 0.0012 | |
| GSE45670 | TDP2 | 51567 | 202266_at | 0.3199 | 0.2111 | |
| GSE53622 | TDP2 | 51567 | 107165 | 0.3490 | 0.0000 | |
| GSE53624 | TDP2 | 51567 | 107165 | 0.6640 | 0.0000 | |
| GSE63941 | TDP2 | 51567 | 202266_at | -0.4553 | 0.3284 | |
| GSE77861 | TDP2 | 51567 | 202266_at | 0.8202 | 0.1521 | |
| GSE97050 | TDP2 | 51567 | A_23_P8311 | 0.0827 | 0.7639 | |
| SRP007169 | TDP2 | 51567 | RNAseq | 1.0805 | 0.0044 | |
| SRP008496 | TDP2 | 51567 | RNAseq | 1.0079 | 0.0030 | |
| SRP064894 | TDP2 | 51567 | RNAseq | 0.3956 | 0.0461 | |
| SRP133303 | TDP2 | 51567 | RNAseq | 0.3335 | 0.0011 | |
| SRP159526 | TDP2 | 51567 | RNAseq | 1.0543 | 0.0088 | |
| SRP193095 | TDP2 | 51567 | RNAseq | 0.1670 | 0.5092 | |
| SRP219564 | TDP2 | 51567 | RNAseq | 0.1099 | 0.5811 | |
| TCGA | TDP2 | 51567 | RNAseq | 0.0363 | 0.5981 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by TDP2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TDP2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TDP2 | 51567 | 4 | 2 | 24 | |
| GSE20123 | TDP2 | 51567 | 4 | 2 | 24 | |
| GSE43470 | TDP2 | 51567 | 5 | 0 | 38 | |
| GSE46452 | TDP2 | 51567 | 1 | 9 | 49 | |
| GSE47630 | TDP2 | 51567 | 8 | 5 | 27 | |
| GSE54993 | TDP2 | 51567 | 1 | 1 | 68 | |
| GSE54994 | TDP2 | 51567 | 10 | 4 | 39 | |
| GSE60625 | TDP2 | 51567 | 0 | 1 | 10 | |
| GSE74703 | TDP2 | 51567 | 5 | 0 | 31 | |
| GSE74704 | TDP2 | 51567 | 1 | 1 | 18 | |
| TCGA | TDP2 | 51567 | 17 | 20 | 59 |
Total number of gains: 56; Total number of losses: 45; Total Number of normals: 387.
Somatic mutations of TDP2:
Generating mutation plots.
Highly correlated genes for TDP2:
Showing top 20/1038 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TDP2 | PRR14 | 0.780264 | 3 | 0 | 3 |
| TDP2 | ABHD16A | 0.778993 | 3 | 0 | 3 |
| TDP2 | C1orf50 | 0.760941 | 3 | 0 | 3 |
| TDP2 | SPNS1 | 0.759934 | 3 | 0 | 3 |
| TDP2 | ZFP30 | 0.759093 | 3 | 0 | 3 |
| TDP2 | MGMT | 0.759081 | 3 | 0 | 3 |
| TDP2 | ZNF850 | 0.741597 | 3 | 0 | 3 |
| TDP2 | DZIP3 | 0.741374 | 3 | 0 | 3 |
| TDP2 | TBC1D15 | 0.729751 | 3 | 0 | 3 |
| TDP2 | DYRK2 | 0.725169 | 4 | 0 | 3 |
| TDP2 | SCAMP3 | 0.72267 | 3 | 0 | 3 |
| TDP2 | AIDA | 0.721565 | 3 | 0 | 3 |
| TDP2 | ZNF829 | 0.719125 | 3 | 0 | 3 |
| TDP2 | DHX40 | 0.710672 | 4 | 0 | 3 |
| TDP2 | CMTM6 | 0.707615 | 3 | 0 | 3 |
| TDP2 | ZXDA | 0.70516 | 4 | 0 | 3 |
| TDP2 | ZKSCAN5 | 0.702713 | 4 | 0 | 3 |
| TDP2 | ACOT13 | 0.70234 | 9 | 0 | 8 |
| TDP2 | TUFM | 0.701585 | 3 | 0 | 3 |
| TDP2 | AZIN1 | 0.698966 | 4 | 0 | 3 |
For details and further investigation, click here
