| Full name: sphingolipid transporter 1 (putative) | Alias Symbol: HSpin1|nrs|SPINL|PP2030|SPIN1|LAT|SLC62A1 | ||
| Type: protein-coding gene | Cytoband: 16p11.2 | ||
| Entrez ID: 83985 | HGNC ID: HGNC:30621 | Ensembl Gene: ENSG00000169682 | OMIM ID: 612583 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SPNS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPNS1 | 83985 | 223173_at | 0.6584 | 0.2139 | |
| GSE26886 | SPNS1 | 83985 | 223173_at | 0.2492 | 0.1966 | |
| GSE45670 | SPNS1 | 83985 | 223173_at | 0.5076 | 0.0000 | |
| GSE63941 | SPNS1 | 83985 | 223173_at | -0.3480 | 0.4328 | |
| GSE77861 | SPNS1 | 83985 | 223173_at | 0.3519 | 0.1070 | |
| GSE97050 | SPNS1 | 83985 | A_24_P339153 | 0.7177 | 0.0794 | |
| SRP007169 | SPNS1 | 83985 | RNAseq | 0.4178 | 0.3222 | |
| SRP008496 | SPNS1 | 83985 | RNAseq | 0.0157 | 0.9493 | |
| SRP064894 | SPNS1 | 83985 | RNAseq | 0.7890 | 0.0000 | |
| SRP133303 | SPNS1 | 83985 | RNAseq | 0.6459 | 0.0005 | |
| SRP159526 | SPNS1 | 83985 | RNAseq | 0.8994 | 0.0003 | |
| SRP193095 | SPNS1 | 83985 | RNAseq | 0.6970 | 0.0000 | |
| SRP219564 | SPNS1 | 83985 | RNAseq | 0.6486 | 0.0354 | |
| TCGA | SPNS1 | 83985 | RNAseq | 0.1628 | 0.0013 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SPNS1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of SPNS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPNS1 | 83985 | 5 | 5 | 20 | |
| GSE20123 | SPNS1 | 83985 | 5 | 4 | 21 | |
| GSE43470 | SPNS1 | 83985 | 3 | 3 | 37 | |
| GSE46452 | SPNS1 | 83985 | 38 | 1 | 20 | |
| GSE47630 | SPNS1 | 83985 | 11 | 7 | 22 | |
| GSE54993 | SPNS1 | 83985 | 3 | 5 | 62 | |
| GSE54994 | SPNS1 | 83985 | 5 | 9 | 39 | |
| GSE60625 | SPNS1 | 83985 | 4 | 0 | 7 | |
| GSE74703 | SPNS1 | 83985 | 3 | 2 | 31 | |
| GSE74704 | SPNS1 | 83985 | 3 | 2 | 15 | |
| TCGA | SPNS1 | 83985 | 20 | 12 | 64 |
Total number of gains: 100; Total number of losses: 50; Total Number of normals: 338.
Somatic mutations of SPNS1:
Generating mutation plots.
Highly correlated genes for SPNS1:
Showing top 20/711 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPNS1 | MAGOHB | 0.860055 | 3 | 0 | 3 |
| SPNS1 | UHRF1BP1 | 0.858 | 3 | 0 | 3 |
| SPNS1 | TTC4 | 0.85211 | 3 | 0 | 3 |
| SPNS1 | YARS2 | 0.849755 | 3 | 0 | 3 |
| SPNS1 | TSFM | 0.846337 | 3 | 0 | 3 |
| SPNS1 | TRAF7 | 0.845477 | 4 | 0 | 4 |
| SPNS1 | ABCF2 | 0.845299 | 4 | 0 | 4 |
| SPNS1 | LSM4 | 0.839017 | 3 | 0 | 3 |
| SPNS1 | USP42 | 0.83657 | 3 | 0 | 3 |
| SPNS1 | SFPQ | 0.823096 | 3 | 0 | 3 |
| SPNS1 | MRPL3 | 0.821813 | 3 | 0 | 3 |
| SPNS1 | ATP6V0B | 0.815595 | 3 | 0 | 3 |
| SPNS1 | STAU1 | 0.811442 | 3 | 0 | 3 |
| SPNS1 | ZNHIT1 | 0.810853 | 3 | 0 | 3 |
| SPNS1 | EMG1 | 0.80055 | 3 | 0 | 3 |
| SPNS1 | DDX54 | 0.800002 | 3 | 0 | 3 |
| SPNS1 | MAZ | 0.79651 | 5 | 0 | 5 |
| SPNS1 | FUS | 0.796272 | 4 | 0 | 4 |
| SPNS1 | MRPS15 | 0.795947 | 3 | 0 | 3 |
| SPNS1 | COMMD2 | 0.795316 | 4 | 0 | 4 |
For details and further investigation, click here
