| Full name: dual specificity tyrosine phosphorylation regulated kinase 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12q15 | ||
| Entrez ID: 8445 | HGNC ID: HGNC:3093 | Ensembl Gene: ENSG00000127334 | OMIM ID: 603496 |
| Drug and gene relationship at DGIdb | |||
Expression of DYRK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DYRK2 | 8445 | 202971_s_at | 0.7530 | 0.3582 | |
| GSE20347 | DYRK2 | 8445 | 202971_s_at | -0.1115 | 0.5454 | |
| GSE23400 | DYRK2 | 8445 | 202968_s_at | 0.2217 | 0.0056 | |
| GSE26886 | DYRK2 | 8445 | 202969_at | -0.0705 | 0.8300 | |
| GSE29001 | DYRK2 | 8445 | 202968_s_at | 0.1832 | 0.4637 | |
| GSE38129 | DYRK2 | 8445 | 202971_s_at | 0.2508 | 0.2232 | |
| GSE45670 | DYRK2 | 8445 | 202968_s_at | 0.1239 | 0.4309 | |
| GSE53622 | DYRK2 | 8445 | 37280 | 0.3021 | 0.0005 | |
| GSE53624 | DYRK2 | 8445 | 37280 | 0.2464 | 0.0165 | |
| GSE63941 | DYRK2 | 8445 | 202969_at | -0.6459 | 0.4023 | |
| GSE77861 | DYRK2 | 8445 | 202968_s_at | 0.3605 | 0.0819 | |
| GSE97050 | DYRK2 | 8445 | A_24_P56270 | -0.1395 | 0.5794 | |
| SRP007169 | DYRK2 | 8445 | RNAseq | 0.5969 | 0.0954 | |
| SRP008496 | DYRK2 | 8445 | RNAseq | 0.7828 | 0.0002 | |
| SRP064894 | DYRK2 | 8445 | RNAseq | 0.4457 | 0.0762 | |
| SRP133303 | DYRK2 | 8445 | RNAseq | 0.4996 | 0.0026 | |
| SRP159526 | DYRK2 | 8445 | RNAseq | 0.4499 | 0.0891 | |
| SRP193095 | DYRK2 | 8445 | RNAseq | -0.2434 | 0.2095 | |
| TCGA | DYRK2 | 8445 | RNAseq | -0.0034 | 0.9624 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DYRK2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DYRK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DYRK2 | 8445 | 6 | 0 | 24 | |
| GSE20123 | DYRK2 | 8445 | 6 | 0 | 24 | |
| GSE43470 | DYRK2 | 8445 | 5 | 0 | 38 | |
| GSE46452 | DYRK2 | 8445 | 13 | 0 | 46 | |
| GSE47630 | DYRK2 | 8445 | 10 | 1 | 29 | |
| GSE54993 | DYRK2 | 8445 | 0 | 8 | 62 | |
| GSE54994 | DYRK2 | 8445 | 7 | 1 | 45 | |
| GSE60625 | DYRK2 | 8445 | 0 | 0 | 11 | |
| GSE74703 | DYRK2 | 8445 | 5 | 0 | 31 | |
| GSE74704 | DYRK2 | 8445 | 5 | 0 | 15 | |
| TCGA | DYRK2 | 8445 | 24 | 8 | 64 |
Total number of gains: 81; Total number of losses: 18; Total Number of normals: 389.
Somatic mutations of DYRK2:
Generating mutation plots.
Highly correlated genes for DYRK2:
Showing top 20/596 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DYRK2 | UPF1 | 0.843708 | 3 | 0 | 3 |
| DYRK2 | ZNF322 | 0.842986 | 3 | 0 | 3 |
| DYRK2 | SPATA2 | 0.821076 | 3 | 0 | 3 |
| DYRK2 | SLC25A44 | 0.818829 | 3 | 0 | 3 |
| DYRK2 | TAF1C | 0.812543 | 3 | 0 | 3 |
| DYRK2 | DNAJC11 | 0.810726 | 3 | 0 | 3 |
| DYRK2 | SSBP4 | 0.80173 | 3 | 0 | 3 |
| DYRK2 | NASP | 0.797698 | 3 | 0 | 3 |
| DYRK2 | MAPKAPK2 | 0.797422 | 3 | 0 | 3 |
| DYRK2 | CHERP | 0.793698 | 3 | 0 | 3 |
| DYRK2 | TRIAP1 | 0.791083 | 3 | 0 | 3 |
| DYRK2 | NSUN5 | 0.788086 | 3 | 0 | 3 |
| DYRK2 | C12orf73 | 0.786263 | 3 | 0 | 3 |
| DYRK2 | NUP133 | 0.784965 | 3 | 0 | 3 |
| DYRK2 | PRPF4B | 0.784002 | 3 | 0 | 3 |
| DYRK2 | ZNF765 | 0.781312 | 3 | 0 | 3 |
| DYRK2 | MRPS18B | 0.781197 | 3 | 0 | 3 |
| DYRK2 | WDR81 | 0.778847 | 3 | 0 | 3 |
| DYRK2 | SBNO1 | 0.77863 | 3 | 0 | 3 |
| DYRK2 | SRRT | 0.776344 | 3 | 0 | 3 |
For details and further investigation, click here
