| Full name: O-6-methylguanine-DNA methyltransferase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 10q26.3 | ||
| Entrez ID: 4255 | HGNC ID: HGNC:7059 | Ensembl Gene: ENSG00000170430 | OMIM ID: 156569 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MGMT:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MGMT | 4255 | 204880_at | 0.2723 | 0.2866 | |
| GSE20347 | MGMT | 4255 | 204880_at | -0.0522 | 0.8086 | |
| GSE23400 | MGMT | 4255 | 204880_at | -0.1045 | 0.0850 | |
| GSE26886 | MGMT | 4255 | 204880_at | 0.1091 | 0.8059 | |
| GSE29001 | MGMT | 4255 | 204880_at | -0.0730 | 0.8327 | |
| GSE38129 | MGMT | 4255 | 204880_at | -0.0800 | 0.6034 | |
| GSE45670 | MGMT | 4255 | 204880_at | -0.2885 | 0.1927 | |
| GSE53622 | MGMT | 4255 | 28401 | -0.2770 | 0.0027 | |
| GSE53624 | MGMT | 4255 | 28401 | -0.0939 | 0.2475 | |
| GSE63941 | MGMT | 4255 | 204880_at | -1.7111 | 0.1493 | |
| GSE77861 | MGMT | 4255 | 204880_at | -0.4750 | 0.1182 | |
| GSE97050 | MGMT | 4255 | A_23_P104323 | 0.0347 | 0.9034 | |
| SRP007169 | MGMT | 4255 | RNAseq | -1.2751 | 0.0609 | |
| SRP008496 | MGMT | 4255 | RNAseq | -1.2362 | 0.0255 | |
| SRP064894 | MGMT | 4255 | RNAseq | 0.4539 | 0.2654 | |
| SRP133303 | MGMT | 4255 | RNAseq | -0.3701 | 0.0310 | |
| SRP159526 | MGMT | 4255 | RNAseq | -0.4574 | 0.0421 | |
| SRP193095 | MGMT | 4255 | RNAseq | -0.4258 | 0.0143 | |
| SRP219564 | MGMT | 4255 | RNAseq | -0.0961 | 0.8407 | |
| TCGA | MGMT | 4255 | RNAseq | -0.1059 | 0.4196 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by MGMT expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MGMT:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MGMT | 4255 | 2 | 8 | 20 | |
| GSE20123 | MGMT | 4255 | 2 | 8 | 20 | |
| GSE43470 | MGMT | 4255 | 0 | 11 | 32 | |
| GSE46452 | MGMT | 4255 | 0 | 11 | 48 | |
| GSE47630 | MGMT | 4255 | 4 | 13 | 23 | |
| GSE54993 | MGMT | 4255 | 8 | 1 | 61 | |
| GSE54994 | MGMT | 4255 | 1 | 9 | 43 | |
| GSE60625 | MGMT | 4255 | 0 | 0 | 11 | |
| GSE74703 | MGMT | 4255 | 0 | 7 | 29 | |
| GSE74704 | MGMT | 4255 | 2 | 3 | 15 | |
| TCGA | MGMT | 4255 | 8 | 28 | 60 |
Total number of gains: 27; Total number of losses: 99; Total Number of normals: 362.
Somatic mutations of MGMT:
Generating mutation plots.
Highly correlated genes for MGMT:
Showing top 20/206 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MGMT | CHUK | 0.769827 | 3 | 0 | 3 |
| MGMT | ZKSCAN4 | 0.767735 | 3 | 0 | 3 |
| MGMT | COMMD7 | 0.76595 | 3 | 0 | 3 |
| MGMT | KLHDC3 | 0.765079 | 3 | 0 | 3 |
| MGMT | TDP2 | 0.759081 | 3 | 0 | 3 |
| MGMT | VRK3 | 0.75634 | 3 | 0 | 3 |
| MGMT | NPRL2 | 0.75554 | 3 | 0 | 3 |
| MGMT | PALB2 | 0.741319 | 3 | 0 | 3 |
| MGMT | NDUFB6 | 0.734315 | 3 | 0 | 3 |
| MGMT | POLR2B | 0.733665 | 3 | 0 | 3 |
| MGMT | ATG4C | 0.718519 | 3 | 0 | 3 |
| MGMT | VPS41 | 0.716219 | 3 | 0 | 3 |
| MGMT | CLP1 | 0.713839 | 4 | 0 | 4 |
| MGMT | RSBN1L | 0.713515 | 3 | 0 | 3 |
| MGMT | STARD7 | 0.707905 | 3 | 0 | 3 |
| MGMT | RIOK2 | 0.707808 | 3 | 0 | 3 |
| MGMT | PTPN1 | 0.697074 | 3 | 0 | 3 |
| MGMT | STAG1 | 0.690929 | 3 | 0 | 3 |
| MGMT | NOTCH2 | 0.687105 | 3 | 0 | 3 |
| MGMT | PRADC1 | 0.686138 | 4 | 0 | 3 |
For details and further investigation, click here
