| Full name: tetratricopeptide repeat domain 1 | Alias Symbol: TPR1 | ||
| Type: protein-coding gene | Cytoband: 5q33.3 | ||
| Entrez ID: 7265 | HGNC ID: HGNC:12391 | Ensembl Gene: ENSG00000113312 | OMIM ID: 601963 |
| Drug and gene relationship at DGIdb | |||
Expression of TTC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TTC1 | 7265 | 201434_at | -0.2387 | 0.5218 | |
| GSE20347 | TTC1 | 7265 | 201434_at | -0.2734 | 0.0355 | |
| GSE23400 | TTC1 | 7265 | 201434_at | -0.1913 | 0.0000 | |
| GSE26886 | TTC1 | 7265 | 201434_at | -0.5089 | 0.0026 | |
| GSE29001 | TTC1 | 7265 | 201434_at | -0.1744 | 0.4416 | |
| GSE38129 | TTC1 | 7265 | 201434_at | -0.2715 | 0.0168 | |
| GSE45670 | TTC1 | 7265 | 201434_at | -0.0373 | 0.8530 | |
| GSE53622 | TTC1 | 7265 | 142901 | -0.3845 | 0.0000 | |
| GSE53624 | TTC1 | 7265 | 142901 | -0.2941 | 0.0002 | |
| GSE63941 | TTC1 | 7265 | 201434_at | 0.0120 | 0.9776 | |
| GSE77861 | TTC1 | 7265 | 201434_at | -0.1742 | 0.4730 | |
| GSE97050 | TTC1 | 7265 | A_23_P19164 | -0.3366 | 0.3376 | |
| SRP007169 | TTC1 | 7265 | RNAseq | 0.6604 | 0.3121 | |
| SRP064894 | TTC1 | 7265 | RNAseq | -0.0381 | 0.8367 | |
| SRP133303 | TTC1 | 7265 | RNAseq | -0.0564 | 0.7367 | |
| SRP159526 | TTC1 | 7265 | RNAseq | -0.2938 | 0.3407 | |
| SRP193095 | TTC1 | 7265 | RNAseq | -0.4416 | 0.0000 | |
| SRP219564 | TTC1 | 7265 | RNAseq | -0.3662 | 0.2433 | |
| TCGA | TTC1 | 7265 | RNAseq | -0.0702 | 0.1891 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TTC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TTC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TTC1 | 7265 | 0 | 11 | 19 | |
| GSE20123 | TTC1 | 7265 | 0 | 11 | 19 | |
| GSE43470 | TTC1 | 7265 | 2 | 10 | 31 | |
| GSE46452 | TTC1 | 7265 | 0 | 27 | 32 | |
| GSE47630 | TTC1 | 7265 | 0 | 20 | 20 | |
| GSE54993 | TTC1 | 7265 | 9 | 2 | 59 | |
| GSE54994 | TTC1 | 7265 | 1 | 16 | 36 | |
| GSE60625 | TTC1 | 7265 | 0 | 0 | 11 | |
| GSE74703 | TTC1 | 7265 | 2 | 8 | 26 | |
| GSE74704 | TTC1 | 7265 | 0 | 6 | 14 | |
| TCGA | TTC1 | 7265 | 4 | 37 | 55 |
Total number of gains: 18; Total number of losses: 148; Total Number of normals: 322.
Somatic mutations of TTC1:
Generating mutation plots.
Highly correlated genes for TTC1:
Showing top 20/184 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TTC1 | CAMLG | 0.696162 | 4 | 0 | 4 |
| TTC1 | AXL | 0.683352 | 3 | 0 | 3 |
| TTC1 | EGFLAM-AS2 | 0.667366 | 3 | 0 | 3 |
| TTC1 | MARCO | 0.645601 | 3 | 0 | 3 |
| TTC1 | ZNF185 | 0.642835 | 3 | 0 | 3 |
| TTC1 | GNG12 | 0.64222 | 4 | 0 | 3 |
| TTC1 | ETFB | 0.637928 | 4 | 0 | 3 |
| TTC1 | CYLD | 0.63511 | 4 | 0 | 4 |
| TTC1 | KLHL20 | 0.631543 | 3 | 0 | 3 |
| TTC1 | FAM162B | 0.621769 | 3 | 0 | 3 |
| TTC1 | SLU7 | 0.617682 | 7 | 0 | 6 |
| TTC1 | UGP2 | 0.617275 | 5 | 0 | 5 |
| TTC1 | MOCS2 | 0.616559 | 8 | 0 | 6 |
| TTC1 | MOB2 | 0.615082 | 5 | 0 | 4 |
| TTC1 | ATP6V0D1 | 0.613544 | 7 | 0 | 6 |
| TTC1 | SCAPER | 0.613062 | 4 | 0 | 3 |
| TTC1 | DCTN4 | 0.610051 | 9 | 0 | 6 |
| TTC1 | TCAIM | 0.610035 | 3 | 0 | 3 |
| TTC1 | MRPL22 | 0.608132 | 11 | 0 | 7 |
| TTC1 | NUDT12 | 0.607689 | 4 | 0 | 4 |
For details and further investigation, click here
