| Full name: dynactin subunit 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5q33.1 | ||
| Entrez ID: 51164 | HGNC ID: HGNC:15518 | Ensembl Gene: ENSG00000132912 | OMIM ID: 614758 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of DCTN4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DCTN4 | 51164 | 222488_s_at | -0.2031 | 0.5069 | |
| GSE20347 | DCTN4 | 51164 | 218013_x_at | -0.1504 | 0.3092 | |
| GSE23400 | DCTN4 | 51164 | 218013_x_at | -0.0721 | 0.2537 | |
| GSE26886 | DCTN4 | 51164 | 222488_s_at | -0.2319 | 0.3890 | |
| GSE29001 | DCTN4 | 51164 | 218013_x_at | -0.2784 | 0.2233 | |
| GSE38129 | DCTN4 | 51164 | 218013_x_at | 0.0077 | 0.9646 | |
| GSE45670 | DCTN4 | 51164 | 222488_s_at | -0.1039 | 0.5296 | |
| GSE53622 | DCTN4 | 51164 | 30891 | -0.3296 | 0.0000 | |
| GSE53624 | DCTN4 | 51164 | 30891 | -0.3208 | 0.0000 | |
| GSE63941 | DCTN4 | 51164 | 222488_s_at | -0.6425 | 0.1429 | |
| GSE77861 | DCTN4 | 51164 | 222488_s_at | -0.3614 | 0.2946 | |
| GSE97050 | DCTN4 | 51164 | A_23_P251945 | -0.3031 | 0.2280 | |
| SRP007169 | DCTN4 | 51164 | RNAseq | -0.7923 | 0.0299 | |
| SRP008496 | DCTN4 | 51164 | RNAseq | -0.7432 | 0.0002 | |
| SRP064894 | DCTN4 | 51164 | RNAseq | -0.1583 | 0.1917 | |
| SRP133303 | DCTN4 | 51164 | RNAseq | -0.0524 | 0.7133 | |
| SRP159526 | DCTN4 | 51164 | RNAseq | -0.2792 | 0.5125 | |
| SRP193095 | DCTN4 | 51164 | RNAseq | -0.3394 | 0.0014 | |
| SRP219564 | DCTN4 | 51164 | RNAseq | -0.0703 | 0.8407 | |
| TCGA | DCTN4 | 51164 | RNAseq | -0.1072 | 0.0142 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DCTN4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DCTN4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DCTN4 | 51164 | 1 | 12 | 17 | |
| GSE20123 | DCTN4 | 51164 | 1 | 12 | 17 | |
| GSE43470 | DCTN4 | 51164 | 1 | 10 | 32 | |
| GSE46452 | DCTN4 | 51164 | 0 | 27 | 32 | |
| GSE47630 | DCTN4 | 51164 | 0 | 20 | 20 | |
| GSE54993 | DCTN4 | 51164 | 9 | 1 | 60 | |
| GSE54994 | DCTN4 | 51164 | 2 | 15 | 36 | |
| GSE60625 | DCTN4 | 51164 | 0 | 0 | 11 | |
| GSE74703 | DCTN4 | 51164 | 1 | 7 | 28 | |
| GSE74704 | DCTN4 | 51164 | 1 | 7 | 12 | |
| TCGA | DCTN4 | 51164 | 5 | 37 | 54 |
Total number of gains: 21; Total number of losses: 148; Total Number of normals: 319.
Somatic mutations of DCTN4:
Generating mutation plots.
Highly correlated genes for DCTN4:
Showing top 20/534 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DCTN4 | SNRNP27 | 0.781584 | 4 | 0 | 4 |
| DCTN4 | ZZZ3 | 0.760915 | 3 | 0 | 3 |
| DCTN4 | WDR20 | 0.75614 | 3 | 0 | 3 |
| DCTN4 | DHRS7 | 0.749806 | 4 | 0 | 3 |
| DCTN4 | EXOC8 | 0.737035 | 3 | 0 | 3 |
| DCTN4 | SNX13 | 0.732913 | 4 | 0 | 4 |
| DCTN4 | PAAF1 | 0.726878 | 3 | 0 | 3 |
| DCTN4 | CAMK2D | 0.725431 | 3 | 0 | 3 |
| DCTN4 | CRYBG3 | 0.723138 | 3 | 0 | 3 |
| DCTN4 | PPP4R1 | 0.716152 | 4 | 0 | 3 |
| DCTN4 | PITPNM3 | 0.714659 | 3 | 0 | 3 |
| DCTN4 | TNRC6A | 0.712031 | 3 | 0 | 3 |
| DCTN4 | PREPL | 0.709437 | 3 | 0 | 3 |
| DCTN4 | MOB3B | 0.708376 | 3 | 0 | 3 |
| DCTN4 | UBE2A | 0.708177 | 3 | 0 | 3 |
| DCTN4 | DUSP19 | 0.706968 | 3 | 0 | 3 |
| DCTN4 | HINT3 | 0.702133 | 4 | 0 | 3 |
| DCTN4 | LYSMD2 | 0.700199 | 3 | 0 | 3 |
| DCTN4 | DENND1B | 0.694294 | 5 | 0 | 5 |
| DCTN4 | CLK1 | 0.6942 | 3 | 0 | 3 |
For details and further investigation, click here
