GNG12

 

Full name: G protein subunit gamma 12 Alias Symbol: 
Type: protein-coding gene Cytoband: 1p31.3
Entrez ID: 55970 HGNC ID: HGNC:19663 Ensembl Gene: ENSG00000172380 OMIM ID: 615405
Drug and gene relationship at DGIdb

 

GNG12 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04014Ras signaling pathway
hsa04062Chemokine signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04713Circadian entrainment
hsa04723Retrograde endocannabinoid signaling
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04726Serotonergic synapse
hsa04727GABAergic synapse
hsa04728Dopaminergic synapse
hsa04810Regulation of actin cytoskeleton
hsa05032Morphine addiction
hsa05034Alcoholism

 

Expression of GNG12:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GNG12 55970 212294_at -0.2294 0.6052
GSE20347 GNG12 55970 212294_at -0.6035 0.0003
GSE23400 GNG12 55970 212294_at -0.3940 0.0000
GSE26886 GNG12 55970 212294_at -1.2215 0.0000
GSE29001 GNG12 55970 212294_at -0.6351 0.0076
GSE38129 GNG12 55970 212294_at -0.5131 0.0000
GSE45670 GNG12 55970 212294_at -0.3390 0.0174
GSE53622 GNG12 55970 40695 -0.9947 0.0000
GSE53624 GNG12 55970 40695 -0.9575 0.0000
GSE63941 GNG12 55970 212294_at -1.5689 0.0072
GSE77861 GNG12 55970 212294_at -0.3438 0.0787
GSE97050 GNG12 55970 A_33_P3399318 -0.4579 0.1618
SRP007169 GNG12 55970 RNAseq -2.1998 0.0000
SRP008496 GNG12 55970 RNAseq -1.8567 0.0000
SRP064894 GNG12 55970 RNAseq -0.8693 0.0000
SRP133303 GNG12 55970 RNAseq -0.3425 0.1494
SRP159526 GNG12 55970 RNAseq -1.6145 0.0000
SRP193095 GNG12 55970 RNAseq -1.0551 0.0000
SRP219564 GNG12 55970 RNAseq -0.7367 0.0214
TCGA GNG12 55970 RNAseq -0.0703 0.1411

Upregulated datasets: 0; Downregulated datasets: 6.  

 

Survival by GNG12 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GNG12:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GNG12 55970 1 6 23
GSE20123 GNG12 55970 1 5 24
GSE43470 GNG12 55970 5 2 36
GSE46452 GNG12 55970 0 1 58
GSE47630 GNG12 55970 7 6 27
GSE54993 GNG12 55970 0 0 70
GSE54994 GNG12 55970 6 4 43
GSE60625 GNG12 55970 0 0 11
GSE74703 GNG12 55970 4 2 30
GSE74704 GNG12 55970 1 2 17
TCGA GNG12 55970 8 22 66

Total number of gains: 33; Total number of losses: 50; Total Number of normals: 405.  

 

Somatic mutations of GNG12:

 

Generating mutation plots.

 

Highly correlated genes for GNG12:

 

Showing top 20/1240 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GNG12MTIF30.785295303
GNG12RARS20.77394303
GNG12PALMD0.77321910010
GNG12YPEL30.772119303
GNG12PIGV0.768531303
GNG12ZNF4070.767704303
GNG12SEMA6A0.76416303
GNG12HDHD20.762508303
GNG12EVC20.761399303
GNG12EIF1AY0.757439303
GNG12FNIP10.751973403
GNG12CLEC3B0.747289303
GNG12RAB1A0.731495404
GNG12CSNK1G30.730473303
GNG12MMGT10.728493303
GNG12MLKL0.727003303
GNG12FYTTD10.72421403
GNG12ARL150.723632303
GNG12NFIA0.72024605
GNG12CTTNBP2NL0.719214808

For details and further investigation, click here