| Full name: AXL receptor tyrosine kinase | Alias Symbol: UFO|JTK11|Tyro7|ARK | ||
| Type: protein-coding gene | Cytoband: 19q13.2 | ||
| Entrez ID: 558 | HGNC ID: HGNC:905 | Ensembl Gene: ENSG00000167601 | OMIM ID: 109135 |
| Drug and gene relationship at DGIdb | |||
Expression of AXL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AXL | 558 | 202686_s_at | -0.6052 | 0.4985 | |
| GSE20347 | AXL | 558 | 202686_s_at | -0.1092 | 0.5756 | |
| GSE23400 | AXL | 558 | 202686_s_at | -0.0978 | 0.5582 | |
| GSE26886 | AXL | 558 | 202686_s_at | -0.7002 | 0.2016 | |
| GSE29001 | AXL | 558 | 202686_s_at | -0.0724 | 0.9131 | |
| GSE38129 | AXL | 558 | 202686_s_at | -0.3579 | 0.3702 | |
| GSE45670 | AXL | 558 | 202686_s_at | -1.0383 | 0.0016 | |
| GSE53622 | AXL | 558 | 50787 | 0.2136 | 0.1391 | |
| GSE53624 | AXL | 558 | 50787 | 0.1669 | 0.4102 | |
| GSE63941 | AXL | 558 | 202686_s_at | -2.8179 | 0.0702 | |
| GSE77861 | AXL | 558 | 202685_s_at | -0.0290 | 0.8060 | |
| GSE97050 | AXL | 558 | A_23_P208389 | -0.0742 | 0.7449 | |
| SRP007169 | AXL | 558 | RNAseq | 1.1434 | 0.0201 | |
| SRP008496 | AXL | 558 | RNAseq | 1.0328 | 0.0003 | |
| SRP064894 | AXL | 558 | RNAseq | 0.4162 | 0.0669 | |
| SRP133303 | AXL | 558 | RNAseq | 0.2734 | 0.3160 | |
| SRP159526 | AXL | 558 | RNAseq | -0.0103 | 0.9779 | |
| SRP193095 | AXL | 558 | RNAseq | 0.5389 | 0.0044 | |
| SRP219564 | AXL | 558 | RNAseq | 0.1579 | 0.7728 | |
| TCGA | AXL | 558 | RNAseq | -0.2164 | 0.0321 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by AXL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AXL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AXL | 558 | 4 | 4 | 22 | |
| GSE20123 | AXL | 558 | 4 | 3 | 23 | |
| GSE43470 | AXL | 558 | 3 | 11 | 29 | |
| GSE46452 | AXL | 558 | 48 | 1 | 10 | |
| GSE47630 | AXL | 558 | 9 | 5 | 26 | |
| GSE54993 | AXL | 558 | 17 | 4 | 49 | |
| GSE54994 | AXL | 558 | 6 | 11 | 36 | |
| GSE60625 | AXL | 558 | 9 | 0 | 2 | |
| GSE74703 | AXL | 558 | 3 | 7 | 26 | |
| GSE74704 | AXL | 558 | 4 | 1 | 15 | |
| TCGA | AXL | 558 | 14 | 16 | 66 |
Total number of gains: 121; Total number of losses: 63; Total Number of normals: 304.
Somatic mutations of AXL:
Generating mutation plots.
Highly correlated genes for AXL:
Showing top 20/1117 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AXL | CLMP | 0.772797 | 6 | 0 | 6 |
| AXL | FIBIN | 0.771992 | 4 | 0 | 3 |
| AXL | CYTH3 | 0.750569 | 4 | 0 | 4 |
| AXL | CNRIP1 | 0.749737 | 7 | 0 | 7 |
| AXL | TYW3 | 0.748392 | 3 | 0 | 3 |
| AXL | MYADM | 0.747187 | 5 | 0 | 5 |
| AXL | SGCE | 0.742292 | 9 | 0 | 9 |
| AXL | BICC1 | 0.742087 | 9 | 0 | 8 |
| AXL | DAPK1 | 0.740332 | 6 | 0 | 5 |
| AXL | CCDC80 | 0.739196 | 6 | 0 | 6 |
| AXL | OLFML1 | 0.738781 | 9 | 0 | 8 |
| AXL | KIAA1328 | 0.735028 | 3 | 0 | 3 |
| AXL | SAMM50 | 0.734909 | 3 | 0 | 3 |
| AXL | FAM122C | 0.734866 | 3 | 0 | 3 |
| AXL | CDIPT | 0.734762 | 3 | 0 | 3 |
| AXL | CACNA2D4 | 0.734656 | 3 | 0 | 3 |
| AXL | TMEM204 | 0.731218 | 7 | 0 | 6 |
| AXL | CDC40 | 0.72894 | 3 | 0 | 3 |
| AXL | ANXA6 | 0.728553 | 11 | 0 | 9 |
| AXL | ZCCHC24 | 0.728148 | 9 | 0 | 9 |
For details and further investigation, click here
