| Full name: mitochondrial ribosomal protein L22 | Alias Symbol: MRP-L25|RPML25|HSPC158 | ||
| Type: protein-coding gene | Cytoband: 5q33.2 | ||
| Entrez ID: 29093 | HGNC ID: HGNC:14480 | Ensembl Gene: ENSG00000082515 | OMIM ID: 611835 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MRPL22:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MRPL22 | 29093 | 218339_at | -0.2278 | 0.6746 | |
| GSE20347 | MRPL22 | 29093 | 218339_at | -0.4335 | 0.0340 | |
| GSE23400 | MRPL22 | 29093 | 218339_at | -0.1649 | 0.0354 | |
| GSE26886 | MRPL22 | 29093 | 218339_at | 0.0869 | 0.6380 | |
| GSE29001 | MRPL22 | 29093 | 218339_at | -0.3746 | 0.2254 | |
| GSE38129 | MRPL22 | 29093 | 218339_at | -0.2721 | 0.0520 | |
| GSE45670 | MRPL22 | 29093 | 218339_at | -0.0584 | 0.7182 | |
| GSE53622 | MRPL22 | 29093 | 24611 | -0.0952 | 0.1603 | |
| GSE53624 | MRPL22 | 29093 | 24611 | -0.0215 | 0.7409 | |
| GSE63941 | MRPL22 | 29093 | 218339_at | 0.8572 | 0.0024 | |
| GSE77861 | MRPL22 | 29093 | 218339_at | -0.5198 | 0.0044 | |
| GSE97050 | MRPL22 | 29093 | A_23_P122233 | -0.0033 | 0.9890 | |
| SRP007169 | MRPL22 | 29093 | RNAseq | -0.7043 | 0.0317 | |
| SRP008496 | MRPL22 | 29093 | RNAseq | -0.7794 | 0.0006 | |
| SRP064894 | MRPL22 | 29093 | RNAseq | 0.0725 | 0.7465 | |
| SRP133303 | MRPL22 | 29093 | RNAseq | 0.0950 | 0.5132 | |
| SRP159526 | MRPL22 | 29093 | RNAseq | -0.0530 | 0.8854 | |
| SRP193095 | MRPL22 | 29093 | RNAseq | -0.4491 | 0.0000 | |
| SRP219564 | MRPL22 | 29093 | RNAseq | -0.0415 | 0.9128 | |
| TCGA | MRPL22 | 29093 | RNAseq | 0.0335 | 0.5904 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MRPL22 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MRPL22:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MRPL22 | 29093 | 0 | 12 | 18 | |
| GSE20123 | MRPL22 | 29093 | 0 | 12 | 18 | |
| GSE43470 | MRPL22 | 29093 | 2 | 10 | 31 | |
| GSE46452 | MRPL22 | 29093 | 0 | 27 | 32 | |
| GSE47630 | MRPL22 | 29093 | 0 | 20 | 20 | |
| GSE54993 | MRPL22 | 29093 | 9 | 1 | 60 | |
| GSE54994 | MRPL22 | 29093 | 1 | 16 | 36 | |
| GSE60625 | MRPL22 | 29093 | 0 | 0 | 11 | |
| GSE74703 | MRPL22 | 29093 | 2 | 8 | 26 | |
| GSE74704 | MRPL22 | 29093 | 0 | 7 | 13 | |
| TCGA | MRPL22 | 29093 | 4 | 37 | 55 |
Total number of gains: 18; Total number of losses: 150; Total Number of normals: 320.
Somatic mutations of MRPL22:
Generating mutation plots.
Highly correlated genes for MRPL22:
Showing top 20/201 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MRPL22 | DTWD2 | 0.713141 | 3 | 0 | 3 |
| MRPL22 | TF | 0.691515 | 3 | 0 | 3 |
| MRPL22 | RDH12 | 0.683002 | 3 | 0 | 3 |
| MRPL22 | EIF3F | 0.675419 | 3 | 0 | 3 |
| MRPL22 | PTK6 | 0.662441 | 3 | 0 | 3 |
| MRPL22 | C19orf33 | 0.658589 | 3 | 0 | 3 |
| MRPL22 | RBM47 | 0.650119 | 3 | 0 | 3 |
| MRPL22 | HADHB | 0.645626 | 4 | 0 | 4 |
| MRPL22 | PRSS27 | 0.643389 | 3 | 0 | 3 |
| MRPL22 | DNASE1L3 | 0.640961 | 4 | 0 | 4 |
| MRPL22 | CNOT1 | 0.636896 | 4 | 0 | 3 |
| MRPL22 | TPD52L1 | 0.629701 | 4 | 0 | 3 |
| MRPL22 | CHMP2A | 0.628988 | 5 | 0 | 4 |
| MRPL22 | NHP2 | 0.625902 | 7 | 0 | 6 |
| MRPL22 | EREG | 0.624647 | 4 | 0 | 3 |
| MRPL22 | UEVLD | 0.623151 | 5 | 0 | 4 |
| MRPL22 | RAD50 | 0.622657 | 4 | 0 | 3 |
| MRPL22 | RPL6 | 0.619596 | 6 | 0 | 5 |
| MRPL22 | PRMT5 | 0.6151 | 4 | 0 | 4 |
| MRPL22 | OXSM | 0.61342 | 4 | 0 | 3 |
For details and further investigation, click here
