| Full name: CYLD lysine 63 deubiquitinase | Alias Symbol: KIAA0849|USPL2 | ||
| Type: protein-coding gene | Cytoband: 16q12.1 | ||
| Entrez ID: 1540 | HGNC ID: HGNC:2584 | Ensembl Gene: ENSG00000083799 | OMIM ID: 605018 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
CYLD involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04380 | Osteoclast differentiation | |
| hsa04622 | RIG-I-like receptor signaling pathway |
Expression of CYLD:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CYLD | 1540 | 221903_s_at | 0.1012 | 0.8796 | |
| GSE20347 | CYLD | 1540 | 221903_s_at | -0.2806 | 0.2015 | |
| GSE23400 | CYLD | 1540 | 221903_s_at | -0.0599 | 0.6161 | |
| GSE26886 | CYLD | 1540 | 221903_s_at | -1.0699 | 0.0005 | |
| GSE29001 | CYLD | 1540 | 221903_s_at | -0.0485 | 0.7977 | |
| GSE38129 | CYLD | 1540 | 221903_s_at | -0.1172 | 0.4707 | |
| GSE45670 | CYLD | 1540 | 221903_s_at | 0.2081 | 0.1784 | |
| GSE53622 | CYLD | 1540 | 32544 | -0.9181 | 0.0000 | |
| GSE53624 | CYLD | 1540 | 32544 | -0.9354 | 0.0000 | |
| GSE63941 | CYLD | 1540 | 221903_s_at | -1.4290 | 0.0210 | |
| GSE77861 | CYLD | 1540 | 221903_s_at | -0.2460 | 0.4348 | |
| GSE97050 | CYLD | 1540 | A_33_P3251771 | -0.1570 | 0.4802 | |
| SRP007169 | CYLD | 1540 | RNAseq | -0.1168 | 0.8192 | |
| SRP008496 | CYLD | 1540 | RNAseq | 0.0992 | 0.7578 | |
| SRP064894 | CYLD | 1540 | RNAseq | -0.6311 | 0.0009 | |
| SRP133303 | CYLD | 1540 | RNAseq | -0.2059 | 0.1990 | |
| SRP159526 | CYLD | 1540 | RNAseq | -0.4469 | 0.2601 | |
| SRP193095 | CYLD | 1540 | RNAseq | -0.2589 | 0.0155 | |
| SRP219564 | CYLD | 1540 | RNAseq | -0.2992 | 0.5575 | |
| TCGA | CYLD | 1540 | RNAseq | -0.0573 | 0.2584 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by CYLD expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CYLD:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CYLD | 1540 | 3 | 1 | 26 | |
| GSE20123 | CYLD | 1540 | 3 | 1 | 26 | |
| GSE43470 | CYLD | 1540 | 2 | 7 | 34 | |
| GSE46452 | CYLD | 1540 | 38 | 1 | 20 | |
| GSE47630 | CYLD | 1540 | 11 | 7 | 22 | |
| GSE54993 | CYLD | 1540 | 2 | 5 | 63 | |
| GSE54994 | CYLD | 1540 | 6 | 10 | 37 | |
| GSE60625 | CYLD | 1540 | 4 | 0 | 7 | |
| GSE74703 | CYLD | 1540 | 2 | 4 | 30 | |
| GSE74704 | CYLD | 1540 | 3 | 1 | 16 | |
| TCGA | CYLD | 1540 | 25 | 12 | 59 |
Total number of gains: 99; Total number of losses: 49; Total Number of normals: 340.
Somatic mutations of CYLD:
Generating mutation plots.
Highly correlated genes for CYLD:
Showing top 20/648 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CYLD | PITPNA | 0.777621 | 3 | 0 | 3 |
| CYLD | MLKL | 0.765845 | 3 | 0 | 3 |
| CYLD | RSPRY1 | 0.754684 | 3 | 0 | 3 |
| CYLD | DEF8 | 0.740223 | 3 | 0 | 3 |
| CYLD | COMMD9 | 0.738649 | 3 | 0 | 3 |
| CYLD | ARSK | 0.734501 | 3 | 0 | 3 |
| CYLD | TMEM186 | 0.731635 | 3 | 0 | 3 |
| CYLD | MRPS22 | 0.73028 | 3 | 0 | 3 |
| CYLD | SNX4 | 0.72994 | 3 | 0 | 3 |
| CYLD | ETS1 | 0.725563 | 3 | 0 | 3 |
| CYLD | FYTTD1 | 0.724001 | 4 | 0 | 4 |
| CYLD | TPCN1 | 0.722512 | 4 | 0 | 4 |
| CYLD | MAP4K5 | 0.722362 | 3 | 0 | 3 |
| CYLD | PDZD11 | 0.722258 | 4 | 0 | 3 |
| CYLD | SYTL4 | 0.72149 | 3 | 0 | 3 |
| CYLD | KDM3B | 0.720821 | 4 | 0 | 4 |
| CYLD | HVCN1 | 0.719389 | 3 | 0 | 3 |
| CYLD | NLRP3 | 0.713169 | 4 | 0 | 4 |
| CYLD | MAT2B | 0.711057 | 3 | 0 | 3 |
| CYLD | FRMD6 | 0.710364 | 3 | 0 | 3 |
For details and further investigation, click here
