| Full name: tetratricopeptide repeat domain 21B | Alias Symbol: FLJ11457|JBTS11|NPHP12|IFT139B|THM1 | ||
| Type: protein-coding gene | Cytoband: 2q24.3 | ||
| Entrez ID: 79809 | HGNC ID: HGNC:25660 | Ensembl Gene: ENSG00000123607 | OMIM ID: 612014 |
| Drug and gene relationship at DGIdb | |||
Expression of TTC21B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | TTC21B | 79809 | 55665 | 0.0140 | 0.8927 | |
| GSE53624 | TTC21B | 79809 | 55665 | 0.2440 | 0.0225 | |
| GSE97050 | TTC21B | 79809 | A_24_P111511 | -0.1546 | 0.4937 | |
| SRP007169 | TTC21B | 79809 | RNAseq | 0.6665 | 0.1390 | |
| SRP008496 | TTC21B | 79809 | RNAseq | 0.6561 | 0.0251 | |
| SRP064894 | TTC21B | 79809 | RNAseq | -0.0475 | 0.8258 | |
| SRP133303 | TTC21B | 79809 | RNAseq | -0.0174 | 0.8960 | |
| SRP159526 | TTC21B | 79809 | RNAseq | 0.2789 | 0.2980 | |
| SRP193095 | TTC21B | 79809 | RNAseq | -0.0018 | 0.9877 | |
| SRP219564 | TTC21B | 79809 | RNAseq | -0.3138 | 0.3686 | |
| TCGA | TTC21B | 79809 | RNAseq | -0.0842 | 0.2472 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TTC21B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TTC21B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TTC21B | 79809 | 5 | 1 | 24 | |
| GSE20123 | TTC21B | 79809 | 4 | 1 | 25 | |
| GSE43470 | TTC21B | 79809 | 5 | 1 | 37 | |
| GSE46452 | TTC21B | 79809 | 1 | 4 | 54 | |
| GSE47630 | TTC21B | 79809 | 5 | 3 | 32 | |
| GSE54993 | TTC21B | 79809 | 0 | 5 | 65 | |
| GSE54994 | TTC21B | 79809 | 11 | 2 | 40 | |
| GSE60625 | TTC21B | 79809 | 0 | 3 | 8 | |
| GSE74703 | TTC21B | 79809 | 4 | 1 | 31 | |
| GSE74704 | TTC21B | 79809 | 2 | 0 | 18 | |
| TCGA | TTC21B | 79809 | 23 | 10 | 63 |
Total number of gains: 60; Total number of losses: 31; Total Number of normals: 397.
Somatic mutations of TTC21B:
Generating mutation plots.
Highly correlated genes for TTC21B:
Showing top 20/21 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TTC21B | PHOSPHO2 | 0.795391 | 3 | 0 | 3 |
| TTC21B | CASP8AP2 | 0.751153 | 3 | 0 | 3 |
| TTC21B | EFCAB7 | 0.733066 | 3 | 0 | 3 |
| TTC21B | CEP70 | 0.71418 | 3 | 0 | 3 |
| TTC21B | ZBTB10 | 0.702594 | 3 | 0 | 3 |
| TTC21B | MATR3 | 0.699722 | 3 | 0 | 3 |
| TTC21B | ZNF566 | 0.697756 | 3 | 0 | 3 |
| TTC21B | ORC4 | 0.693839 | 3 | 0 | 3 |
| TTC21B | OSGEPL1 | 0.688706 | 3 | 0 | 3 |
| TTC21B | PHF3 | 0.679185 | 3 | 0 | 3 |
| TTC21B | CCDC121 | 0.679162 | 3 | 0 | 3 |
| TTC21B | ZNF280D | 0.678629 | 3 | 0 | 3 |
| TTC21B | ZDHHC17 | 0.673954 | 3 | 0 | 3 |
| TTC21B | SOCS5 | 0.673489 | 3 | 0 | 3 |
| TTC21B | ZNF17 | 0.66432 | 3 | 0 | 3 |
| TTC21B | DZIP1 | 0.656922 | 3 | 0 | 3 |
| TTC21B | ALG10B | 0.656589 | 3 | 0 | 3 |
| TTC21B | CENPV | 0.6491 | 3 | 0 | 3 |
| TTC21B | CHD6 | 0.646867 | 3 | 0 | 3 |
| TTC21B | ZNF45 | 0.618362 | 3 | 0 | 3 |
For details and further investigation, click here
