| Full name: caspase 8 associated protein 2 | Alias Symbol: FLASH|CED-4|RIP25|FLJ11208|KIAA1315 | ||
| Type: protein-coding gene | Cytoband: 6q15 | ||
| Entrez ID: 9994 | HGNC ID: HGNC:1510 | Ensembl Gene: ENSG00000118412 | OMIM ID: 606880 |
| Drug and gene relationship at DGIdb | |||
Expression of CASP8AP2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CASP8AP2 | 9994 | 222201_s_at | 0.1161 | 0.8164 | |
| GSE20347 | CASP8AP2 | 9994 | 222201_s_at | 0.5584 | 0.0018 | |
| GSE23400 | CASP8AP2 | 9994 | 222201_s_at | 0.6819 | 0.0000 | |
| GSE26886 | CASP8AP2 | 9994 | 222201_s_at | 0.1687 | 0.5622 | |
| GSE29001 | CASP8AP2 | 9994 | 222201_s_at | 0.7488 | 0.0842 | |
| GSE38129 | CASP8AP2 | 9994 | 222201_s_at | 0.5411 | 0.0001 | |
| GSE45670 | CASP8AP2 | 9994 | 222201_s_at | 0.2595 | 0.0803 | |
| GSE53622 | CASP8AP2 | 9994 | 71181 | 0.2546 | 0.0012 | |
| GSE53624 | CASP8AP2 | 9994 | 71181 | 0.3767 | 0.0000 | |
| GSE63941 | CASP8AP2 | 9994 | 222201_s_at | 0.2916 | 0.5829 | |
| GSE77861 | CASP8AP2 | 9994 | 222201_s_at | 0.7591 | 0.0314 | |
| GSE97050 | CASP8AP2 | 9994 | A_33_P3382959 | -0.2032 | 0.4700 | |
| SRP007169 | CASP8AP2 | 9994 | RNAseq | 0.9464 | 0.0027 | |
| SRP008496 | CASP8AP2 | 9994 | RNAseq | 1.0982 | 0.0000 | |
| SRP064894 | CASP8AP2 | 9994 | RNAseq | 0.3239 | 0.3579 | |
| SRP133303 | CASP8AP2 | 9994 | RNAseq | 0.3725 | 0.0260 | |
| SRP159526 | CASP8AP2 | 9994 | RNAseq | 0.2893 | 0.2953 | |
| SRP193095 | CASP8AP2 | 9994 | RNAseq | 0.2117 | 0.0010 | |
| SRP219564 | CASP8AP2 | 9994 | RNAseq | -0.0177 | 0.9428 | |
| TCGA | CASP8AP2 | 9994 | RNAseq | 0.0846 | 0.1473 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by CASP8AP2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CASP8AP2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CASP8AP2 | 9994 | 1 | 4 | 25 | |
| GSE20123 | CASP8AP2 | 9994 | 1 | 3 | 26 | |
| GSE43470 | CASP8AP2 | 9994 | 2 | 1 | 40 | |
| GSE46452 | CASP8AP2 | 9994 | 2 | 11 | 46 | |
| GSE47630 | CASP8AP2 | 9994 | 8 | 6 | 26 | |
| GSE54993 | CASP8AP2 | 9994 | 3 | 2 | 65 | |
| GSE54994 | CASP8AP2 | 9994 | 8 | 10 | 35 | |
| GSE60625 | CASP8AP2 | 9994 | 0 | 1 | 10 | |
| GSE74703 | CASP8AP2 | 9994 | 2 | 1 | 33 | |
| GSE74704 | CASP8AP2 | 9994 | 0 | 2 | 18 | |
| TCGA | CASP8AP2 | 9994 | 6 | 21 | 69 |
Total number of gains: 33; Total number of losses: 62; Total Number of normals: 393.
Somatic mutations of CASP8AP2:
Generating mutation plots.
Highly correlated genes for CASP8AP2:
Showing top 20/1186 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CASP8AP2 | MKLN1 | 0.766222 | 3 | 0 | 3 |
| CASP8AP2 | TTC21B | 0.751153 | 3 | 0 | 3 |
| CASP8AP2 | CCAR1 | 0.738153 | 3 | 0 | 3 |
| CASP8AP2 | CDC42SE2 | 0.736817 | 3 | 0 | 3 |
| CASP8AP2 | NASP | 0.73587 | 7 | 0 | 7 |
| CASP8AP2 | PWP1 | 0.735633 | 3 | 0 | 3 |
| CASP8AP2 | MTMR6 | 0.731001 | 3 | 0 | 3 |
| CASP8AP2 | RTN3 | 0.727958 | 3 | 0 | 3 |
| CASP8AP2 | FBXO30 | 0.726548 | 3 | 0 | 3 |
| CASP8AP2 | ORC3 | 0.722915 | 11 | 0 | 10 |
| CASP8AP2 | KIAA0753 | 0.712216 | 3 | 0 | 3 |
| CASP8AP2 | WDR5 | 0.707421 | 3 | 0 | 3 |
| CASP8AP2 | RBBP4 | 0.706425 | 9 | 0 | 9 |
| CASP8AP2 | ZBTB34 | 0.70387 | 3 | 0 | 3 |
| CASP8AP2 | OGT | 0.703708 | 4 | 0 | 4 |
| CASP8AP2 | ELAVL1 | 0.703502 | 8 | 0 | 8 |
| CASP8AP2 | TMEM60 | 0.701599 | 3 | 0 | 3 |
| CASP8AP2 | MAP4K3 | 0.700863 | 8 | 0 | 7 |
| CASP8AP2 | ALG10B | 0.698332 | 3 | 0 | 3 |
| CASP8AP2 | METTL16 | 0.695748 | 3 | 0 | 3 |
For details and further investigation, click here
