| Full name: origin recognition complex subunit 4 | Alias Symbol: HsORC4|Orc4p | ||
| Type: protein-coding gene | Cytoband: 2q23.1 | ||
| Entrez ID: 5000 | HGNC ID: HGNC:8490 | Ensembl Gene: ENSG00000115947 | OMIM ID: 603056 |
Screen Evidence:
| |||
ORC4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04110 | Cell cycle |
Expression of ORC4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ORC4 | 5000 | 203351_s_at | 0.2589 | 0.3337 | |
| GSE20347 | ORC4 | 5000 | 203351_s_at | 0.0167 | 0.9281 | |
| GSE23400 | ORC4 | 5000 | 203351_s_at | 0.2217 | 0.0000 | |
| GSE26886 | ORC4 | 5000 | 203351_s_at | 0.6573 | 0.0038 | |
| GSE29001 | ORC4 | 5000 | 203351_s_at | -0.0513 | 0.9286 | |
| GSE38129 | ORC4 | 5000 | 203351_s_at | 0.3050 | 0.0093 | |
| GSE45670 | ORC4 | 5000 | 203351_s_at | 0.1866 | 0.2680 | |
| GSE53622 | ORC4 | 5000 | 65186 | 0.0977 | 0.1315 | |
| GSE53624 | ORC4 | 5000 | 65186 | 0.0165 | 0.8131 | |
| GSE63941 | ORC4 | 5000 | 203351_s_at | 0.3871 | 0.4532 | |
| GSE77861 | ORC4 | 5000 | 203351_s_at | 0.1239 | 0.6358 | |
| GSE97050 | ORC4 | 5000 | A_23_P131149 | -0.0960 | 0.6826 | |
| SRP007169 | ORC4 | 5000 | RNAseq | 0.3160 | 0.3436 | |
| SRP008496 | ORC4 | 5000 | RNAseq | 0.5467 | 0.0018 | |
| SRP064894 | ORC4 | 5000 | RNAseq | -0.2577 | 0.0827 | |
| SRP133303 | ORC4 | 5000 | RNAseq | 0.1077 | 0.3529 | |
| SRP159526 | ORC4 | 5000 | RNAseq | 0.5690 | 0.0010 | |
| SRP193095 | ORC4 | 5000 | RNAseq | 0.2327 | 0.0317 | |
| SRP219564 | ORC4 | 5000 | RNAseq | -0.4227 | 0.0849 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ORC4 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of ORC4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ORC4 | 5000 | 4 | 2 | 24 | |
| GSE20123 | ORC4 | 5000 | 4 | 2 | 24 | |
| GSE43470 | ORC4 | 5000 | 3 | 1 | 39 | |
| GSE46452 | ORC4 | 5000 | 1 | 4 | 54 | |
| GSE47630 | ORC4 | 5000 | 5 | 3 | 32 | |
| GSE54993 | ORC4 | 5000 | 0 | 6 | 64 | |
| GSE54994 | ORC4 | 5000 | 11 | 2 | 40 | |
| GSE60625 | ORC4 | 5000 | 0 | 3 | 8 | |
| GSE74703 | ORC4 | 5000 | 2 | 1 | 33 | |
| GSE74704 | ORC4 | 5000 | 3 | 1 | 16 | |
| TCGA | ORC4 | 5000 | 22 | 10 | 64 |
Total number of gains: 55; Total number of losses: 35; Total Number of normals: 398.
Somatic mutations of ORC4:
Generating mutation plots.
Highly correlated genes for ORC4:
Showing top 20/572 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ORC4 | NTPCR | 0.762318 | 4 | 0 | 4 |
| ORC4 | SLC36A4 | 0.753989 | 3 | 0 | 3 |
| ORC4 | MRPL50 | 0.748452 | 5 | 0 | 4 |
| ORC4 | EXOC8 | 0.746656 | 3 | 0 | 3 |
| ORC4 | PDE8A | 0.746407 | 3 | 0 | 3 |
| ORC4 | TMTC3 | 0.741575 | 4 | 0 | 4 |
| ORC4 | CMTM6 | 0.728782 | 3 | 0 | 3 |
| ORC4 | ALS2 | 0.727247 | 4 | 0 | 3 |
| ORC4 | PIK3C3 | 0.72701 | 4 | 0 | 3 |
| ORC4 | XBP1 | 0.725545 | 3 | 0 | 3 |
| ORC4 | DHX37 | 0.720735 | 3 | 0 | 3 |
| ORC4 | RLIM | 0.71995 | 3 | 0 | 3 |
| ORC4 | RBM45 | 0.718239 | 3 | 0 | 3 |
| ORC4 | CHIC1 | 0.717484 | 3 | 0 | 3 |
| ORC4 | NUS1 | 0.715485 | 3 | 0 | 3 |
| ORC4 | TP53I13 | 0.708546 | 3 | 0 | 3 |
| ORC4 | MTRR | 0.702886 | 3 | 0 | 3 |
| ORC4 | CRNKL1 | 0.698959 | 4 | 0 | 3 |
| ORC4 | UTP3 | 0.694501 | 4 | 0 | 3 |
| ORC4 | TTC21B | 0.693839 | 3 | 0 | 3 |
For details and further investigation, click here
