| Full name: suppressor of cytokine signaling 5 | Alias Symbol: KIAA0671|SOCS-5|CIS6|CISH6|Cish5 | ||
| Type: protein-coding gene | Cytoband: 2p21 | ||
| Entrez ID: 9655 | HGNC ID: HGNC:16852 | Ensembl Gene: ENSG00000171150 | OMIM ID: 607094 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
SOCS5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04630 | Jak-STAT signaling pathway | |
| hsa04917 | Prolactin signaling pathway |
Expression of SOCS5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SOCS5 | 9655 | 208127_s_at | -0.2167 | 0.7367 | |
| GSE20347 | SOCS5 | 9655 | 209648_x_at | 0.3220 | 0.1413 | |
| GSE23400 | SOCS5 | 9655 | 209647_s_at | 0.3454 | 0.0000 | |
| GSE26886 | SOCS5 | 9655 | 209647_s_at | 0.0194 | 0.9473 | |
| GSE29001 | SOCS5 | 9655 | 209647_s_at | 0.5854 | 0.0798 | |
| GSE38129 | SOCS5 | 9655 | 208127_s_at | 0.0544 | 0.8264 | |
| GSE45670 | SOCS5 | 9655 | 208127_s_at | -0.4344 | 0.0203 | |
| GSE53622 | SOCS5 | 9655 | 87350 | -0.3022 | 0.0140 | |
| GSE53624 | SOCS5 | 9655 | 87350 | 0.1795 | 0.0314 | |
| GSE63941 | SOCS5 | 9655 | 209647_s_at | -1.1993 | 0.0323 | |
| GSE77861 | SOCS5 | 9655 | 209647_s_at | 0.0656 | 0.8228 | |
| GSE97050 | SOCS5 | 9655 | A_24_P328492 | -0.6447 | 0.1790 | |
| SRP007169 | SOCS5 | 9655 | RNAseq | 1.0645 | 0.0332 | |
| SRP008496 | SOCS5 | 9655 | RNAseq | 1.1159 | 0.0009 | |
| SRP064894 | SOCS5 | 9655 | RNAseq | 0.4959 | 0.0332 | |
| SRP133303 | SOCS5 | 9655 | RNAseq | 0.2734 | 0.0350 | |
| SRP159526 | SOCS5 | 9655 | RNAseq | 0.4858 | 0.0310 | |
| SRP193095 | SOCS5 | 9655 | RNAseq | 0.4451 | 0.0000 | |
| SRP219564 | SOCS5 | 9655 | RNAseq | 0.1400 | 0.6748 | |
| TCGA | SOCS5 | 9655 | RNAseq | -0.0383 | 0.4462 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by SOCS5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SOCS5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SOCS5 | 9655 | 10 | 1 | 19 | |
| GSE20123 | SOCS5 | 9655 | 8 | 1 | 21 | |
| GSE43470 | SOCS5 | 9655 | 5 | 0 | 38 | |
| GSE46452 | SOCS5 | 9655 | 1 | 4 | 54 | |
| GSE47630 | SOCS5 | 9655 | 7 | 0 | 33 | |
| GSE54993 | SOCS5 | 9655 | 0 | 5 | 65 | |
| GSE54994 | SOCS5 | 9655 | 10 | 0 | 43 | |
| GSE60625 | SOCS5 | 9655 | 0 | 3 | 8 | |
| GSE74703 | SOCS5 | 9655 | 5 | 0 | 31 | |
| GSE74704 | SOCS5 | 9655 | 9 | 1 | 10 | |
| TCGA | SOCS5 | 9655 | 35 | 2 | 59 |
Total number of gains: 90; Total number of losses: 17; Total Number of normals: 381.
Somatic mutations of SOCS5:
Generating mutation plots.
Highly correlated genes for SOCS5:
Showing top 20/904 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SOCS5 | DNAJB6 | 0.761544 | 3 | 0 | 3 |
| SOCS5 | HIPK1 | 0.758428 | 3 | 0 | 3 |
| SOCS5 | INTU | 0.730683 | 3 | 0 | 3 |
| SOCS5 | KLHDC9 | 0.727085 | 3 | 0 | 3 |
| SOCS5 | TCF7L1 | 0.715483 | 6 | 0 | 6 |
| SOCS5 | THAP2 | 0.713195 | 3 | 0 | 3 |
| SOCS5 | PCMTD1 | 0.709853 | 3 | 0 | 3 |
| SOCS5 | TWISTNB | 0.699463 | 4 | 0 | 4 |
| SOCS5 | MXRA7 | 0.697044 | 7 | 0 | 6 |
| SOCS5 | DNAJC8 | 0.696449 | 5 | 0 | 4 |
| SOCS5 | PRKG2 | 0.695549 | 3 | 0 | 3 |
| SOCS5 | FUNDC2 | 0.686013 | 4 | 0 | 4 |
| SOCS5 | SNAPC3 | 0.683173 | 4 | 0 | 4 |
| SOCS5 | CLDN12 | 0.679261 | 3 | 0 | 3 |
| SOCS5 | SORCS1 | 0.678466 | 3 | 0 | 3 |
| SOCS5 | HADHB | 0.677703 | 4 | 0 | 3 |
| SOCS5 | PRADC1 | 0.677091 | 3 | 0 | 3 |
| SOCS5 | ROCK2 | 0.67688 | 9 | 0 | 9 |
| SOCS5 | EIF3A | 0.674674 | 3 | 0 | 3 |
| SOCS5 | TTC21B | 0.673489 | 3 | 0 | 3 |
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