| Full name: xanthine dehydrogenase | Alias Symbol: XOR|XO | ||
| Type: protein-coding gene | Cytoband: 2p23.1 | ||
| Entrez ID: 7498 | HGNC ID: HGNC:12805 | Ensembl Gene: ENSG00000158125 | OMIM ID: 607633 |
| Drug and gene relationship at DGIdb | |||
Expression of XDH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | XDH | 7498 | 241994_at | -0.2264 | 0.9233 | |
| GSE20347 | XDH | 7498 | 210301_at | -0.1791 | 0.2404 | |
| GSE23400 | XDH | 7498 | 210301_at | -0.2360 | 0.0005 | |
| GSE26886 | XDH | 7498 | 241994_at | -1.3230 | 0.0387 | |
| GSE29001 | XDH | 7498 | 210301_at | -0.3008 | 0.1341 | |
| GSE38129 | XDH | 7498 | 210301_at | -0.2198 | 0.2055 | |
| GSE45670 | XDH | 7498 | 241994_at | 2.1243 | 0.0002 | |
| GSE53622 | XDH | 7498 | 11802 | 0.2519 | 0.1877 | |
| GSE53624 | XDH | 7498 | 11802 | -0.6102 | 0.0001 | |
| GSE63941 | XDH | 7498 | 241994_at | 1.8189 | 0.0085 | |
| GSE77861 | XDH | 7498 | 241994_at | -0.1118 | 0.8771 | |
| GSE97050 | XDH | 7498 | A_33_P3270863 | 1.0991 | 0.1377 | |
| SRP007169 | XDH | 7498 | RNAseq | -3.5253 | 0.0000 | |
| SRP008496 | XDH | 7498 | RNAseq | -3.9613 | 0.0000 | |
| SRP064894 | XDH | 7498 | RNAseq | -0.1806 | 0.6695 | |
| SRP133303 | XDH | 7498 | RNAseq | 0.4042 | 0.0381 | |
| SRP159526 | XDH | 7498 | RNAseq | -1.4666 | 0.0027 | |
| SRP193095 | XDH | 7498 | RNAseq | -0.0804 | 0.8175 | |
| SRP219564 | XDH | 7498 | RNAseq | -0.2080 | 0.8359 | |
| TCGA | XDH | 7498 | RNAseq | 1.0422 | 0.0001 |
Upregulated datasets: 3; Downregulated datasets: 4.
Survival by XDH expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of XDH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | XDH | 7498 | 10 | 1 | 19 | |
| GSE20123 | XDH | 7498 | 9 | 1 | 20 | |
| GSE43470 | XDH | 7498 | 2 | 1 | 40 | |
| GSE46452 | XDH | 7498 | 2 | 4 | 53 | |
| GSE47630 | XDH | 7498 | 8 | 0 | 32 | |
| GSE54993 | XDH | 7498 | 0 | 5 | 65 | |
| GSE54994 | XDH | 7498 | 10 | 0 | 43 | |
| GSE60625 | XDH | 7498 | 0 | 3 | 8 | |
| GSE74703 | XDH | 7498 | 2 | 0 | 34 | |
| GSE74704 | XDH | 7498 | 9 | 1 | 10 | |
| TCGA | XDH | 7498 | 36 | 2 | 58 |
Total number of gains: 88; Total number of losses: 18; Total Number of normals: 382.
Somatic mutations of XDH:
Generating mutation plots.
Highly correlated genes for XDH:
Showing top 20/472 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| XDH | BTNL3 | 0.689737 | 4 | 0 | 4 |
| XDH | E2F4 | 0.686221 | 5 | 0 | 5 |
| XDH | CLCA1 | 0.681821 | 3 | 0 | 3 |
| XDH | PHLDB1 | 0.681605 | 4 | 0 | 4 |
| XDH | SLC28A2 | 0.677503 | 4 | 0 | 4 |
| XDH | IL1RAPL2 | 0.665756 | 4 | 0 | 3 |
| XDH | TOR4A | 0.66546 | 4 | 0 | 4 |
| XDH | KIAA1217 | 0.658568 | 4 | 0 | 4 |
| XDH | PIWIL2 | 0.657648 | 5 | 0 | 5 |
| XDH | ARMC4 | 0.655885 | 4 | 0 | 4 |
| XDH | MYOG | 0.653378 | 4 | 0 | 3 |
| XDH | ATXN2L | 0.65323 | 3 | 0 | 3 |
| XDH | PFKFB2 | 0.649498 | 3 | 0 | 3 |
| XDH | NPHS2 | 0.649425 | 4 | 0 | 4 |
| XDH | FAM83A | 0.647534 | 8 | 0 | 7 |
| XDH | IL9R | 0.64711 | 5 | 0 | 4 |
| XDH | CAPN11 | 0.646931 | 3 | 0 | 3 |
| XDH | SERPINA6 | 0.644815 | 4 | 0 | 4 |
| XDH | GLP1R | 0.643896 | 5 | 0 | 4 |
| XDH | C8B | 0.639686 | 4 | 0 | 3 |
For details and further investigation, click here
