| Full name: glucagon like peptide 1 receptor | Alias Symbol: GLP-1R | ||
| Type: protein-coding gene | Cytoband: 6p21.2 | ||
| Entrez ID: 2740 | HGNC ID: HGNC:4324 | Ensembl Gene: ENSG00000112164 | OMIM ID: 138032 |
| Drug and gene relationship at DGIdb | |||
GLP1R involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04024 | cAMP signaling pathway | |
| hsa04911 | Insulin secretion |
Expression of GLP1R:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GLP1R | 2740 | 208390_s_at | 0.0968 | 0.6659 | |
| GSE20347 | GLP1R | 2740 | 208390_s_at | 0.0646 | 0.6069 | |
| GSE23400 | GLP1R | 2740 | 208390_s_at | -0.0896 | 0.0128 | |
| GSE26886 | GLP1R | 2740 | 208390_s_at | 0.1135 | 0.4037 | |
| GSE29001 | GLP1R | 2740 | 208390_s_at | -0.1512 | 0.5536 | |
| GSE38129 | GLP1R | 2740 | 208390_s_at | -0.0970 | 0.5536 | |
| GSE45670 | GLP1R | 2740 | 208390_s_at | -0.0314 | 0.8044 | |
| GSE53622 | GLP1R | 2740 | 4577 | -0.7116 | 0.0398 | |
| GSE53624 | GLP1R | 2740 | 106278 | -0.2144 | 0.1253 | |
| GSE63941 | GLP1R | 2740 | 208390_s_at | 0.5988 | 0.0086 | |
| GSE77861 | GLP1R | 2740 | 208390_s_at | -0.0110 | 0.9314 | |
| TCGA | GLP1R | 2740 | RNAseq | -2.8758 | 0.0009 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by GLP1R expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GLP1R:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GLP1R | 2740 | 4 | 2 | 24 | |
| GSE20123 | GLP1R | 2740 | 4 | 2 | 24 | |
| GSE43470 | GLP1R | 2740 | 6 | 0 | 37 | |
| GSE46452 | GLP1R | 2740 | 2 | 9 | 48 | |
| GSE47630 | GLP1R | 2740 | 8 | 4 | 28 | |
| GSE54993 | GLP1R | 2740 | 3 | 2 | 65 | |
| GSE54994 | GLP1R | 2740 | 11 | 4 | 38 | |
| GSE60625 | GLP1R | 2740 | 0 | 1 | 10 | |
| GSE74703 | GLP1R | 2740 | 6 | 0 | 30 | |
| GSE74704 | GLP1R | 2740 | 1 | 2 | 17 | |
| TCGA | GLP1R | 2740 | 18 | 13 | 65 |
Total number of gains: 63; Total number of losses: 39; Total Number of normals: 386.
Somatic mutations of GLP1R:
Generating mutation plots.
Highly correlated genes for GLP1R:
Showing top 20/1252 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GLP1R | PNPLA2 | 0.755694 | 7 | 0 | 7 |
| GLP1R | DLL4 | 0.749255 | 4 | 0 | 4 |
| GLP1R | HSPB6 | 0.730762 | 3 | 0 | 3 |
| GLP1R | FOXN3-AS2 | 0.730201 | 5 | 0 | 5 |
| GLP1R | BCAN | 0.723143 | 7 | 0 | 7 |
| GLP1R | KIR2DL5A | 0.718144 | 6 | 0 | 6 |
| GLP1R | CLCA1 | 0.715593 | 6 | 0 | 6 |
| GLP1R | SLC1A6 | 0.714162 | 5 | 0 | 5 |
| GLP1R | NXPE4 | 0.713477 | 5 | 0 | 5 |
| GLP1R | LENEP | 0.712523 | 6 | 0 | 6 |
| GLP1R | OPHN1 | 0.708922 | 5 | 0 | 5 |
| GLP1R | TMEM212 | 0.708653 | 3 | 0 | 3 |
| GLP1R | LINC00520 | 0.706225 | 3 | 0 | 3 |
| GLP1R | ZNF460 | 0.704479 | 4 | 0 | 3 |
| GLP1R | BRINP2 | 0.703624 | 4 | 0 | 4 |
| GLP1R | NUDT7 | 0.7 | 4 | 0 | 3 |
| GLP1R | CIITA | 0.69929 | 6 | 0 | 6 |
| GLP1R | FCGR2C | 0.694737 | 3 | 0 | 3 |
| GLP1R | SERPINA6 | 0.693954 | 4 | 0 | 4 |
| GLP1R | LKAAEAR1 | 0.693352 | 3 | 0 | 3 |
For details and further investigation, click here
