| Full name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q32.1 | ||
| Entrez ID: 5208 | HGNC ID: HGNC:8873 | Ensembl Gene: ENSG00000123836 | OMIM ID: 171835 |
| Drug and gene relationship at DGIdb | |||
PFKFB2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04152 | AMPK signaling pathway | |
| hsa04919 | Thyroid hormone signaling pathway |
Expression of PFKFB2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PFKFB2 | 5208 | 226733_at | 0.3740 | 0.6279 | |
| GSE20347 | PFKFB2 | 5208 | 207931_s_at | -0.2426 | 0.0006 | |
| GSE23400 | PFKFB2 | 5208 | 207931_s_at | -0.1852 | 0.0000 | |
| GSE26886 | PFKFB2 | 5208 | 226733_at | -1.1891 | 0.0074 | |
| GSE29001 | PFKFB2 | 5208 | 207931_s_at | -0.2956 | 0.0352 | |
| GSE38129 | PFKFB2 | 5208 | 207931_s_at | -0.2273 | 0.0068 | |
| GSE45670 | PFKFB2 | 5208 | 226733_at | -0.6845 | 0.0052 | |
| GSE53622 | PFKFB2 | 5208 | 83721 | -0.1127 | 0.1348 | |
| GSE53624 | PFKFB2 | 5208 | 83721 | 0.0033 | 0.9756 | |
| GSE63941 | PFKFB2 | 5208 | 226733_at | 0.0751 | 0.9238 | |
| GSE77861 | PFKFB2 | 5208 | 207931_s_at | -0.1949 | 0.0366 | |
| GSE97050 | PFKFB2 | 5208 | A_33_P3300635 | -0.1973 | 0.7042 | |
| SRP007169 | PFKFB2 | 5208 | RNAseq | -1.5385 | 0.0118 | |
| SRP008496 | PFKFB2 | 5208 | RNAseq | -1.3761 | 0.0007 | |
| SRP064894 | PFKFB2 | 5208 | RNAseq | -1.3438 | 0.0000 | |
| SRP133303 | PFKFB2 | 5208 | RNAseq | -0.8378 | 0.0000 | |
| SRP159526 | PFKFB2 | 5208 | RNAseq | -0.7720 | 0.0738 | |
| SRP193095 | PFKFB2 | 5208 | RNAseq | -1.2782 | 0.0000 | |
| SRP219564 | PFKFB2 | 5208 | RNAseq | -1.1703 | 0.0542 | |
| TCGA | PFKFB2 | 5208 | RNAseq | -0.3187 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by PFKFB2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PFKFB2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PFKFB2 | 5208 | 11 | 0 | 19 | |
| GSE20123 | PFKFB2 | 5208 | 11 | 0 | 19 | |
| GSE43470 | PFKFB2 | 5208 | 8 | 0 | 35 | |
| GSE46452 | PFKFB2 | 5208 | 3 | 1 | 55 | |
| GSE47630 | PFKFB2 | 5208 | 14 | 0 | 26 | |
| GSE54993 | PFKFB2 | 5208 | 0 | 6 | 64 | |
| GSE54994 | PFKFB2 | 5208 | 14 | 0 | 39 | |
| GSE60625 | PFKFB2 | 5208 | 0 | 0 | 11 | |
| GSE74703 | PFKFB2 | 5208 | 8 | 0 | 28 | |
| GSE74704 | PFKFB2 | 5208 | 5 | 0 | 15 | |
| TCGA | PFKFB2 | 5208 | 45 | 3 | 48 |
Total number of gains: 119; Total number of losses: 10; Total Number of normals: 359.
Somatic mutations of PFKFB2:
Generating mutation plots.
Highly correlated genes for PFKFB2:
Showing top 20/1087 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PFKFB2 | ZNF654 | 0.793608 | 3 | 0 | 3 |
| PFKFB2 | CTTNBP2NL | 0.790851 | 4 | 0 | 4 |
| PFKFB2 | TRAPPC6B | 0.776327 | 3 | 0 | 3 |
| PFKFB2 | LYSMD3 | 0.768792 | 3 | 0 | 3 |
| PFKFB2 | CPEB4 | 0.752947 | 4 | 0 | 4 |
| PFKFB2 | ZNF662 | 0.73111 | 4 | 0 | 4 |
| PFKFB2 | HEATR5A | 0.730413 | 4 | 0 | 4 |
| PFKFB2 | PSMC6 | 0.727544 | 3 | 0 | 3 |
| PFKFB2 | WDR26 | 0.72581 | 7 | 0 | 6 |
| PFKFB2 | RNF208 | 0.71979 | 6 | 0 | 6 |
| PFKFB2 | ZFAND2B | 0.717738 | 4 | 0 | 4 |
| PFKFB2 | ZNF844 | 0.715571 | 4 | 0 | 4 |
| PFKFB2 | GRPEL2 | 0.715307 | 4 | 0 | 4 |
| PFKFB2 | CSNK1A1 | 0.711055 | 5 | 0 | 5 |
| PFKFB2 | ZNF506 | 0.710997 | 5 | 0 | 3 |
| PFKFB2 | PADI1 | 0.710545 | 7 | 0 | 7 |
| PFKFB2 | OR2T33 | 0.708305 | 3 | 0 | 3 |
| PFKFB2 | UBE2D2 | 0.70812 | 3 | 0 | 3 |
| PFKFB2 | ZFYVE1 | 0.707183 | 4 | 0 | 4 |
| PFKFB2 | ABHD5 | 0.706919 | 7 | 0 | 7 |
For details and further investigation, click here
