| Full name: E2F transcription factor 4 | Alias Symbol: E2F-4 | ||
| Type: protein-coding gene | Cytoband: 16q22.1 | ||
| Entrez ID: 1874 | HGNC ID: HGNC:3118 | Ensembl Gene: ENSG00000205250 | OMIM ID: 600659 |
| Drug and gene relationship at DGIdb | |||
E2F4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04110 | Cell cycle | |
| hsa04350 | TGF-beta signaling pathway |
Expression of E2F4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | E2F4 | 1874 | 38707_r_at | -0.0806 | 0.8317 | |
| GSE20347 | E2F4 | 1874 | 38707_r_at | -0.0509 | 0.6403 | |
| GSE23400 | E2F4 | 1874 | 38707_r_at | -0.1176 | 0.0000 | |
| GSE26886 | E2F4 | 1874 | 38707_r_at | -0.4284 | 0.0159 | |
| GSE29001 | E2F4 | 1874 | 38707_r_at | -0.3366 | 0.0735 | |
| GSE38129 | E2F4 | 1874 | 38707_r_at | -0.2116 | 0.0688 | |
| GSE45670 | E2F4 | 1874 | 38707_r_at | -0.1031 | 0.2471 | |
| GSE53622 | E2F4 | 1874 | 52911 | 0.5985 | 0.0000 | |
| GSE53624 | E2F4 | 1874 | 52911 | 0.6250 | 0.0000 | |
| GSE63941 | E2F4 | 1874 | 38707_r_at | 1.0426 | 0.0001 | |
| GSE77861 | E2F4 | 1874 | 38707_r_at | -0.1432 | 0.3207 | |
| GSE97050 | E2F4 | 1874 | A_23_P152218 | 0.5614 | 0.1399 | |
| SRP007169 | E2F4 | 1874 | RNAseq | 0.5921 | 0.0787 | |
| SRP008496 | E2F4 | 1874 | RNAseq | 0.7049 | 0.0148 | |
| SRP064894 | E2F4 | 1874 | RNAseq | 0.2406 | 0.0499 | |
| SRP133303 | E2F4 | 1874 | RNAseq | 0.6746 | 0.0001 | |
| SRP159526 | E2F4 | 1874 | RNAseq | 0.6332 | 0.0040 | |
| SRP193095 | E2F4 | 1874 | RNAseq | 0.6377 | 0.0000 | |
| SRP219564 | E2F4 | 1874 | RNAseq | 0.2752 | 0.3393 | |
| TCGA | E2F4 | 1874 | RNAseq | 0.1701 | 0.0004 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by E2F4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of E2F4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | E2F4 | 1874 | 9 | 2 | 19 | |
| GSE20123 | E2F4 | 1874 | 9 | 2 | 19 | |
| GSE43470 | E2F4 | 1874 | 1 | 9 | 33 | |
| GSE46452 | E2F4 | 1874 | 38 | 1 | 20 | |
| GSE47630 | E2F4 | 1874 | 10 | 8 | 22 | |
| GSE54993 | E2F4 | 1874 | 2 | 4 | 64 | |
| GSE54994 | E2F4 | 1874 | 8 | 10 | 35 | |
| GSE60625 | E2F4 | 1874 | 4 | 0 | 7 | |
| GSE74703 | E2F4 | 1874 | 1 | 6 | 29 | |
| GSE74704 | E2F4 | 1874 | 5 | 1 | 14 | |
| TCGA | E2F4 | 1874 | 29 | 12 | 55 |
Total number of gains: 116; Total number of losses: 55; Total Number of normals: 317.
Somatic mutations of E2F4:
Generating mutation plots.
Highly correlated genes for E2F4:
Showing top 20/959 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| E2F4 | C11orf68 | 0.814536 | 3 | 0 | 3 |
| E2F4 | COX15 | 0.804236 | 3 | 0 | 3 |
| E2F4 | OPHN1 | 0.798925 | 7 | 0 | 7 |
| E2F4 | GABRR2 | 0.783026 | 5 | 0 | 5 |
| E2F4 | SRP68 | 0.77871 | 3 | 0 | 3 |
| E2F4 | DNAH1 | 0.774696 | 5 | 0 | 5 |
| E2F4 | MTHFD1L | 0.772086 | 3 | 0 | 3 |
| E2F4 | MTAP | 0.763077 | 5 | 0 | 5 |
| E2F4 | PLCD3 | 0.752994 | 4 | 0 | 4 |
| E2F4 | HHLA1 | 0.731672 | 8 | 0 | 7 |
| E2F4 | MPV17L | 0.727796 | 5 | 0 | 4 |
| E2F4 | ZNF619 | 0.726019 | 3 | 0 | 3 |
| E2F4 | SLC28A2 | 0.72205 | 6 | 0 | 6 |
| E2F4 | FAM89A | 0.716296 | 3 | 0 | 3 |
| E2F4 | LRRC8C | 0.714741 | 3 | 0 | 3 |
| E2F4 | KLF14 | 0.714375 | 5 | 0 | 4 |
| E2F4 | ODF1 | 0.713497 | 6 | 0 | 6 |
| E2F4 | FBXO16 | 0.713045 | 3 | 0 | 3 |
| E2F4 | TMEM95 | 0.710306 | 4 | 0 | 4 |
| E2F4 | NUMA1 | 0.709186 | 3 | 0 | 3 |
For details and further investigation, click here
