| Full name: zinc finger protein 486 | Alias Symbol: MGC2396 | ||
| Type: protein-coding gene | Cytoband: 19p12 | ||
| Entrez ID: 90649 | HGNC ID: HGNC:20807 | Ensembl Gene: ENSG00000256229 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ZNF486:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ZNF486 | 90649 | 1553901_x_at | -0.1390 | 0.5479 | |
| GSE26886 | ZNF486 | 90649 | 1553901_x_at | -0.1226 | 0.3597 | |
| GSE45670 | ZNF486 | 90649 | 1553901_x_at | -0.0061 | 0.9530 | |
| GSE53622 | ZNF486 | 90649 | 147716 | -0.3728 | 0.0001 | |
| GSE53624 | ZNF486 | 90649 | 147716 | -0.3183 | 0.0000 | |
| GSE63941 | ZNF486 | 90649 | 1553901_x_at | 0.0481 | 0.7517 | |
| GSE77861 | ZNF486 | 90649 | 1553901_x_at | -0.1909 | 0.4338 | |
| GSE97050 | ZNF486 | 90649 | A_24_P100016 | -0.5785 | 0.1663 | |
| SRP007169 | ZNF486 | 90649 | RNAseq | -2.4541 | 0.0000 | |
| SRP008496 | ZNF486 | 90649 | RNAseq | -2.2566 | 0.0000 | |
| SRP064894 | ZNF486 | 90649 | RNAseq | -0.3005 | 0.3981 | |
| SRP133303 | ZNF486 | 90649 | RNAseq | -0.5636 | 0.0061 | |
| SRP159526 | ZNF486 | 90649 | RNAseq | -1.2469 | 0.0168 | |
| SRP193095 | ZNF486 | 90649 | RNAseq | -0.3104 | 0.1377 | |
| SRP219564 | ZNF486 | 90649 | RNAseq | 0.7773 | 0.2606 | |
| TCGA | ZNF486 | 90649 | RNAseq | -0.6433 | 0.0823 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by ZNF486 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ZNF486:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ZNF486 | 90649 | 3 | 5 | 22 | |
| GSE20123 | ZNF486 | 90649 | 3 | 3 | 24 | |
| GSE43470 | ZNF486 | 90649 | 2 | 6 | 35 | |
| GSE46452 | ZNF486 | 90649 | 47 | 1 | 11 | |
| GSE47630 | ZNF486 | 90649 | 5 | 8 | 27 | |
| GSE54993 | ZNF486 | 90649 | 17 | 3 | 50 | |
| GSE54994 | ZNF486 | 90649 | 6 | 13 | 34 | |
| GSE60625 | ZNF486 | 90649 | 9 | 0 | 2 | |
| GSE74703 | ZNF486 | 90649 | 2 | 4 | 30 | |
| GSE74704 | ZNF486 | 90649 | 0 | 3 | 17 | |
| TCGA | ZNF486 | 90649 | 16 | 12 | 68 |
Total number of gains: 110; Total number of losses: 58; Total Number of normals: 320.
Somatic mutations of ZNF486:
Generating mutation plots.
Highly correlated genes for ZNF486:
Showing top 20/36 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ZNF486 | ZNF738 | 0.786116 | 3 | 0 | 3 |
| ZNF486 | ZNF732 | 0.736071 | 3 | 0 | 3 |
| ZNF486 | ZNF92 | 0.712425 | 3 | 0 | 3 |
| ZNF486 | ZNF85 | 0.681755 | 5 | 0 | 4 |
| ZNF486 | ZNF99 | 0.675914 | 4 | 0 | 4 |
| ZNF486 | ANKHD1 | 0.672347 | 3 | 0 | 3 |
| ZNF486 | ZNF479 | 0.670648 | 3 | 0 | 3 |
| ZNF486 | SFTPB | 0.651494 | 3 | 0 | 3 |
| ZNF486 | IL18 | 0.644468 | 4 | 0 | 3 |
| ZNF486 | ZNF93 | 0.641175 | 5 | 0 | 5 |
| ZNF486 | DAPP1 | 0.628767 | 5 | 0 | 3 |
| ZNF486 | GPR1 | 0.628726 | 4 | 0 | 4 |
| ZNF486 | ZNF273 | 0.604375 | 5 | 0 | 4 |
| ZNF486 | ZNF493 | 0.602591 | 6 | 0 | 4 |
| ZNF486 | FAM161B | 0.600361 | 4 | 0 | 4 |
| ZNF486 | ZNF430 | 0.592049 | 7 | 0 | 3 |
| ZNF486 | PHACTR2 | 0.575662 | 4 | 0 | 3 |
| ZNF486 | LRRFIP1 | 0.573638 | 4 | 0 | 3 |
| ZNF486 | UACA | 0.567855 | 4 | 0 | 3 |
| ZNF486 | FOXP1-IT1 | 0.567148 | 4 | 0 | 3 |
For details and further investigation, click here
