| Full name: interleukin 18 | Alias Symbol: IGIF|IL1F4|IL-1g|IL-18 | ||
| Type: protein-coding gene | Cytoband: 11q23.1 | ||
| Entrez ID: 3606 | HGNC ID: HGNC:5986 | Ensembl Gene: ENSG00000150782 | OMIM ID: 600953 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
IL18 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05132 | Salmonella infection | |
| hsa05134 | Legionellosis | |
| hsa05152 | Tuberculosis | |
| hsa05164 | Influenza A | |
| hsa05321 | Inflammatory bowel disease (IBD) |
Expression of IL18:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IL18 | 3606 | 206295_at | -2.0915 | 0.1159 | |
| GSE20347 | IL18 | 3606 | 206295_at | -3.1242 | 0.0000 | |
| GSE23400 | IL18 | 3606 | 206295_at | -2.1735 | 0.0000 | |
| GSE26886 | IL18 | 3606 | 206295_at | -4.6604 | 0.0000 | |
| GSE29001 | IL18 | 3606 | 206295_at | -3.1637 | 0.0000 | |
| GSE38129 | IL18 | 3606 | 206295_at | -2.4368 | 0.0001 | |
| GSE45670 | IL18 | 3606 | 206295_at | -1.7964 | 0.0000 | |
| GSE53622 | IL18 | 3606 | 5089 | -2.3418 | 0.0000 | |
| GSE53624 | IL18 | 3606 | 5089 | -2.8916 | 0.0000 | |
| GSE63941 | IL18 | 3606 | 206295_at | 1.3350 | 0.3092 | |
| GSE77861 | IL18 | 3606 | 206295_at | -2.9929 | 0.0018 | |
| GSE97050 | IL18 | 3606 | A_23_P104798 | -0.6287 | 0.7405 | |
| SRP007169 | IL18 | 3606 | RNAseq | -5.2546 | 0.0000 | |
| SRP008496 | IL18 | 3606 | RNAseq | -4.9167 | 0.0000 | |
| SRP064894 | IL18 | 3606 | RNAseq | -3.7140 | 0.0000 | |
| SRP133303 | IL18 | 3606 | RNAseq | -2.5992 | 0.0000 | |
| SRP159526 | IL18 | 3606 | RNAseq | -3.5364 | 0.0000 | |
| SRP193095 | IL18 | 3606 | RNAseq | -3.3280 | 0.0000 | |
| SRP219564 | IL18 | 3606 | RNAseq | -2.9587 | 0.0008 | |
| TCGA | IL18 | 3606 | RNAseq | 0.1747 | 0.3104 |
Upregulated datasets: 0; Downregulated datasets: 16.
Survival by IL18 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IL18:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IL18 | 3606 | 0 | 12 | 18 | |
| GSE20123 | IL18 | 3606 | 0 | 12 | 18 | |
| GSE43470 | IL18 | 3606 | 2 | 6 | 35 | |
| GSE46452 | IL18 | 3606 | 3 | 26 | 30 | |
| GSE47630 | IL18 | 3606 | 2 | 19 | 19 | |
| GSE54993 | IL18 | 3606 | 10 | 0 | 60 | |
| GSE54994 | IL18 | 3606 | 5 | 19 | 29 | |
| GSE60625 | IL18 | 3606 | 0 | 3 | 8 | |
| GSE74703 | IL18 | 3606 | 1 | 4 | 31 | |
| GSE74704 | IL18 | 3606 | 0 | 8 | 12 | |
| TCGA | IL18 | 3606 | 7 | 48 | 41 |
Total number of gains: 30; Total number of losses: 157; Total Number of normals: 301.
Somatic mutations of IL18:
Generating mutation plots.
Highly correlated genes for IL18:
Showing top 20/1315 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IL18 | CYSRT1 | 0.874109 | 6 | 0 | 6 |
| IL18 | SCEL | 0.869389 | 11 | 0 | 11 |
| IL18 | S100A14 | 0.863367 | 11 | 0 | 11 |
| IL18 | C1orf116 | 0.857817 | 11 | 0 | 11 |
| IL18 | TMOD3 | 0.857566 | 11 | 0 | 11 |
| IL18 | GYS2 | 0.854922 | 10 | 0 | 10 |
| IL18 | ECM1 | 0.853808 | 11 | 0 | 11 |
| IL18 | MXD1 | 0.853392 | 11 | 0 | 11 |
| IL18 | FCHO2 | 0.852543 | 6 | 0 | 6 |
| IL18 | CRCT1 | 0.850119 | 11 | 0 | 11 |
| IL18 | GDPD3 | 0.848144 | 11 | 0 | 11 |
| IL18 | CLIC3 | 0.846149 | 9 | 0 | 9 |
| IL18 | TRIP10 | 0.844926 | 10 | 0 | 10 |
| IL18 | S100A16 | 0.844249 | 7 | 0 | 7 |
| IL18 | PTK6 | 0.843047 | 11 | 0 | 11 |
| IL18 | MALL | 0.841564 | 11 | 0 | 11 |
| IL18 | ENDOU | 0.839355 | 11 | 0 | 10 |
| IL18 | PDLIM2 | 0.837483 | 8 | 0 | 8 |
| IL18 | SLC16A6 | 0.836095 | 10 | 0 | 10 |
| IL18 | SLURP1 | 0.835742 | 11 | 0 | 11 |
For details and further investigation, click here
