| Full name: phosphatase and actin regulator 2 | Alias Symbol: KIAA0680 | ||
| Type: protein-coding gene | Cytoband: 6q24.2 | ||
| Entrez ID: 9749 | HGNC ID: HGNC:20956 | Ensembl Gene: ENSG00000112419 | OMIM ID: 608724 |
| Drug and gene relationship at DGIdb | |||
Expression of PHACTR2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PHACTR2 | 9749 | 204048_s_at | -1.1577 | 0.0602 | |
| GSE20347 | PHACTR2 | 9749 | 204048_s_at | -1.7663 | 0.0000 | |
| GSE23400 | PHACTR2 | 9749 | 204048_s_at | -1.3947 | 0.0000 | |
| GSE26886 | PHACTR2 | 9749 | 204048_s_at | -3.3133 | 0.0000 | |
| GSE29001 | PHACTR2 | 9749 | 204048_s_at | -1.6917 | 0.0005 | |
| GSE38129 | PHACTR2 | 9749 | 204048_s_at | -1.6214 | 0.0000 | |
| GSE45670 | PHACTR2 | 9749 | 204048_s_at | -1.2679 | 0.0000 | |
| GSE53622 | PHACTR2 | 9749 | 163302 | -2.1037 | 0.0000 | |
| GSE53624 | PHACTR2 | 9749 | 163302 | -2.1057 | 0.0000 | |
| GSE63941 | PHACTR2 | 9749 | 204049_s_at | -1.2323 | 0.1280 | |
| GSE77861 | PHACTR2 | 9749 | 204049_s_at | -0.9632 | 0.1374 | |
| GSE97050 | PHACTR2 | 9749 | A_33_P3321050 | -1.3012 | 0.1805 | |
| SRP007169 | PHACTR2 | 9749 | RNAseq | -2.3349 | 0.0000 | |
| SRP008496 | PHACTR2 | 9749 | RNAseq | -2.1720 | 0.0000 | |
| SRP064894 | PHACTR2 | 9749 | RNAseq | -2.1627 | 0.0000 | |
| SRP133303 | PHACTR2 | 9749 | RNAseq | -1.3144 | 0.0000 | |
| SRP159526 | PHACTR2 | 9749 | RNAseq | -1.8253 | 0.0000 | |
| SRP193095 | PHACTR2 | 9749 | RNAseq | -1.5766 | 0.0000 | |
| SRP219564 | PHACTR2 | 9749 | RNAseq | -1.6657 | 0.0023 | |
| TCGA | PHACTR2 | 9749 | RNAseq | -0.3637 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 15.
Survival by PHACTR2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PHACTR2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PHACTR2 | 9749 | 2 | 4 | 24 | |
| GSE20123 | PHACTR2 | 9749 | 2 | 3 | 25 | |
| GSE43470 | PHACTR2 | 9749 | 5 | 0 | 38 | |
| GSE46452 | PHACTR2 | 9749 | 3 | 10 | 46 | |
| GSE47630 | PHACTR2 | 9749 | 9 | 4 | 27 | |
| GSE54993 | PHACTR2 | 9749 | 3 | 2 | 65 | |
| GSE54994 | PHACTR2 | 9749 | 8 | 8 | 37 | |
| GSE60625 | PHACTR2 | 9749 | 0 | 1 | 10 | |
| GSE74703 | PHACTR2 | 9749 | 4 | 0 | 32 | |
| GSE74704 | PHACTR2 | 9749 | 0 | 1 | 19 | |
| TCGA | PHACTR2 | 9749 | 11 | 20 | 65 |
Total number of gains: 47; Total number of losses: 53; Total Number of normals: 388.
Somatic mutations of PHACTR2:
Generating mutation plots.
Highly correlated genes for PHACTR2:
Showing top 20/1570 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PHACTR2 | NUCB2 | 0.835778 | 11 | 0 | 11 |
| PHACTR2 | EPS8L1 | 0.830187 | 11 | 0 | 11 |
| PHACTR2 | CRISP3 | 0.828128 | 11 | 0 | 11 |
| PHACTR2 | TMOD3 | 0.826386 | 11 | 0 | 11 |
| PHACTR2 | UBL3 | 0.825549 | 11 | 0 | 11 |
| PHACTR2 | SMIM5 | 0.825231 | 6 | 0 | 6 |
| PHACTR2 | EPGN | 0.824363 | 3 | 0 | 3 |
| PHACTR2 | CYSRT1 | 0.823706 | 6 | 0 | 6 |
| PHACTR2 | GYS2 | 0.822059 | 10 | 0 | 10 |
| PHACTR2 | ECM1 | 0.821326 | 11 | 0 | 11 |
| PHACTR2 | LRRFIP2 | 0.818675 | 10 | 0 | 10 |
| PHACTR2 | MAL | 0.81808 | 11 | 0 | 11 |
| PHACTR2 | C18orf25 | 0.817178 | 11 | 0 | 11 |
| PHACTR2 | RANBP9 | 0.815967 | 11 | 0 | 11 |
| PHACTR2 | KRT78 | 0.811245 | 8 | 0 | 7 |
| PHACTR2 | FAM3D | 0.809289 | 7 | 0 | 7 |
| PHACTR2 | ENDOU | 0.809082 | 11 | 0 | 11 |
| PHACTR2 | SPINK7 | 0.805684 | 7 | 0 | 7 |
| PHACTR2 | YOD1 | 0.805242 | 11 | 0 | 11 |
| PHACTR2 | ABLIM1 | 0.80501 | 11 | 0 | 11 |
For details and further investigation, click here
