| Full name: APOBEC1 complementation factor | Alias Symbol: ACF|ASP|ACF64|ACF65|APOBEC1CF | ||
| Type: protein-coding gene | Cytoband: 10q11.23 | ||
| Entrez ID: 29974 | HGNC ID: HGNC:24086 | Ensembl Gene: ENSG00000148584 | OMIM ID: 618199 |
| Drug and gene relationship at DGIdb | |||
Expression of A1CF:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | A1CF | 29974 | 220951_s_at | -0.3559 | 0.1802 | |
| GSE20347 | A1CF | 29974 | 220951_s_at | -0.1012 | 0.4330 | |
| GSE23400 | A1CF | 29974 | 220951_s_at | -0.2654 | 0.0000 | |
| GSE26886 | A1CF | 29974 | 220951_s_at | -0.3704 | 0.0077 | |
| GSE29001 | A1CF | 29974 | 220951_s_at | -0.5382 | 0.0072 | |
| GSE38129 | A1CF | 29974 | 220951_s_at | -0.2349 | 0.0084 | |
| GSE45670 | A1CF | 29974 | 220951_s_at | -0.0804 | 0.6086 | |
| GSE53622 | A1CF | 29974 | 155345 | 0.0454 | 0.7426 | |
| GSE53624 | A1CF | 29974 | 155345 | -0.0128 | 0.9479 | |
| GSE63941 | A1CF | 29974 | 220951_s_at | 0.3754 | 0.0218 | |
| GSE77861 | A1CF | 29974 | 220951_s_at | -0.2423 | 0.0566 | |
| GSE97050 | A1CF | 29974 | A_23_P104224 | -0.0566 | 0.8225 | |
| SRP133303 | A1CF | 29974 | RNAseq | 0.0610 | 0.7555 | |
| SRP159526 | A1CF | 29974 | RNAseq | -1.1251 | 0.0291 | |
| SRP193095 | A1CF | 29974 | RNAseq | -0.2070 | 0.4255 | |
| TCGA | A1CF | 29974 | RNAseq | -5.0621 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by A1CF expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of A1CF:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | A1CF | 29974 | 3 | 5 | 22 | |
| GSE20123 | A1CF | 29974 | 3 | 5 | 22 | |
| GSE43470 | A1CF | 29974 | 2 | 4 | 37 | |
| GSE46452 | A1CF | 29974 | 0 | 13 | 46 | |
| GSE47630 | A1CF | 29974 | 4 | 12 | 24 | |
| GSE54993 | A1CF | 29974 | 9 | 0 | 61 | |
| GSE54994 | A1CF | 29974 | 2 | 10 | 41 | |
| GSE60625 | A1CF | 29974 | 0 | 0 | 11 | |
| GSE74703 | A1CF | 29974 | 2 | 2 | 32 | |
| GSE74704 | A1CF | 29974 | 1 | 4 | 15 | |
| TCGA | A1CF | 29974 | 12 | 22 | 62 |
Total number of gains: 38; Total number of losses: 77; Total Number of normals: 373.
Somatic mutations of A1CF:
Generating mutation plots.
Highly correlated genes for A1CF:
Showing top 20/1132 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| A1CF | AZU1 | 0.727623 | 3 | 0 | 3 |
| A1CF | CACNG6 | 0.719986 | 4 | 0 | 4 |
| A1CF | KCNK9 | 0.717733 | 3 | 0 | 3 |
| A1CF | SKAP1 | 0.714471 | 3 | 0 | 3 |
| A1CF | RNF157 | 0.714106 | 4 | 0 | 4 |
| A1CF | FBF1 | 0.708496 | 3 | 0 | 3 |
| A1CF | BEAN1 | 0.706817 | 3 | 0 | 3 |
| A1CF | SYT13 | 0.706723 | 3 | 0 | 3 |
| A1CF | MAGEA8 | 0.704781 | 3 | 0 | 3 |
| A1CF | SVOPL | 0.704384 | 3 | 0 | 3 |
| A1CF | PPM1N | 0.70055 | 3 | 0 | 3 |
| A1CF | KLHL34 | 0.692514 | 3 | 0 | 3 |
| A1CF | OR4D2 | 0.690161 | 5 | 0 | 5 |
| A1CF | SLC16A11 | 0.686482 | 3 | 0 | 3 |
| A1CF | KIR2DS2 | 0.68578 | 6 | 0 | 6 |
| A1CF | AMHR2 | 0.678521 | 8 | 0 | 7 |
| A1CF | FMN1 | 0.678149 | 4 | 0 | 3 |
| A1CF | PCGEM1 | 0.677489 | 3 | 0 | 3 |
| A1CF | AP4B1 | 0.676839 | 3 | 0 | 3 |
| A1CF | GRTP1-AS1 | 0.676731 | 3 | 0 | 3 |
For details and further investigation, click here
