| Full name: src kinase associated phosphoprotein 1 | Alias Symbol: SKAP55 | ||
| Type: protein-coding gene | Cytoband: 17q21.32 | ||
| Entrez ID: 8631 | HGNC ID: HGNC:15605 | Ensembl Gene: ENSG00000141293 | OMIM ID: 604969 |
| Drug and gene relationship at DGIdb | |||
SKAP1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04015 | Rap1 signaling pathway |
Expression of SKAP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SKAP1 | 8631 | 205790_at | -0.0978 | 0.8462 | |
| GSE20347 | SKAP1 | 8631 | 205790_at | 0.0362 | 0.8664 | |
| GSE23400 | SKAP1 | 8631 | 205790_at | -0.1699 | 0.0004 | |
| GSE26886 | SKAP1 | 8631 | 205790_at | 0.3308 | 0.4082 | |
| GSE29001 | SKAP1 | 8631 | 205790_at | 0.0784 | 0.7470 | |
| GSE38129 | SKAP1 | 8631 | 205790_at | 0.1958 | 0.2890 | |
| GSE45670 | SKAP1 | 8631 | 205790_at | -0.2314 | 0.3104 | |
| GSE53622 | SKAP1 | 8631 | 65091 | -0.0494 | 0.4895 | |
| GSE53624 | SKAP1 | 8631 | 65091 | -0.1528 | 0.0833 | |
| GSE63941 | SKAP1 | 8631 | 205790_at | 0.3218 | 0.4512 | |
| GSE77861 | SKAP1 | 8631 | 205790_at | -0.0861 | 0.6207 | |
| GSE97050 | SKAP1 | 8631 | A_23_P100730 | 0.3927 | 0.2104 | |
| SRP064894 | SKAP1 | 8631 | RNAseq | 0.0279 | 0.9452 | |
| SRP133303 | SKAP1 | 8631 | RNAseq | -0.5815 | 0.0771 | |
| SRP159526 | SKAP1 | 8631 | RNAseq | -0.2358 | 0.7562 | |
| SRP219564 | SKAP1 | 8631 | RNAseq | 0.6781 | 0.1201 | |
| TCGA | SKAP1 | 8631 | RNAseq | 0.1489 | 0.6536 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SKAP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SKAP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SKAP1 | 8631 | 5 | 2 | 23 | |
| GSE20123 | SKAP1 | 8631 | 5 | 2 | 23 | |
| GSE43470 | SKAP1 | 8631 | 3 | 2 | 38 | |
| GSE46452 | SKAP1 | 8631 | 32 | 0 | 27 | |
| GSE47630 | SKAP1 | 8631 | 9 | 0 | 31 | |
| GSE54993 | SKAP1 | 8631 | 2 | 4 | 64 | |
| GSE54994 | SKAP1 | 8631 | 11 | 5 | 37 | |
| GSE60625 | SKAP1 | 8631 | 4 | 0 | 7 | |
| GSE74703 | SKAP1 | 8631 | 3 | 1 | 32 | |
| GSE74704 | SKAP1 | 8631 | 4 | 1 | 15 | |
| TCGA | SKAP1 | 8631 | 27 | 6 | 63 |
Total number of gains: 105; Total number of losses: 23; Total Number of normals: 360.
Somatic mutations of SKAP1:
Generating mutation plots.
Highly correlated genes for SKAP1:
Showing top 20/171 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SKAP1 | CTSE | 0.770862 | 3 | 0 | 3 |
| SKAP1 | PRRG3 | 0.759945 | 3 | 0 | 3 |
| SKAP1 | ORM1 | 0.739025 | 3 | 0 | 3 |
| SKAP1 | IL9R | 0.72673 | 3 | 0 | 3 |
| SKAP1 | SEC14L3 | 0.71855 | 3 | 0 | 3 |
| SKAP1 | A1CF | 0.714471 | 3 | 0 | 3 |
| SKAP1 | MCF2L | 0.70172 | 4 | 0 | 3 |
| SKAP1 | LRTM1 | 0.700922 | 3 | 0 | 3 |
| SKAP1 | RENBP | 0.692102 | 3 | 0 | 3 |
| SKAP1 | OTOF | 0.683515 | 3 | 0 | 3 |
| SKAP1 | GIPR | 0.679609 | 3 | 0 | 3 |
| SKAP1 | AGRP | 0.677467 | 3 | 0 | 3 |
| SKAP1 | CDH10 | 0.677124 | 4 | 0 | 3 |
| SKAP1 | KCNAB3 | 0.676287 | 5 | 0 | 5 |
| SKAP1 | ZNF341 | 0.671855 | 3 | 0 | 3 |
| SKAP1 | KLHL35 | 0.671432 | 3 | 0 | 3 |
| SKAP1 | ZMYND12 | 0.670916 | 3 | 0 | 3 |
| SKAP1 | GZMM | 0.668749 | 5 | 0 | 5 |
| SKAP1 | SLC1A7 | 0.66465 | 3 | 0 | 3 |
| SKAP1 | GDPD5 | 0.661835 | 4 | 0 | 3 |
For details and further investigation, click here
