| Full name: adaptor related protein complex 4 subunit beta 1 | Alias Symbol: BETA-4 | ||
| Type: protein-coding gene | Cytoband: 1p13.2 | ||
| Entrez ID: 10717 | HGNC ID: HGNC:572 | Ensembl Gene: ENSG00000134262 | OMIM ID: 607245 |
| Drug and gene relationship at DGIdb | |||
Expression of AP4B1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AP4B1 | 10717 | 231714_s_at | -0.3443 | 0.2571 | |
| GSE26886 | AP4B1 | 10717 | 231714_s_at | -1.4668 | 0.0000 | |
| GSE45670 | AP4B1 | 10717 | 231714_s_at | -0.5182 | 0.0135 | |
| GSE53622 | AP4B1 | 10717 | 39353 | -0.9652 | 0.0000 | |
| GSE53624 | AP4B1 | 10717 | 39353 | -1.0752 | 0.0000 | |
| GSE63941 | AP4B1 | 10717 | 231714_s_at | -0.1553 | 0.7727 | |
| GSE77861 | AP4B1 | 10717 | 231714_s_at | -1.0757 | 0.0009 | |
| GSE97050 | AP4B1 | 10717 | A_33_P3261973 | 0.1323 | 0.7686 | |
| SRP007169 | AP4B1 | 10717 | RNAseq | -2.7408 | 0.0000 | |
| SRP008496 | AP4B1 | 10717 | RNAseq | -2.8224 | 0.0000 | |
| SRP064894 | AP4B1 | 10717 | RNAseq | -1.0777 | 0.0000 | |
| SRP133303 | AP4B1 | 10717 | RNAseq | -0.9476 | 0.0000 | |
| SRP159526 | AP4B1 | 10717 | RNAseq | -1.1506 | 0.0104 | |
| SRP193095 | AP4B1 | 10717 | RNAseq | -1.1356 | 0.0000 | |
| SRP219564 | AP4B1 | 10717 | RNAseq | -0.6799 | 0.1144 | |
| TCGA | AP4B1 | 10717 | RNAseq | -0.1844 | 0.0034 |
Upregulated datasets: 0; Downregulated datasets: 8.
Survival by AP4B1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AP4B1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AP4B1 | 10717 | 0 | 9 | 21 | |
| GSE20123 | AP4B1 | 10717 | 0 | 9 | 21 | |
| GSE43470 | AP4B1 | 10717 | 0 | 8 | 35 | |
| GSE46452 | AP4B1 | 10717 | 2 | 1 | 56 | |
| GSE47630 | AP4B1 | 10717 | 9 | 5 | 26 | |
| GSE54993 | AP4B1 | 10717 | 0 | 1 | 69 | |
| GSE54994 | AP4B1 | 10717 | 7 | 3 | 43 | |
| GSE60625 | AP4B1 | 10717 | 0 | 0 | 11 | |
| GSE74703 | AP4B1 | 10717 | 0 | 7 | 29 | |
| GSE74704 | AP4B1 | 10717 | 0 | 5 | 15 | |
| TCGA | AP4B1 | 10717 | 11 | 30 | 55 |
Total number of gains: 29; Total number of losses: 78; Total Number of normals: 381.
Somatic mutations of AP4B1:
Generating mutation plots.
Highly correlated genes for AP4B1:
Showing top 20/611 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AP4B1 | NICN1 | 0.759124 | 3 | 0 | 3 |
| AP4B1 | KLB | 0.74032 | 6 | 0 | 6 |
| AP4B1 | ENTPD5 | 0.738679 | 6 | 0 | 6 |
| AP4B1 | MAGI3 | 0.735727 | 6 | 0 | 5 |
| AP4B1 | CCDC157 | 0.730885 | 3 | 0 | 3 |
| AP4B1 | UBL3 | 0.724982 | 6 | 0 | 6 |
| AP4B1 | PHACTR4 | 0.722817 | 6 | 0 | 6 |
| AP4B1 | AGFG2 | 0.718912 | 6 | 0 | 6 |
| AP4B1 | FAM3D | 0.718261 | 6 | 0 | 6 |
| AP4B1 | UPRT | 0.714131 | 6 | 0 | 6 |
| AP4B1 | IL18 | 0.712405 | 6 | 0 | 6 |
| AP4B1 | TAX1BP1 | 0.710992 | 5 | 0 | 5 |
| AP4B1 | RANBP9 | 0.709765 | 6 | 0 | 6 |
| AP4B1 | RIPK4 | 0.707359 | 3 | 0 | 3 |
| AP4B1 | FAM214A | 0.704487 | 6 | 0 | 6 |
| AP4B1 | SH3BGRL2 | 0.703314 | 6 | 0 | 6 |
| AP4B1 | SPNS2 | 0.703284 | 4 | 0 | 4 |
| AP4B1 | YOD1 | 0.702461 | 5 | 0 | 5 |
| AP4B1 | WWC1 | 0.701025 | 5 | 0 | 5 |
| AP4B1 | CCT6B | 0.700603 | 3 | 0 | 3 |
For details and further investigation, click here
