Full name: adenylate cyclase 5	Alias Symbol: AC5
Type: protein-coding gene	Cytoband: 3q21.1
Entrez ID: 111	HGNC ID: HGNC:236	Ensembl Gene: ENSG00000173175	OMIM ID: 600293
Drug and gene relationship at DGIdb

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ADCY5 involved pathways:

KEGG pathway	Description	View
hsa04015	Rap1 signaling pathway	View
hsa04022	cGMP-PKG signaling pathway	View
hsa04024	cAMP signaling pathway	View
hsa04062	Chemokine signaling pathway	View
hsa04072	Phospholipase D signaling pathway	View
hsa04114	Oocyte meiosis	View
hsa04211	Longevity regulating pathway - mammal	View
hsa04213	Longevity regulating pathway - multiple species	View
hsa04261	Adrenergic signaling in cardiomyocytes	View
hsa04270	Vascular smooth muscle contraction	View
hsa04540	Gap junction	View
hsa04611	Platelet activation	View
hsa04713	Circadian entrainment	View
hsa04723	Retrograde endocannabinoid signaling	View
hsa04724	Glutamatergic synapse	View
hsa04725	Cholinergic synapse	View
hsa04726	Serotonergic synapse	View
hsa04727	GABAergic synapse	View
hsa04728	Dopaminergic synapse	View
hsa04750	Inflammatory mediator regulation of TRP channels	View
hsa04911	Insulin secretion	View
hsa04912	GnRH signaling pathway	View
hsa04913	Ovarian steroidogenesis	View
hsa04914	Progesterone-mediated oocyte maturation	View
hsa04915	Estrogen signaling pathway	View
hsa04916	Melanogenesis	View
hsa04918	Thyroid hormone synthesis	View
hsa04921	Oxytocin signaling pathway	View
hsa04923	Regulation of lipolysis in adipocytes	View
hsa04924	Renin secretion	View
hsa04925	Aldosterone synthesis and secretion	View
hsa04970	Salivary secretion	View
hsa04971	Gastric acid secretion	View
hsa04972	Pancreatic secretion	View
hsa04976	Bile secretion	View
hsa05012	Parkinson's disease	View
hsa05030	Cocaine addiction	View
hsa05031	Amphetamine addiction	View
hsa05032	Morphine addiction	View
hsa05034	Alcoholism	View
hsa05166	HTLV-I infection	View

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Expression of ADCY5:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	ADCY5	111	228182_at	-1.0879	0.2189	Show
GSE26886	ADCY5	111	242891_at	0.1913	0.0985	Show
GSE45670	ADCY5	111	228182_at	-0.5987	0.0000	Show
GSE53622	ADCY5	111	4110	-1.9613	0.0000	Show
GSE53624	ADCY5	111	4110	-1.1246	0.0000	Show
GSE63941	ADCY5	111	242891_at	-0.3559	0.0064	Show
GSE77861	ADCY5	111	242891_at	-0.0140	0.8926	Show
GSE97050	ADCY5	111	A_23_P136623	-0.8996	0.2243	Show
SRP007169	ADCY5	111	RNAseq	0.1578	0.8183	Show
SRP064894	ADCY5	111	RNAseq	-1.0889	0.0091	Show
SRP133303	ADCY5	111	RNAseq	-2.5059	0.0000	Show
SRP159526	ADCY5	111	RNAseq	-1.0758	0.0345	Show
SRP219564	ADCY5	111	RNAseq	-0.6618	0.5770	Show
TCGA	ADCY5	111	RNAseq	-1.1819	0.0012	Show

Upregulated datasets: 0; Downregulated datasets: 6.  Download Data

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Survival by ADCY5 expression:

 

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Copy number change of ADCY5:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	ADCY5	111	17	0	13	Show
GSE20123	ADCY5	111	17	0	13	Show
GSE43470	ADCY5	111	20	0	23	Show
GSE46452	ADCY5	111	14	5	40	Show
GSE47630	ADCY5	111	17	4	19	Show
GSE54993	ADCY5	111	2	7	61	Show
GSE54994	ADCY5	111	30	4	19	Show
GSE60625	ADCY5	111	0	6	5	Show
GSE74703	ADCY5	111	16	0	20	Show
GSE74704	ADCY5	111	13	0	7	Show
TCGA	ADCY5	111	54	6	36	Show

Total number of gains: 200; Total number of losses: 32; Total Number of normals: 256.  Download Data

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Somatic mutations of ADCY5:

 

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Highly correlated genes for ADCY5:

 

Showing top 20/662 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
ADCY5	PYGM	0.841694	5	0	5
ADCY5	MYOCD	0.823849	6	0	6
ADCY5	PGM5	0.821218	5	0	5
ADCY5	ATP1A2	0.803721	5	0	5
ADCY5	ZBTB47	0.800471	4	0	4
ADCY5	TCEAL2	0.797821	5	0	5
ADCY5	FXYD1	0.797095	3	0	3
ADCY5	DES	0.793397	5	0	5
ADCY5	CHRDL1	0.791696	4	0	4
ADCY5	RBFOX3	0.780614	3	0	3
ADCY5	FRRS1L	0.779216	3	0	3
ADCY5	UBXN10-AS1	0.779167	3	0	3
ADCY5	TACR2	0.778459	6	0	6
ADCY5	ACTBL2	0.76939	3	0	3
ADCY5	ANKS1B	0.763042	4	0	4
ADCY5	PRR26	0.760852	4	0	4
ADCY5	GPR20	0.76013	3	0	3
ADCY5	PDE1C	0.759866	6	0	6
ADCY5	ADAMTS9-AS2	0.753163	5	0	5
ADCY5	XKR4	0.752544	5	0	5

For details and further investigation, click here