ADCY5

 

Full name: adenylate cyclase 5 Alias Symbol: AC5
Type: protein-coding gene Cytoband: 3q21.1
Entrez ID: 111 HGNC ID: HGNC:236 Ensembl Gene: ENSG00000173175 OMIM ID: 600293
Drug and gene relationship at DGIdb

 

ADCY5 involved pathways:

KEGG pathway Description View
hsa04015Rap1 signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04062Chemokine signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04114Oocyte meiosis
hsa04211Longevity regulating pathway - mammal
hsa04213Longevity regulating pathway - multiple species
hsa04261Adrenergic signaling in cardiomyocytes
hsa04270Vascular smooth muscle contraction
hsa04540Gap junction
hsa04611Platelet activation
hsa04713Circadian entrainment
hsa04723Retrograde endocannabinoid signaling
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04726Serotonergic synapse
hsa04727GABAergic synapse
hsa04728Dopaminergic synapse
hsa04750Inflammatory mediator regulation of TRP channels
hsa04911Insulin secretion
hsa04912GnRH signaling pathway
hsa04913Ovarian steroidogenesis
hsa04914Progesterone-mediated oocyte maturation
hsa04915Estrogen signaling pathway
hsa04916Melanogenesis
hsa04918Thyroid hormone synthesis
hsa04921Oxytocin signaling pathway
hsa04923Regulation of lipolysis in adipocytes
hsa04924Renin secretion
hsa04925Aldosterone synthesis and secretion
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa04976Bile secretion
hsa05012Parkinson's disease
hsa05030Cocaine addiction
hsa05031Amphetamine addiction
hsa05032Morphine addiction
hsa05034Alcoholism
hsa05166HTLV-I infection

 

Expression of ADCY5:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ADCY5 111 228182_at -1.0879 0.2189
GSE26886 ADCY5 111 242891_at 0.1913 0.0985
GSE45670 ADCY5 111 228182_at -0.5987 0.0000
GSE53622 ADCY5 111 4110 -1.9613 0.0000
GSE53624 ADCY5 111 4110 -1.1246 0.0000
GSE63941 ADCY5 111 242891_at -0.3559 0.0064
GSE77861 ADCY5 111 242891_at -0.0140 0.8926
GSE97050 ADCY5 111 A_23_P136623 -0.8996 0.2243
SRP007169 ADCY5 111 RNAseq 0.1578 0.8183
SRP064894 ADCY5 111 RNAseq -1.0889 0.0091
SRP133303 ADCY5 111 RNAseq -2.5059 0.0000
SRP159526 ADCY5 111 RNAseq -1.0758 0.0345
SRP219564 ADCY5 111 RNAseq -0.6618 0.5770
TCGA ADCY5 111 RNAseq -1.1819 0.0012

Upregulated datasets: 0; Downregulated datasets: 6.  


 

Survival by ADCY5 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  


Copy number change of ADCY5:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ADCY5 111 17 0 13
GSE20123 ADCY5 111 17 0 13
GSE43470 ADCY5 111 20 0 23
GSE46452 ADCY5 111 14 5 40
GSE47630 ADCY5 111 17 4 19
GSE54993 ADCY5 111 2 7 61
GSE54994 ADCY5 111 30 4 19
GSE60625 ADCY5 111 0 6 5
GSE74703 ADCY5 111 16 0 20
GSE74704 ADCY5 111 13 0 7
TCGA ADCY5 111 54 6 36

Total number of gains: 200; Total number of losses: 32; Total Number of normals: 256.  


 

Somatic mutations of ADCY5:

 

Generating mutation plots.

 

Highly correlated genes for ADCY5:

 

Showing top 20/662 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ADCY5PYGM0.841694505
ADCY5MYOCD0.823849606
ADCY5PGM50.821218505
ADCY5ATP1A20.803721505
ADCY5ZBTB470.800471404
ADCY5TCEAL20.797821505
ADCY5FXYD10.797095303
ADCY5DES0.793397505
ADCY5CHRDL10.791696404
ADCY5RBFOX30.780614303
ADCY5FRRS1L0.779216303
ADCY5UBXN10-AS10.779167303
ADCY5TACR20.778459606
ADCY5ACTBL20.76939303
ADCY5ANKS1B0.763042404
ADCY5PRR260.760852404
ADCY5GPR200.76013303
ADCY5PDE1C0.759866606
ADCY5ADAMTS9-AS20.753163505
ADCY5XKR40.752544505

For details and further investigation, click here