| Full name: tachykinin receptor 2 | Alias Symbol: SKR|NK2R | ||
| Type: protein-coding gene | Cytoband: 10q22.1 | ||
| Entrez ID: 6865 | HGNC ID: HGNC:11527 | Ensembl Gene: ENSG00000075073 | OMIM ID: 162321 |
| Drug and gene relationship at DGIdb | |||
TACR2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway |
Expression of TACR2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TACR2 | 6865 | 214348_at | -0.9382 | 0.3622 | |
| GSE20347 | TACR2 | 6865 | 214348_at | -0.1072 | 0.4789 | |
| GSE23400 | TACR2 | 6865 | 214348_at | -0.4217 | 0.0000 | |
| GSE26886 | TACR2 | 6865 | 214348_at | 0.2225 | 0.1460 | |
| GSE29001 | TACR2 | 6865 | 214348_at | -0.1863 | 0.3547 | |
| GSE38129 | TACR2 | 6865 | 214348_at | -0.7944 | 0.0049 | |
| GSE45670 | TACR2 | 6865 | 214348_at | -0.5609 | 0.0001 | |
| GSE53622 | TACR2 | 6865 | 28883 | -1.3149 | 0.0000 | |
| GSE53624 | TACR2 | 6865 | 28883 | -1.1249 | 0.0000 | |
| GSE63941 | TACR2 | 6865 | 214348_at | 0.2478 | 0.1948 | |
| GSE77861 | TACR2 | 6865 | 214348_at | -0.0069 | 0.9684 | |
| GSE97050 | TACR2 | 6865 | A_23_P24135 | -0.9798 | 0.2694 | |
| SRP064894 | TACR2 | 6865 | RNAseq | -1.2783 | 0.0072 | |
| SRP133303 | TACR2 | 6865 | RNAseq | -0.3280 | 0.3546 | |
| SRP159526 | TACR2 | 6865 | RNAseq | -2.6121 | 0.0000 | |
| SRP193095 | TACR2 | 6865 | RNAseq | 0.0845 | 0.6422 | |
| SRP219564 | TACR2 | 6865 | RNAseq | 0.6049 | 0.5864 | |
| TCGA | TACR2 | 6865 | RNAseq | -1.0401 | 0.0031 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by TACR2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TACR2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TACR2 | 6865 | 3 | 4 | 23 | |
| GSE20123 | TACR2 | 6865 | 3 | 3 | 24 | |
| GSE43470 | TACR2 | 6865 | 1 | 7 | 35 | |
| GSE46452 | TACR2 | 6865 | 0 | 11 | 48 | |
| GSE47630 | TACR2 | 6865 | 2 | 14 | 24 | |
| GSE54993 | TACR2 | 6865 | 7 | 0 | 63 | |
| GSE54994 | TACR2 | 6865 | 2 | 12 | 39 | |
| GSE60625 | TACR2 | 6865 | 0 | 0 | 11 | |
| GSE74703 | TACR2 | 6865 | 1 | 4 | 31 | |
| GSE74704 | TACR2 | 6865 | 1 | 1 | 18 | |
| TCGA | TACR2 | 6865 | 9 | 23 | 64 |
Total number of gains: 29; Total number of losses: 79; Total Number of normals: 380.
Somatic mutations of TACR2:
Generating mutation plots.
Highly correlated genes for TACR2:
Showing top 20/714 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TACR2 | CYP21A2 | 0.815188 | 3 | 0 | 3 |
| TACR2 | ADCY5 | 0.778459 | 6 | 0 | 6 |
| TACR2 | CORO6 | 0.775316 | 3 | 0 | 3 |
| TACR2 | FRRS1L | 0.767504 | 6 | 0 | 6 |
| TACR2 | PPP1R12B | 0.764481 | 9 | 0 | 9 |
| TACR2 | PLA2G5 | 0.753625 | 9 | 0 | 8 |
| TACR2 | SMTN | 0.75313 | 8 | 0 | 8 |
| TACR2 | XKR4 | 0.752452 | 5 | 0 | 5 |
| TACR2 | CLEC3B | 0.751324 | 3 | 0 | 3 |
| TACR2 | PRR26 | 0.75069 | 5 | 0 | 5 |
| TACR2 | PYGM | 0.7497 | 11 | 0 | 9 |
| TACR2 | ITGA7 | 0.748883 | 10 | 0 | 9 |
| TACR2 | MYOC | 0.742531 | 9 | 0 | 9 |
| TACR2 | SGCA | 0.742477 | 11 | 0 | 9 |
| TACR2 | MYOM1 | 0.740811 | 11 | 0 | 9 |
| TACR2 | SLC35F1 | 0.736241 | 4 | 0 | 3 |
| TACR2 | MAMDC2 | 0.736182 | 5 | 0 | 5 |
| TACR2 | HPSE2 | 0.735233 | 10 | 0 | 8 |
| TACR2 | TCEAL2 | 0.734982 | 9 | 0 | 8 |
| TACR2 | VMAC | 0.731071 | 3 | 0 | 3 |
For details and further investigation, click here
