ATP1A2

 

Full name: ATPase Na+/K+ transporting subunit alpha 2 Alias Symbol: FHM2
Type: protein-coding gene Cytoband: 1q23.2
Entrez ID: 477 HGNC ID: HGNC:800 Ensembl Gene: ENSG00000018625 OMIM ID: 182340
Drug and gene relationship at DGIdb

 

ATP1A2 involved pathways:

KEGG pathway Description View
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04261Adrenergic signaling in cardiomyocytes
hsa04919Thyroid hormone signaling pathway
hsa04960Aldosterone-regulated sodium reabsorption
hsa04961Endocrine and other factor-regulated calcium reabsorption

 

Expression of ATP1A2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ATP1A2 477 203296_s_at -3.5277 0.0616
GSE20347 ATP1A2 477 203296_s_at -1.0447 0.0096
GSE23400 ATP1A2 477 203296_s_at -1.0799 0.0000
GSE26886 ATP1A2 477 203295_s_at -0.2435 0.0830
GSE29001 ATP1A2 477 203296_s_at -1.1935 0.0003
GSE38129 ATP1A2 477 203296_s_at -2.0123 0.0001
GSE45670 ATP1A2 477 203296_s_at -4.1893 0.0000
GSE53622 ATP1A2 477 57421 -4.2809 0.0000
GSE53624 ATP1A2 477 162023 -4.4787 0.0000
GSE63941 ATP1A2 477 203295_s_at 0.1606 0.2766
GSE77861 ATP1A2 477 203295_s_at -0.1121 0.2910
GSE97050 ATP1A2 477 A_33_P3359771 -2.3552 0.0631
SRP064894 ATP1A2 477 RNAseq -2.0259 0.0003
SRP133303 ATP1A2 477 RNAseq -2.2393 0.0280
SRP159526 ATP1A2 477 RNAseq -2.9843 0.0000
SRP219564 ATP1A2 477 RNAseq -1.0253 0.3999
TCGA ATP1A2 477 RNAseq -1.7605 0.0007

Upregulated datasets: 0; Downregulated datasets: 11.  

 

Survival by ATP1A2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ATP1A2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ATP1A2 477 10 0 20
GSE20123 ATP1A2 477 10 0 20
GSE43470 ATP1A2 477 7 2 34
GSE46452 ATP1A2 477 2 1 56
GSE47630 ATP1A2 477 15 0 25
GSE54993 ATP1A2 477 0 5 65
GSE54994 ATP1A2 477 16 0 37
GSE60625 ATP1A2 477 0 0 11
GSE74703 ATP1A2 477 7 2 27
GSE74704 ATP1A2 477 4 0 16
TCGA ATP1A2 477 44 3 49

Total number of gains: 115; Total number of losses: 13; Total Number of normals: 360.  

 

Somatic mutations of ATP1A2:

 

Generating mutation plots.

 

Highly correlated genes for ATP1A2:

 

Showing top 20/1129 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ATP1A2PPP1R12B0.896983909
ATP1A2PDZRN40.872563909
ATP1A2CYP21A20.867025303
ATP1A2CLEC3B0.863577303
ATP1A2SYNPO20.849579605
ATP1A2PLN0.84939610010
ATP1A2ASB50.846662505
ATP1A2PCP40.8403310010
ATP1A2HMHB10.830712303
ATP1A2RBFOX30.830336303
ATP1A2TNS10.828449909
ATP1A2PTCHD10.824138505
ATP1A2ABCA80.8214431009
ATP1A2XKR40.816525605
ATP1A2SH3BGR0.815017808
ATP1A2PGM50.8125971009
ATP1A2OGN0.80972410010
ATP1A2CASQ20.80890212011
ATP1A2RGS7BP0.808336505
ATP1A2ADAMTS9-AS20.805567505

For details and further investigation, click here