| Full name: adducin 2 | Alias Symbol: ADDB | ||
| Type: protein-coding gene | Cytoband: 2p13.3 | ||
| Entrez ID: 119 | HGNC ID: HGNC:244 | Ensembl Gene: ENSG00000075340 | OMIM ID: 102681 |
| Drug and gene relationship at DGIdb | |||
Expression of ADD2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADD2 | 119 | 206807_s_at | 0.0018 | 0.9966 | |
| GSE20347 | ADD2 | 119 | 206807_s_at | -0.0227 | 0.8568 | |
| GSE23400 | ADD2 | 119 | 206807_s_at | -0.1116 | 0.0024 | |
| GSE26886 | ADD2 | 119 | 206807_s_at | 0.0994 | 0.4447 | |
| GSE29001 | ADD2 | 119 | 213484_at | 0.8446 | 0.0637 | |
| GSE38129 | ADD2 | 119 | 206807_s_at | -0.0848 | 0.5132 | |
| GSE45670 | ADD2 | 119 | 206807_s_at | -0.0056 | 0.9686 | |
| GSE53622 | ADD2 | 119 | 10239 | 0.5514 | 0.0017 | |
| GSE53624 | ADD2 | 119 | 10239 | 0.4842 | 0.0001 | |
| GSE63941 | ADD2 | 119 | 213484_at | 1.8066 | 0.1536 | |
| GSE77861 | ADD2 | 119 | 213484_at | 0.5044 | 0.1540 | |
| GSE97050 | ADD2 | 119 | A_33_P3241782 | 0.1317 | 0.7400 | |
| SRP007169 | ADD2 | 119 | RNAseq | 6.4741 | 0.0002 | |
| SRP064894 | ADD2 | 119 | RNAseq | 0.2983 | 0.4550 | |
| SRP133303 | ADD2 | 119 | RNAseq | 0.1591 | 0.6135 | |
| SRP159526 | ADD2 | 119 | RNAseq | 3.7733 | 0.0000 | |
| SRP193095 | ADD2 | 119 | RNAseq | 2.1128 | 0.0000 | |
| SRP219564 | ADD2 | 119 | RNAseq | 0.1115 | 0.8600 | |
| TCGA | ADD2 | 119 | RNAseq | 0.7820 | 0.0364 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by ADD2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ADD2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADD2 | 119 | 11 | 1 | 18 | |
| GSE20123 | ADD2 | 119 | 11 | 1 | 18 | |
| GSE43470 | ADD2 | 119 | 3 | 0 | 40 | |
| GSE46452 | ADD2 | 119 | 2 | 3 | 54 | |
| GSE47630 | ADD2 | 119 | 7 | 0 | 33 | |
| GSE54993 | ADD2 | 119 | 0 | 6 | 64 | |
| GSE54994 | ADD2 | 119 | 11 | 0 | 42 | |
| GSE60625 | ADD2 | 119 | 0 | 3 | 8 | |
| GSE74703 | ADD2 | 119 | 3 | 0 | 33 | |
| GSE74704 | ADD2 | 119 | 9 | 0 | 11 | |
| TCGA | ADD2 | 119 | 37 | 2 | 57 |
Total number of gains: 94; Total number of losses: 16; Total Number of normals: 378.
Somatic mutations of ADD2:
Generating mutation plots.
Highly correlated genes for ADD2:
Showing top 20/368 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADD2 | PKD2L1 | 0.773124 | 3 | 0 | 3 |
| ADD2 | NPTX2 | 0.760191 | 3 | 0 | 3 |
| ADD2 | LYG1 | 0.746022 | 3 | 0 | 3 |
| ADD2 | TRAPPC9 | 0.742758 | 3 | 0 | 3 |
| ADD2 | C11orf94 | 0.719076 | 4 | 0 | 3 |
| ADD2 | C20orf144 | 0.719005 | 3 | 0 | 3 |
| ADD2 | IFNA17 | 0.706347 | 3 | 0 | 3 |
| ADD2 | SNTG2 | 0.704101 | 3 | 0 | 3 |
| ADD2 | HOXD9 | 0.699541 | 3 | 0 | 3 |
| ADD2 | USH1C | 0.696509 | 5 | 0 | 4 |
| ADD2 | TUBB2B | 0.693902 | 3 | 0 | 3 |
| ADD2 | TMEM151B | 0.686031 | 4 | 0 | 3 |
| ADD2 | ARVCF | 0.683738 | 5 | 0 | 4 |
| ADD2 | CCZ1 | 0.682456 | 4 | 0 | 4 |
| ADD2 | GPR62 | 0.680675 | 4 | 0 | 3 |
| ADD2 | RNF17 | 0.677933 | 3 | 0 | 3 |
| ADD2 | C10orf95 | 0.676785 | 4 | 0 | 3 |
| ADD2 | BTBD19 | 0.675297 | 3 | 0 | 3 |
| ADD2 | CCDC8 | 0.671036 | 4 | 0 | 3 |
| ADD2 | PRR34 | 0.669082 | 3 | 0 | 3 |
For details and further investigation, click here
