| Full name: polycystin 2 like 1, transient receptor potential cation channel | Alias Symbol: PCL|TRPP3 | ||
| Type: protein-coding gene | Cytoband: 10q24.31 | ||
| Entrez ID: 9033 | HGNC ID: HGNC:9011 | Ensembl Gene: ENSG00000107593 | OMIM ID: 604532 |
| Drug and gene relationship at DGIdb | |||
PKD2L1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04742 | Taste transduction |
Expression of PKD2L1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PKD2L1 | 9033 | 221061_at | -0.0629 | 0.7667 | |
| GSE20347 | PKD2L1 | 9033 | 221061_at | -0.1272 | 0.0679 | |
| GSE23400 | PKD2L1 | 9033 | 221061_at | -0.0796 | 0.0029 | |
| GSE26886 | PKD2L1 | 9033 | 221061_at | -0.0983 | 0.5685 | |
| GSE29001 | PKD2L1 | 9033 | 221061_at | -0.0452 | 0.7643 | |
| GSE38129 | PKD2L1 | 9033 | 221061_at | -0.1061 | 0.0632 | |
| GSE45670 | PKD2L1 | 9033 | 221061_at | 0.0573 | 0.5089 | |
| GSE53622 | PKD2L1 | 9033 | 83960 | -0.7268 | 0.0000 | |
| GSE53624 | PKD2L1 | 9033 | 83960 | -0.5865 | 0.0000 | |
| GSE63941 | PKD2L1 | 9033 | 221061_at | -0.1681 | 0.2922 | |
| GSE77861 | PKD2L1 | 9033 | 221061_at | -0.1663 | 0.2459 | |
| GSE97050 | PKD2L1 | 9033 | A_33_P3289034 | -0.4601 | 0.1556 | |
| TCGA | PKD2L1 | 9033 | RNAseq | 2.3192 | 0.0097 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PKD2L1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PKD2L1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PKD2L1 | 9033 | 1 | 8 | 21 | |
| GSE20123 | PKD2L1 | 9033 | 1 | 7 | 22 | |
| GSE43470 | PKD2L1 | 9033 | 0 | 7 | 36 | |
| GSE46452 | PKD2L1 | 9033 | 0 | 11 | 48 | |
| GSE47630 | PKD2L1 | 9033 | 2 | 14 | 24 | |
| GSE54993 | PKD2L1 | 9033 | 8 | 0 | 62 | |
| GSE54994 | PKD2L1 | 9033 | 1 | 12 | 40 | |
| GSE60625 | PKD2L1 | 9033 | 0 | 0 | 11 | |
| GSE74703 | PKD2L1 | 9033 | 0 | 5 | 31 | |
| GSE74704 | PKD2L1 | 9033 | 0 | 4 | 16 | |
| TCGA | PKD2L1 | 9033 | 5 | 28 | 63 |
Total number of gains: 18; Total number of losses: 96; Total Number of normals: 374.
Somatic mutations of PKD2L1:
Generating mutation plots.
Highly correlated genes for PKD2L1:
Showing top 20/1151 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PKD2L1 | OR10G8 | 0.872911 | 3 | 0 | 3 |
| PKD2L1 | KRTAP20-1 | 0.862129 | 3 | 0 | 3 |
| PKD2L1 | CATSPER3 | 0.854096 | 3 | 0 | 3 |
| PKD2L1 | GDF7 | 0.82886 | 3 | 0 | 3 |
| PKD2L1 | OR2Z1 | 0.824021 | 3 | 0 | 3 |
| PKD2L1 | TPRX1 | 0.800557 | 3 | 0 | 3 |
| PKD2L1 | CLDN24 | 0.797246 | 3 | 0 | 3 |
| PKD2L1 | TEN1 | 0.793613 | 3 | 0 | 3 |
| PKD2L1 | MFSD2B | 0.784917 | 4 | 0 | 4 |
| PKD2L1 | CD164L2 | 0.778129 | 3 | 0 | 3 |
| PKD2L1 | GALNT9 | 0.774665 | 5 | 0 | 5 |
| PKD2L1 | ADD2 | 0.773124 | 3 | 0 | 3 |
| PKD2L1 | KRTAP4-1 | 0.7678 | 3 | 0 | 3 |
| PKD2L1 | ERN1 | 0.75924 | 3 | 0 | 3 |
| PKD2L1 | KRTAP6-1 | 0.758726 | 4 | 0 | 3 |
| PKD2L1 | OR13G1 | 0.754127 | 3 | 0 | 3 |
| PKD2L1 | ISLR2 | 0.752588 | 3 | 0 | 3 |
| PKD2L1 | FAM163B | 0.74966 | 3 | 0 | 3 |
| PKD2L1 | NT5C1A | 0.747126 | 4 | 0 | 4 |
| PKD2L1 | LACRT | 0.743601 | 4 | 0 | 4 |
For details and further investigation, click here
