| Full name: coiled-coil domain containing 8 | Alias Symbol: DKFZp564K0322|3M3|PPP1R20 | ||
| Type: protein-coding gene | Cytoband: 19q13.32 | ||
| Entrez ID: 83987 | HGNC ID: HGNC:25367 | Ensembl Gene: ENSG00000169515 | OMIM ID: 614145 |
| Drug and gene relationship at DGIdb | |||
Expression of CCDC8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CCDC8 | 83987 | 223495_at | -0.0417 | 0.9295 | |
| GSE26886 | CCDC8 | 83987 | 223495_at | 1.1916 | 0.0007 | |
| GSE45670 | CCDC8 | 83987 | 223495_at | -0.0948 | 0.8382 | |
| GSE53622 | CCDC8 | 83987 | 36375 | -0.6087 | 0.0000 | |
| GSE53624 | CCDC8 | 83987 | 36375 | -0.1666 | 0.1315 | |
| GSE63941 | CCDC8 | 83987 | 223495_at | 0.0408 | 0.9639 | |
| GSE77861 | CCDC8 | 83987 | 223495_at | 0.2758 | 0.2238 | |
| GSE97050 | CCDC8 | 83987 | A_23_P164958 | -0.5679 | 0.1163 | |
| SRP007169 | CCDC8 | 83987 | RNAseq | 4.8169 | 0.0001 | |
| SRP064894 | CCDC8 | 83987 | RNAseq | 1.9111 | 0.0000 | |
| SRP133303 | CCDC8 | 83987 | RNAseq | 1.1325 | 0.0010 | |
| SRP159526 | CCDC8 | 83987 | RNAseq | 2.8200 | 0.0021 | |
| SRP193095 | CCDC8 | 83987 | RNAseq | 1.7244 | 0.0000 | |
| SRP219564 | CCDC8 | 83987 | RNAseq | 1.3354 | 0.0462 | |
| TCGA | CCDC8 | 83987 | RNAseq | 0.3436 | 0.1476 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by CCDC8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CCDC8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CCDC8 | 83987 | 4 | 5 | 21 | |
| GSE20123 | CCDC8 | 83987 | 4 | 4 | 22 | |
| GSE43470 | CCDC8 | 83987 | 3 | 11 | 29 | |
| GSE46452 | CCDC8 | 83987 | 45 | 1 | 13 | |
| GSE47630 | CCDC8 | 83987 | 8 | 7 | 25 | |
| GSE54993 | CCDC8 | 83987 | 17 | 4 | 49 | |
| GSE54994 | CCDC8 | 83987 | 5 | 13 | 35 | |
| GSE60625 | CCDC8 | 83987 | 9 | 0 | 2 | |
| GSE74703 | CCDC8 | 83987 | 3 | 7 | 26 | |
| GSE74704 | CCDC8 | 83987 | 4 | 2 | 14 | |
| TCGA | CCDC8 | 83987 | 15 | 15 | 66 |
Total number of gains: 117; Total number of losses: 69; Total Number of normals: 302.
Somatic mutations of CCDC8:
Generating mutation plots.
Highly correlated genes for CCDC8:
Showing top 20/92 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CCDC8 | NPTX2 | 0.769792 | 3 | 0 | 3 |
| CCDC8 | TREM1 | 0.749666 | 3 | 0 | 3 |
| CCDC8 | ATP8A2 | 0.749244 | 3 | 0 | 3 |
| CCDC8 | ZNF526 | 0.736923 | 3 | 0 | 3 |
| CCDC8 | PALLD | 0.725983 | 3 | 0 | 3 |
| CCDC8 | DUSP9 | 0.725583 | 3 | 0 | 3 |
| CCDC8 | SPRED3 | 0.71771 | 3 | 0 | 3 |
| CCDC8 | ST8SIA1 | 0.711524 | 4 | 0 | 3 |
| CCDC8 | ALKBH5 | 0.70935 | 3 | 0 | 3 |
| CCDC8 | MAG | 0.698172 | 3 | 0 | 3 |
| CCDC8 | CITED1 | 0.697285 | 3 | 0 | 3 |
| CCDC8 | POLD1 | 0.691535 | 3 | 0 | 3 |
| CCDC8 | ANTXR1 | 0.685344 | 3 | 0 | 3 |
| CCDC8 | SNAP91 | 0.681718 | 3 | 0 | 3 |
| CCDC8 | MAMLD1 | 0.680165 | 3 | 0 | 3 |
| CCDC8 | BCL2L12 | 0.679849 | 3 | 0 | 3 |
| CCDC8 | ZNF446 | 0.673397 | 4 | 0 | 4 |
| CCDC8 | KCNN2 | 0.673176 | 3 | 0 | 3 |
| CCDC8 | IGFALS | 0.671816 | 3 | 0 | 3 |
| CCDC8 | ADD2 | 0.671036 | 4 | 0 | 3 |
For details and further investigation, click here
