| Full name: tubulin beta 2B class IIb | Alias Symbol: MGC8685|DKFZp566F223|bA506K6.1 | ||
| Type: protein-coding gene | Cytoband: 6p25.2 | ||
| Entrez ID: 347733 | HGNC ID: HGNC:30829 | Ensembl Gene: ENSG00000137285 | OMIM ID: 612850 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
TUBB2B involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05130 | Pathogenic Escherichia coli infection |
Expression of TUBB2B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TUBB2B | 347733 | 214023_x_at | -0.1407 | 0.8772 | |
| GSE20347 | TUBB2B | 347733 | 214023_x_at | 1.0242 | 0.0149 | |
| GSE23400 | TUBB2B | 347733 | 214023_x_at | 0.2742 | 0.0244 | |
| GSE26886 | TUBB2B | 347733 | 214023_x_at | 1.9040 | 0.0022 | |
| GSE29001 | TUBB2B | 347733 | 214023_x_at | 0.9826 | 0.2079 | |
| GSE38129 | TUBB2B | 347733 | 214023_x_at | 0.7789 | 0.1351 | |
| GSE45670 | TUBB2B | 347733 | 214023_x_at | 0.2580 | 0.7350 | |
| GSE53622 | TUBB2B | 347733 | 27802 | 1.0096 | 0.0000 | |
| GSE53624 | TUBB2B | 347733 | 39620 | 0.8323 | 0.0000 | |
| GSE63941 | TUBB2B | 347733 | 214023_x_at | 1.2316 | 0.3261 | |
| GSE77861 | TUBB2B | 347733 | 214023_x_at | 0.8571 | 0.1199 | |
| SRP064894 | TUBB2B | 347733 | RNAseq | -0.5218 | 0.1874 | |
| SRP133303 | TUBB2B | 347733 | RNAseq | 0.8279 | 0.1097 | |
| SRP159526 | TUBB2B | 347733 | RNAseq | 1.7388 | 0.0400 | |
| SRP219564 | TUBB2B | 347733 | RNAseq | 0.2527 | 0.7383 | |
| TCGA | TUBB2B | 347733 | RNAseq | -0.0314 | 0.9358 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by TUBB2B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TUBB2B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TUBB2B | 347733 | 4 | 5 | 21 | |
| GSE20123 | TUBB2B | 347733 | 4 | 5 | 21 | |
| GSE43470 | TUBB2B | 347733 | 8 | 2 | 33 | |
| GSE46452 | TUBB2B | 347733 | 1 | 10 | 48 | |
| GSE47630 | TUBB2B | 347733 | 7 | 8 | 25 | |
| GSE54993 | TUBB2B | 347733 | 1 | 1 | 68 | |
| GSE54994 | TUBB2B | 347733 | 10 | 3 | 40 | |
| GSE60625 | TUBB2B | 347733 | 0 | 1 | 10 | |
| GSE74703 | TUBB2B | 347733 | 7 | 2 | 27 | |
| GSE74704 | TUBB2B | 347733 | 2 | 2 | 16 | |
| TCGA | TUBB2B | 347733 | 17 | 30 | 49 |
Total number of gains: 61; Total number of losses: 69; Total Number of normals: 358.
Somatic mutations of TUBB2B:
Generating mutation plots.
Highly correlated genes for TUBB2B:
Showing top 20/520 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TUBB2B | TRMT112 | 0.765703 | 3 | 0 | 3 |
| TUBB2B | TRAM2-AS1 | 0.698056 | 3 | 0 | 3 |
| TUBB2B | ADD2 | 0.693902 | 3 | 0 | 3 |
| TUBB2B | PTK7 | 0.691199 | 4 | 0 | 3 |
| TUBB2B | CDC25B | 0.68703 | 3 | 0 | 3 |
| TUBB2B | TRIM45 | 0.685213 | 4 | 0 | 4 |
| TUBB2B | KLHL42 | 0.684717 | 3 | 0 | 3 |
| TUBB2B | FANCB | 0.682599 | 3 | 0 | 3 |
| TUBB2B | BSG | 0.679883 | 3 | 0 | 3 |
| TUBB2B | TMEM116 | 0.671305 | 3 | 0 | 3 |
| TUBB2B | GRIA2 | 0.666601 | 3 | 0 | 3 |
| TUBB2B | SLC52A1 | 0.664611 | 3 | 0 | 3 |
| TUBB2B | GPC4 | 0.662597 | 7 | 0 | 6 |
| TUBB2B | BMP1 | 0.660238 | 3 | 0 | 3 |
| TUBB2B | SENP3 | 0.659285 | 3 | 0 | 3 |
| TUBB2B | MRPL21 | 0.659194 | 3 | 0 | 3 |
| TUBB2B | RHBDD2 | 0.658431 | 4 | 0 | 4 |
| TUBB2B | PCDH19 | 0.656415 | 4 | 0 | 4 |
| TUBB2B | KIAA1549 | 0.655611 | 4 | 0 | 3 |
| TUBB2B | KDM1A | 0.654804 | 4 | 0 | 3 |
For details and further investigation, click here
