| Full name: alcohol dehydrogenase 5 (class III), chi polypeptide | Alias Symbol: ADH-3|ADHX|GSNOR | ||
| Type: protein-coding gene | Cytoband: 4q23 | ||
| Entrez ID: 128 | HGNC ID: HGNC:253 | Ensembl Gene: ENSG00000197894 | OMIM ID: 103710 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ADH5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADH5 | 128 | 208847_s_at | 0.4774 | 0.3688 | |
| GSE20347 | ADH5 | 128 | 208847_s_at | 0.6067 | 0.0001 | |
| GSE23400 | ADH5 | 128 | 208847_s_at | 0.4304 | 0.0000 | |
| GSE26886 | ADH5 | 128 | 208847_s_at | 0.5915 | 0.0004 | |
| GSE29001 | ADH5 | 128 | 208847_s_at | 0.7358 | 0.0012 | |
| GSE38129 | ADH5 | 128 | 208847_s_at | 0.4217 | 0.0060 | |
| GSE45670 | ADH5 | 128 | 208847_s_at | -0.1680 | 0.2023 | |
| GSE53622 | ADH5 | 128 | 75720 | -0.3552 | 0.0040 | |
| GSE53624 | ADH5 | 128 | 75720 | -0.3879 | 0.0039 | |
| GSE63941 | ADH5 | 128 | 208847_s_at | -0.8174 | 0.0324 | |
| GSE77861 | ADH5 | 128 | 208847_s_at | 0.4845 | 0.1728 | |
| GSE97050 | ADH5 | 128 | A_23_P18692 | -0.6855 | 0.1321 | |
| SRP007169 | ADH5 | 128 | RNAseq | 1.0685 | 0.0295 | |
| SRP008496 | ADH5 | 128 | RNAseq | 0.8414 | 0.0036 | |
| SRP064894 | ADH5 | 128 | RNAseq | -0.3782 | 0.0158 | |
| SRP133303 | ADH5 | 128 | RNAseq | 0.0937 | 0.6953 | |
| SRP159526 | ADH5 | 128 | RNAseq | -0.1663 | 0.5919 | |
| SRP193095 | ADH5 | 128 | RNAseq | 0.1048 | 0.4782 | |
| SRP219564 | ADH5 | 128 | RNAseq | -0.7393 | 0.1888 | |
| TCGA | ADH5 | 128 | RNAseq | -0.0272 | 0.5812 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ADH5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ADH5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADH5 | 128 | 0 | 13 | 17 | |
| GSE20123 | ADH5 | 128 | 0 | 13 | 17 | |
| GSE43470 | ADH5 | 128 | 0 | 14 | 29 | |
| GSE46452 | ADH5 | 128 | 1 | 36 | 22 | |
| GSE47630 | ADH5 | 128 | 0 | 20 | 20 | |
| GSE54993 | ADH5 | 128 | 9 | 0 | 61 | |
| GSE54994 | ADH5 | 128 | 1 | 11 | 41 | |
| GSE60625 | ADH5 | 128 | 0 | 3 | 8 | |
| GSE74703 | ADH5 | 128 | 0 | 12 | 24 | |
| GSE74704 | ADH5 | 128 | 0 | 6 | 14 | |
| TCGA | ADH5 | 128 | 8 | 41 | 47 |
Total number of gains: 19; Total number of losses: 169; Total Number of normals: 300.
Somatic mutations of ADH5:
Generating mutation plots.
Highly correlated genes for ADH5:
Showing top 20/1111 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADH5 | LSM10 | 0.838716 | 3 | 0 | 3 |
| ADH5 | CENPV | 0.778053 | 4 | 0 | 4 |
| ADH5 | TATDN1 | 0.769199 | 3 | 0 | 3 |
| ADH5 | COMMD7 | 0.764321 | 3 | 0 | 3 |
| ADH5 | CHCHD6 | 0.763221 | 3 | 0 | 3 |
| ADH5 | TCTN1 | 0.755023 | 3 | 0 | 3 |
| ADH5 | ZNF689 | 0.754635 | 3 | 0 | 3 |
| ADH5 | DOCK7 | 0.750722 | 5 | 0 | 5 |
| ADH5 | DHRSX | 0.749535 | 3 | 0 | 3 |
| ADH5 | DNAJC18 | 0.74149 | 3 | 0 | 3 |
| ADH5 | RP9 | 0.740895 | 3 | 0 | 3 |
| ADH5 | BCL7C | 0.740314 | 3 | 0 | 3 |
| ADH5 | RNF34 | 0.73202 | 5 | 0 | 5 |
| ADH5 | LAMTOR4 | 0.730684 | 3 | 0 | 3 |
| ADH5 | LNP1 | 0.728895 | 3 | 0 | 3 |
| ADH5 | C12orf57 | 0.72695 | 4 | 0 | 4 |
| ADH5 | ZSCAN21 | 0.724655 | 4 | 0 | 4 |
| ADH5 | TCEAL6 | 0.722842 | 3 | 0 | 3 |
| ADH5 | RUNDC1 | 0.72273 | 3 | 0 | 3 |
| ADH5 | STAT5B | 0.718131 | 3 | 0 | 3 |
For details and further investigation, click here
