| Full name: coiled-coil-helix-coiled-coil-helix domain containing 6 | Alias Symbol: MGC13016|PPP1R23|CHCM1|Mic25|MICOS25 | ||
| Type: protein-coding gene | Cytoband: 3q21.3 | ||
| Entrez ID: 84303 | HGNC ID: HGNC:28184 | Ensembl Gene: ENSG00000159685 | OMIM ID: 615634 |
| Drug and gene relationship at DGIdb | |||
Expression of CHCHD6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHCHD6 | 84303 | 224462_s_at | 0.3153 | 0.5482 | |
| GSE26886 | CHCHD6 | 84303 | 224462_s_at | 0.8525 | 0.0001 | |
| GSE45670 | CHCHD6 | 84303 | 224462_s_at | 0.1845 | 0.2111 | |
| GSE53622 | CHCHD6 | 84303 | 57381 | 0.3013 | 0.0064 | |
| GSE53624 | CHCHD6 | 84303 | 57381 | 0.3759 | 0.0019 | |
| GSE63941 | CHCHD6 | 84303 | 224462_s_at | 1.0034 | 0.0357 | |
| GSE77861 | CHCHD6 | 84303 | 224462_s_at | 0.1217 | 0.6818 | |
| GSE97050 | CHCHD6 | 84303 | A_33_P3235975 | 0.0330 | 0.9152 | |
| SRP007169 | CHCHD6 | 84303 | RNAseq | 0.1178 | 0.8561 | |
| SRP008496 | CHCHD6 | 84303 | RNAseq | 0.6438 | 0.1348 | |
| SRP064894 | CHCHD6 | 84303 | RNAseq | 0.9548 | 0.0218 | |
| SRP133303 | CHCHD6 | 84303 | RNAseq | 0.7226 | 0.0012 | |
| SRP159526 | CHCHD6 | 84303 | RNAseq | 0.8659 | 0.0277 | |
| SRP193095 | CHCHD6 | 84303 | RNAseq | 0.5321 | 0.0001 | |
| SRP219564 | CHCHD6 | 84303 | RNAseq | 0.5628 | 0.1848 | |
| TCGA | CHCHD6 | 84303 | RNAseq | 0.1115 | 0.2949 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by CHCHD6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CHCHD6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHCHD6 | 84303 | 17 | 0 | 13 | |
| GSE20123 | CHCHD6 | 84303 | 17 | 0 | 13 | |
| GSE43470 | CHCHD6 | 84303 | 19 | 0 | 24 | |
| GSE46452 | CHCHD6 | 84303 | 14 | 5 | 40 | |
| GSE47630 | CHCHD6 | 84303 | 17 | 4 | 19 | |
| GSE54993 | CHCHD6 | 84303 | 2 | 7 | 61 | |
| GSE54994 | CHCHD6 | 84303 | 31 | 3 | 19 | |
| GSE60625 | CHCHD6 | 84303 | 0 | 6 | 5 | |
| GSE74703 | CHCHD6 | 84303 | 17 | 0 | 19 | |
| GSE74704 | CHCHD6 | 84303 | 13 | 0 | 7 | |
| TCGA | CHCHD6 | 84303 | 55 | 6 | 35 |
Total number of gains: 202; Total number of losses: 31; Total Number of normals: 255.
Somatic mutations of CHCHD6:
Generating mutation plots.
Highly correlated genes for CHCHD6:
Showing top 20/911 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHCHD6 | LRRC47 | 0.851843 | 3 | 0 | 3 |
| CHCHD6 | TXLNG | 0.820584 | 3 | 0 | 3 |
| CHCHD6 | ARL6IP4 | 0.812232 | 3 | 0 | 3 |
| CHCHD6 | NOL9 | 0.810515 | 3 | 0 | 3 |
| CHCHD6 | ZNF766 | 0.785559 | 4 | 0 | 4 |
| CHCHD6 | MEAF6 | 0.780337 | 3 | 0 | 3 |
| CHCHD6 | GUSB | 0.780237 | 3 | 0 | 3 |
| CHCHD6 | CASKIN2 | 0.779909 | 3 | 0 | 3 |
| CHCHD6 | TTC30B | 0.774801 | 4 | 0 | 4 |
| CHCHD6 | WDR25 | 0.774455 | 3 | 0 | 3 |
| CHCHD6 | DEXI | 0.771819 | 3 | 0 | 3 |
| CHCHD6 | TTLL1 | 0.766082 | 3 | 0 | 3 |
| CHCHD6 | PIK3R3 | 0.76593 | 3 | 0 | 3 |
| CHCHD6 | KCTD2 | 0.765529 | 3 | 0 | 3 |
| CHCHD6 | QTRT1 | 0.764522 | 5 | 0 | 5 |
| CHCHD6 | UBIAD1 | 0.763776 | 4 | 0 | 4 |
| CHCHD6 | ADH5 | 0.763221 | 3 | 0 | 3 |
| CHCHD6 | EIF2B1 | 0.761489 | 3 | 0 | 3 |
| CHCHD6 | DBN1 | 0.756984 | 3 | 0 | 3 |
| CHCHD6 | UBR7 | 0.756477 | 3 | 0 | 3 |
For details and further investigation, click here
