| Full name: signal transducer and activator of transcription 5B | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 17q21.2 | ||
| Entrez ID: 6777 | HGNC ID: HGNC:11367 | Ensembl Gene: ENSG00000173757 | OMIM ID: 604260 |
| Drug and gene relationship at DGIdb | |||
STAT5B involved pathways:
Expression of STAT5B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | STAT5B | 6777 | 212549_at | -0.2149 | 0.6478 | |
| GSE20347 | STAT5B | 6777 | 212549_at | -0.0462 | 0.7660 | |
| GSE23400 | STAT5B | 6777 | 212549_at | -0.0688 | 0.3127 | |
| GSE26886 | STAT5B | 6777 | 212549_at | 0.2667 | 0.1576 | |
| GSE29001 | STAT5B | 6777 | 212549_at | -0.1686 | 0.5040 | |
| GSE38129 | STAT5B | 6777 | 212549_at | -0.2729 | 0.1245 | |
| GSE45670 | STAT5B | 6777 | 212549_at | -0.3296 | 0.0230 | |
| GSE53622 | STAT5B | 6777 | 102085 | -0.5410 | 0.0000 | |
| GSE53624 | STAT5B | 6777 | 102085 | -0.3519 | 0.0000 | |
| GSE63941 | STAT5B | 6777 | 212549_at | 0.0925 | 0.8177 | |
| GSE77861 | STAT5B | 6777 | 212549_at | 0.3333 | 0.0479 | |
| GSE97050 | STAT5B | 6777 | A_33_P3380867 | -0.2046 | 0.5541 | |
| SRP007169 | STAT5B | 6777 | RNAseq | 0.4403 | 0.2852 | |
| SRP008496 | STAT5B | 6777 | RNAseq | 0.3455 | 0.1483 | |
| SRP064894 | STAT5B | 6777 | RNAseq | 0.0143 | 0.9230 | |
| SRP133303 | STAT5B | 6777 | RNAseq | -0.1971 | 0.2649 | |
| SRP159526 | STAT5B | 6777 | RNAseq | -0.0924 | 0.6252 | |
| SRP193095 | STAT5B | 6777 | RNAseq | 0.3287 | 0.0020 | |
| SRP219564 | STAT5B | 6777 | RNAseq | 0.0028 | 0.9933 | |
| TCGA | STAT5B | 6777 | RNAseq | -0.1954 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by STAT5B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of STAT5B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | STAT5B | 6777 | 6 | 2 | 22 | |
| GSE20123 | STAT5B | 6777 | 6 | 2 | 22 | |
| GSE43470 | STAT5B | 6777 | 1 | 2 | 40 | |
| GSE46452 | STAT5B | 6777 | 34 | 0 | 25 | |
| GSE47630 | STAT5B | 6777 | 8 | 1 | 31 | |
| GSE54993 | STAT5B | 6777 | 3 | 4 | 63 | |
| GSE54994 | STAT5B | 6777 | 8 | 5 | 40 | |
| GSE60625 | STAT5B | 6777 | 4 | 0 | 7 | |
| GSE74703 | STAT5B | 6777 | 1 | 1 | 34 | |
| GSE74704 | STAT5B | 6777 | 4 | 1 | 15 | |
| TCGA | STAT5B | 6777 | 23 | 6 | 67 |
Total number of gains: 98; Total number of losses: 24; Total Number of normals: 366.
Somatic mutations of STAT5B:
Generating mutation plots.
Highly correlated genes for STAT5B:
Showing top 20/958 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| STAT5B | PGRMC1 | 0.810518 | 3 | 0 | 3 |
| STAT5B | RAPGEF1 | 0.807267 | 3 | 0 | 3 |
| STAT5B | EID3 | 0.800486 | 3 | 0 | 3 |
| STAT5B | TNFSF12 | 0.769571 | 3 | 0 | 3 |
| STAT5B | RTN2 | 0.767922 | 3 | 0 | 3 |
| STAT5B | RNF19A | 0.758386 | 3 | 0 | 3 |
| STAT5B | KIAA1324L | 0.758053 | 3 | 0 | 3 |
| STAT5B | HLTF | 0.752197 | 3 | 0 | 3 |
| STAT5B | PLIN4 | 0.748416 | 3 | 0 | 3 |
| STAT5B | ZNF518B | 0.74241 | 3 | 0 | 3 |
| STAT5B | MSI2 | 0.742159 | 4 | 0 | 4 |
| STAT5B | TLN2 | 0.738535 | 3 | 0 | 3 |
| STAT5B | FAM50A | 0.738247 | 4 | 0 | 4 |
| STAT5B | C5orf22 | 0.738138 | 3 | 0 | 3 |
| STAT5B | ECSCR | 0.733045 | 4 | 0 | 4 |
| STAT5B | NAPEPLD | 0.732956 | 3 | 0 | 3 |
| STAT5B | DEXI | 0.732675 | 3 | 0 | 3 |
| STAT5B | CASKIN2 | 0.731605 | 3 | 0 | 3 |
| STAT5B | DCHS1 | 0.726696 | 6 | 0 | 6 |
| STAT5B | ZNF548 | 0.72478 | 3 | 0 | 3 |
For details and further investigation, click here
