LAMTOR4

 

Full name: late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 Alias Symbol: 
Type: protein-coding gene Cytoband: 7q22.1
Entrez ID: 389541 HGNC ID: HGNC:33772 Ensembl Gene: ENSG00000188186 OMIM ID: 
Drug and gene relationship at DGIdb
Screen Evidence:

 

LAMTOR4 involved pathways:

KEGG pathway Description View
hsa04150mTOR signaling pathway

 

Expression of LAMTOR4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 LAMTOR4 389541 224890_s_at 0.4568 0.4026
GSE26886 LAMTOR4 389541 224890_s_at 1.3073 0.0002
GSE45670 LAMTOR4 389541 224890_s_at 0.4112 0.0434
GSE53622 LAMTOR4 389541 19671 0.4389 0.0000
GSE53624 LAMTOR4 389541 19671 0.8685 0.0000
GSE63941 LAMTOR4 389541 224890_s_at -0.1932 0.7519
GSE77861 LAMTOR4 389541 224890_s_at 0.3902 0.1145
SRP007169 LAMTOR4 389541 RNAseq 0.6719 0.1728
SRP008496 LAMTOR4 389541 RNAseq 0.8171 0.0281
SRP064894 LAMTOR4 389541 RNAseq 0.4812 0.1832
SRP133303 LAMTOR4 389541 RNAseq 0.4348 0.0000
SRP159526 LAMTOR4 389541 RNAseq 0.9344 0.0288
SRP193095 LAMTOR4 389541 RNAseq 0.2837 0.1238
SRP219564 LAMTOR4 389541 RNAseq 0.7835 0.0815

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by LAMTOR4 expression:

 

GSE53622GSE53624

 

Note: Click image to view full size file.  

Copy number change of LAMTOR4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 LAMTOR4 389541 13 0 17
GSE20123 LAMTOR4 389541 13 0 17
GSE43470 LAMTOR4 389541 6 2 35
GSE46452 LAMTOR4 389541 11 1 47
GSE47630 LAMTOR4 389541 7 3 30
GSE54993 LAMTOR4 389541 1 9 60
GSE54994 LAMTOR4 389541 15 3 35
GSE60625 LAMTOR4 389541 0 0 11
GSE74703 LAMTOR4 389541 6 1 29
GSE74704 LAMTOR4 389541 9 0 11
TCGA LAMTOR4 389541 52 6 38

Total number of gains: 133; Total number of losses: 25; Total Number of normals: 330.  

 

Somatic mutations of LAMTOR4:

 

Generating mutation plots.

 

Highly correlated genes for LAMTOR4:

 

Showing top 20/863 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
LAMTOR4LSM40.793153404
LAMTOR4PRR150.762152303
LAMTOR4MCM70.761579606
LAMTOR4ZNHIT10.754958505
LAMTOR4POP70.753223606
LAMTOR4PELI20.744376303
LAMTOR4MAD2L20.743489505
LAMTOR4POLR2J0.736836606
LAMTOR4ADH50.730684303
LAMTOR4ECSIT0.715499404
LAMTOR4CHEK20.710944505
LAMTOR4TRIO0.709947303
LAMTOR4NDUFB90.704598505
LAMTOR4MEPCE0.701556706
LAMTOR4TAF60.700881605
LAMTOR4GPRC5C0.69784303
LAMTOR4HEY10.695514606
LAMTOR4ARL30.68587303
LAMTOR4SNHG190.685116303
LAMTOR4AP3M20.682204505

For details and further investigation, click here