| Full name: adrenoceptor alpha 2A | Alias Symbol: ADRAR | ||
| Type: protein-coding gene | Cytoband: 10q25.2 | ||
| Entrez ID: 150 | HGNC ID: HGNC:281 | Ensembl Gene: ENSG00000150594 | OMIM ID: 104210 |
| Drug and gene relationship at DGIdb | |||
ADRA2A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04022 | cGMP-PKG signaling pathway |
Expression of ADRA2A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADRA2A | 150 | 209869_at | -0.7969 | 0.1072 | |
| GSE20347 | ADRA2A | 150 | 209869_at | -0.1153 | 0.2724 | |
| GSE23400 | ADRA2A | 150 | 209869_at | -0.1092 | 0.0388 | |
| GSE26886 | ADRA2A | 150 | 209869_at | -0.3247 | 0.4706 | |
| GSE29001 | ADRA2A | 150 | 209869_at | -0.4612 | 0.0831 | |
| GSE38129 | ADRA2A | 150 | 209869_at | -0.4771 | 0.0623 | |
| GSE45670 | ADRA2A | 150 | 209869_at | -1.1240 | 0.0003 | |
| GSE53622 | ADRA2A | 150 | 7203 | -0.0613 | 0.2244 | |
| GSE53624 | ADRA2A | 150 | 7203 | -0.1247 | 0.0532 | |
| GSE63941 | ADRA2A | 150 | 209869_at | 0.2671 | 0.3349 | |
| GSE77861 | ADRA2A | 150 | 209869_at | -0.0954 | 0.4750 | |
| GSE97050 | ADRA2A | 150 | A_23_P138706 | -0.1181 | 0.5795 | |
| SRP064894 | ADRA2A | 150 | RNAseq | 0.1474 | 0.7320 | |
| SRP133303 | ADRA2A | 150 | RNAseq | -0.7970 | 0.0846 | |
| SRP159526 | ADRA2A | 150 | RNAseq | -1.2199 | 0.0874 | |
| SRP219564 | ADRA2A | 150 | RNAseq | 2.0643 | 0.0237 | |
| TCGA | ADRA2A | 150 | RNAseq | -0.0951 | 0.7398 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by ADRA2A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ADRA2A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADRA2A | 150 | 1 | 9 | 20 | |
| GSE20123 | ADRA2A | 150 | 1 | 8 | 21 | |
| GSE43470 | ADRA2A | 150 | 0 | 7 | 36 | |
| GSE46452 | ADRA2A | 150 | 0 | 11 | 48 | |
| GSE47630 | ADRA2A | 150 | 2 | 14 | 24 | |
| GSE54993 | ADRA2A | 150 | 8 | 0 | 62 | |
| GSE54994 | ADRA2A | 150 | 1 | 10 | 42 | |
| GSE60625 | ADRA2A | 150 | 0 | 0 | 11 | |
| GSE74703 | ADRA2A | 150 | 0 | 5 | 31 | |
| GSE74704 | ADRA2A | 150 | 1 | 4 | 15 | |
| TCGA | ADRA2A | 150 | 4 | 29 | 63 |
Total number of gains: 18; Total number of losses: 97; Total Number of normals: 373.
Somatic mutations of ADRA2A:
Generating mutation plots.
Highly correlated genes for ADRA2A:
Showing top 20/292 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADRA2A | SEMA5B | 0.767734 | 3 | 0 | 3 |
| ADRA2A | C16orf89 | 0.747668 | 3 | 0 | 3 |
| ADRA2A | SHISA8 | 0.737902 | 3 | 0 | 3 |
| ADRA2A | GPR146 | 0.726835 | 3 | 0 | 3 |
| ADRA2A | SIRPD | 0.713405 | 4 | 0 | 3 |
| ADRA2A | ANKRD33 | 0.711612 | 4 | 0 | 3 |
| ADRA2A | SPN | 0.71117 | 3 | 0 | 3 |
| ADRA2A | PAX6 | 0.709984 | 3 | 0 | 3 |
| ADRA2A | TESC | 0.706853 | 5 | 0 | 5 |
| ADRA2A | ZNF524 | 0.6971 | 3 | 0 | 3 |
| ADRA2A | C22orf23 | 0.694816 | 3 | 0 | 3 |
| ADRA2A | DCLK1 | 0.692162 | 4 | 0 | 4 |
| ADRA2A | RETN | 0.692063 | 3 | 0 | 3 |
| ADRA2A | C20orf173 | 0.691897 | 3 | 0 | 3 |
| ADRA2A | FGD5 | 0.687765 | 3 | 0 | 3 |
| ADRA2A | TTC7A | 0.683628 | 3 | 0 | 3 |
| ADRA2A | YY2 | 0.682452 | 3 | 0 | 3 |
| ADRA2A | C1QL2 | 0.681322 | 3 | 0 | 3 |
| ADRA2A | PLXDC2 | 0.679812 | 3 | 0 | 3 |
| ADRA2A | NUDT13 | 0.677171 | 4 | 0 | 3 |
For details and further investigation, click here
