| Full name: paired box 6 | Alias Symbol: D11S812E|AN|WAGR | ||
| Type: protein-coding gene | Cytoband: 11p13 | ||
| Entrez ID: 5080 | HGNC ID: HGNC:8620 | Ensembl Gene: ENSG00000007372 | OMIM ID: 607108 |
| Drug and gene relationship at DGIdb | |||
PAX6 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04950 | Maturity onset diabetes of the young |
Expression of PAX6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PAX6 | 5080 | 205646_s_at | 0.5252 | 0.2138 | |
| GSE20347 | PAX6 | 5080 | 205646_s_at | 0.4090 | 0.0599 | |
| GSE23400 | PAX6 | 5080 | 205646_s_at | 0.0858 | 0.1923 | |
| GSE26886 | PAX6 | 5080 | 205646_s_at | 0.7459 | 0.0016 | |
| GSE29001 | PAX6 | 5080 | 205646_s_at | 0.6422 | 0.0117 | |
| GSE38129 | PAX6 | 5080 | 205646_s_at | 0.4591 | 0.0268 | |
| GSE45670 | PAX6 | 5080 | 205646_s_at | 0.3966 | 0.2205 | |
| GSE53622 | PAX6 | 5080 | 2081 | 0.1341 | 0.1029 | |
| GSE53624 | PAX6 | 5080 | 2081 | 0.0181 | 0.8586 | |
| GSE63941 | PAX6 | 5080 | 205646_s_at | 1.2163 | 0.2105 | |
| GSE77861 | PAX6 | 5080 | 205646_s_at | 0.1394 | 0.4710 | |
| GSE97050 | PAX6 | 5080 | A_33_P3234303 | -0.1848 | 0.3815 | |
| SRP133303 | PAX6 | 5080 | RNAseq | 1.8714 | 0.0050 | |
| SRP159526 | PAX6 | 5080 | RNAseq | 5.0835 | 0.0000 | |
| TCGA | PAX6 | 5080 | RNAseq | 0.0139 | 0.9442 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by PAX6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PAX6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PAX6 | 5080 | 1 | 9 | 20 | |
| GSE20123 | PAX6 | 5080 | 1 | 8 | 21 | |
| GSE43470 | PAX6 | 5080 | 2 | 4 | 37 | |
| GSE46452 | PAX6 | 5080 | 8 | 5 | 46 | |
| GSE47630 | PAX6 | 5080 | 3 | 10 | 27 | |
| GSE54993 | PAX6 | 5080 | 3 | 0 | 67 | |
| GSE54994 | PAX6 | 5080 | 4 | 10 | 39 | |
| GSE60625 | PAX6 | 5080 | 0 | 0 | 11 | |
| GSE74703 | PAX6 | 5080 | 2 | 2 | 32 | |
| GSE74704 | PAX6 | 5080 | 0 | 7 | 13 | |
| TCGA | PAX6 | 5080 | 12 | 24 | 60 |
Total number of gains: 36; Total number of losses: 79; Total Number of normals: 373.
Somatic mutations of PAX6:
Generating mutation plots.
Highly correlated genes for PAX6:
Showing top 20/382 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PAX6 | YY2 | 0.899204 | 3 | 0 | 3 |
| PAX6 | CPLX2 | 0.879005 | 3 | 0 | 3 |
| PAX6 | GPR182 | 0.874781 | 3 | 0 | 3 |
| PAX6 | GRIK4 | 0.848382 | 3 | 0 | 3 |
| PAX6 | SLC22A12 | 0.848306 | 3 | 0 | 3 |
| PAX6 | STAC3 | 0.841686 | 3 | 0 | 3 |
| PAX6 | TSSK3 | 0.840529 | 3 | 0 | 3 |
| PAX6 | PRSS38 | 0.840429 | 3 | 0 | 3 |
| PAX6 | C2orf72 | 0.839308 | 3 | 0 | 3 |
| PAX6 | C1QL2 | 0.836939 | 3 | 0 | 3 |
| PAX6 | OR2T27 | 0.835541 | 3 | 0 | 3 |
| PAX6 | C9orf153 | 0.834856 | 3 | 0 | 3 |
| PAX6 | DCDC1 | 0.832179 | 3 | 0 | 3 |
| PAX6 | BMF | 0.831298 | 3 | 0 | 3 |
| PAX6 | BBC3 | 0.829924 | 3 | 0 | 3 |
| PAX6 | KRTAP4-8 | 0.828935 | 3 | 0 | 3 |
| PAX6 | LRIT1 | 0.828446 | 3 | 0 | 3 |
| PAX6 | STRC | 0.827739 | 3 | 0 | 3 |
| PAX6 | OR2B11 | 0.827112 | 3 | 0 | 3 |
| PAX6 | DEFB121 | 0.822894 | 3 | 0 | 3 |
For details and further investigation, click here
