| Full name: tetratricopeptide repeat domain 7A | Alias Symbol: KIAA1140 | ||
| Type: protein-coding gene | Cytoband: 2p21 | ||
| Entrez ID: 57217 | HGNC ID: HGNC:19750 | Ensembl Gene: ENSG00000068724 | OMIM ID: 609332 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TTC7A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TTC7A | 57217 | 224912_at | -0.1362 | 0.7602 | |
| GSE26886 | TTC7A | 57217 | 224912_at | 0.4015 | 0.0059 | |
| GSE45670 | TTC7A | 57217 | 224912_at | -0.2669 | 0.0536 | |
| GSE53622 | TTC7A | 57217 | 59316 | -0.1664 | 0.0024 | |
| GSE53624 | TTC7A | 57217 | 59316 | -0.4219 | 0.0000 | |
| GSE63941 | TTC7A | 57217 | 224912_at | 0.5203 | 0.2354 | |
| GSE77861 | TTC7A | 57217 | 224912_at | -0.2049 | 0.1988 | |
| GSE97050 | TTC7A | 57217 | A_33_P3404651 | -0.0714 | 0.7318 | |
| SRP007169 | TTC7A | 57217 | RNAseq | -1.0043 | 0.0110 | |
| SRP008496 | TTC7A | 57217 | RNAseq | -0.9679 | 0.0001 | |
| SRP064894 | TTC7A | 57217 | RNAseq | -0.4168 | 0.0000 | |
| SRP133303 | TTC7A | 57217 | RNAseq | -0.5761 | 0.0000 | |
| SRP159526 | TTC7A | 57217 | RNAseq | -0.6502 | 0.0042 | |
| SRP193095 | TTC7A | 57217 | RNAseq | -0.1754 | 0.1318 | |
| SRP219564 | TTC7A | 57217 | RNAseq | -0.1677 | 0.5921 | |
| TCGA | TTC7A | 57217 | RNAseq | -0.0270 | 0.5984 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by TTC7A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TTC7A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TTC7A | 57217 | 10 | 1 | 19 | |
| GSE20123 | TTC7A | 57217 | 8 | 1 | 21 | |
| GSE43470 | TTC7A | 57217 | 5 | 0 | 38 | |
| GSE46452 | TTC7A | 57217 | 1 | 4 | 54 | |
| GSE47630 | TTC7A | 57217 | 7 | 0 | 33 | |
| GSE54993 | TTC7A | 57217 | 0 | 5 | 65 | |
| GSE54994 | TTC7A | 57217 | 10 | 0 | 43 | |
| GSE60625 | TTC7A | 57217 | 0 | 3 | 8 | |
| GSE74703 | TTC7A | 57217 | 5 | 0 | 31 | |
| GSE74704 | TTC7A | 57217 | 9 | 1 | 10 | |
| TCGA | TTC7A | 57217 | 35 | 3 | 58 |
Total number of gains: 90; Total number of losses: 18; Total Number of normals: 380.
Somatic mutations of TTC7A:
Generating mutation plots.
Highly correlated genes for TTC7A:
Showing top 20/242 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TTC7A | LRFN3 | 0.821585 | 3 | 0 | 3 |
| TTC7A | PRSS38 | 0.816048 | 3 | 0 | 3 |
| TTC7A | FXYD2 | 0.81398 | 4 | 0 | 4 |
| TTC7A | PAX2 | 0.811906 | 3 | 0 | 3 |
| TTC7A | YY2 | 0.806776 | 3 | 0 | 3 |
| TTC7A | KRTAP6-1 | 0.800993 | 3 | 0 | 3 |
| TTC7A | SPN | 0.789557 | 3 | 0 | 3 |
| TTC7A | PRG3 | 0.789174 | 3 | 0 | 3 |
| TTC7A | GDF7 | 0.784832 | 3 | 0 | 3 |
| TTC7A | MFSD2B | 0.764622 | 3 | 0 | 3 |
| TTC7A | OR2B11 | 0.756603 | 3 | 0 | 3 |
| TTC7A | TEN1 | 0.750348 | 3 | 0 | 3 |
| TTC7A | POLM | 0.743957 | 3 | 0 | 3 |
| TTC7A | CD164L2 | 0.743191 | 3 | 0 | 3 |
| TTC7A | MAP3K10 | 0.74134 | 4 | 0 | 3 |
| TTC7A | OR13G1 | 0.737237 | 3 | 0 | 3 |
| TTC7A | CTU1 | 0.736748 | 3 | 0 | 3 |
| TTC7A | RBM43 | 0.733495 | 3 | 0 | 3 |
| TTC7A | OR10G8 | 0.730716 | 3 | 0 | 3 |
| TTC7A | TPRX1 | 0.730616 | 3 | 0 | 3 |
For details and further investigation, click here
