| Full name: FYVE, RhoGEF and PH domain containing 5 | Alias Symbol: ZFYVE23|FLJ39957|FLJ00274 | ||
| Type: protein-coding gene | Cytoband: 3p25.1 | ||
| Entrez ID: 152273 | HGNC ID: HGNC:19117 | Ensembl Gene: ENSG00000154783 | OMIM ID: 614788 |
| Drug and gene relationship at DGIdb | |||
Expression of FGD5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FGD5 | 152273 | 226985_at | -0.0492 | 0.9189 | |
| GSE26886 | FGD5 | 152273 | 226985_at | 0.2926 | 0.1176 | |
| GSE45670 | FGD5 | 152273 | 226985_at | -1.0094 | 0.0002 | |
| GSE53622 | FGD5 | 152273 | 73296 | -0.0446 | 0.7005 | |
| GSE53624 | FGD5 | 152273 | 73296 | -0.0667 | 0.4494 | |
| GSE63941 | FGD5 | 152273 | 226984_at | 0.1061 | 0.7641 | |
| GSE77861 | FGD5 | 152273 | 226984_at | 0.0944 | 0.4073 | |
| GSE97050 | FGD5 | 152273 | A_33_P3364180 | -0.2601 | 0.4886 | |
| SRP007169 | FGD5 | 152273 | RNAseq | 1.7855 | 0.0216 | |
| SRP064894 | FGD5 | 152273 | RNAseq | 0.4025 | 0.2001 | |
| SRP133303 | FGD5 | 152273 | RNAseq | -0.5059 | 0.0204 | |
| SRP159526 | FGD5 | 152273 | RNAseq | 0.3456 | 0.3689 | |
| SRP193095 | FGD5 | 152273 | RNAseq | 0.5865 | 0.0186 | |
| SRP219564 | FGD5 | 152273 | RNAseq | 0.1993 | 0.6657 | |
| TCGA | FGD5 | 152273 | RNAseq | -0.4186 | 0.0031 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by FGD5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FGD5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FGD5 | 152273 | 1 | 19 | 10 | |
| GSE20123 | FGD5 | 152273 | 1 | 19 | 10 | |
| GSE43470 | FGD5 | 152273 | 0 | 21 | 22 | |
| GSE46452 | FGD5 | 152273 | 2 | 17 | 40 | |
| GSE47630 | FGD5 | 152273 | 2 | 23 | 15 | |
| GSE54993 | FGD5 | 152273 | 6 | 1 | 63 | |
| GSE54994 | FGD5 | 152273 | 1 | 32 | 20 | |
| GSE60625 | FGD5 | 152273 | 5 | 0 | 6 | |
| GSE74703 | FGD5 | 152273 | 0 | 17 | 19 | |
| GSE74704 | FGD5 | 152273 | 1 | 12 | 7 | |
| TCGA | FGD5 | 152273 | 2 | 68 | 26 |
Total number of gains: 21; Total number of losses: 229; Total Number of normals: 238.
Somatic mutations of FGD5:
Generating mutation plots.
Highly correlated genes for FGD5:
Showing top 20/98 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FGD5 | PRKCB | 0.724293 | 3 | 0 | 3 |
| FGD5 | SNAP91 | 0.724087 | 3 | 0 | 3 |
| FGD5 | BTK | 0.71457 | 4 | 0 | 4 |
| FGD5 | TM6SF1 | 0.702952 | 4 | 0 | 3 |
| FGD5 | ADRA2A | 0.687765 | 3 | 0 | 3 |
| FGD5 | PLCL2 | 0.68117 | 5 | 0 | 5 |
| FGD5 | TDRD10 | 0.673321 | 4 | 0 | 4 |
| FGD5 | HSPA12B | 0.673245 | 4 | 0 | 3 |
| FGD5 | LINC01279 | 0.670176 | 3 | 0 | 3 |
| FGD5 | NDNF | 0.663245 | 4 | 0 | 4 |
| FGD5 | P2RY14 | 0.652219 | 3 | 0 | 3 |
| FGD5 | NTRK1 | 0.64724 | 3 | 0 | 3 |
| FGD5 | PTGDS | 0.646103 | 5 | 0 | 4 |
| FGD5 | DCLK1 | 0.643392 | 5 | 0 | 4 |
| FGD5 | ENTPD1 | 0.641894 | 6 | 0 | 5 |
| FGD5 | CRYGA | 0.640309 | 3 | 0 | 3 |
| FGD5 | HEBP1 | 0.638433 | 3 | 0 | 3 |
| FGD5 | SEMA3B | 0.637301 | 4 | 0 | 3 |
| FGD5 | FXYD6 | 0.634785 | 6 | 0 | 5 |
| FGD5 | VCAM1 | 0.633747 | 5 | 0 | 4 |
For details and further investigation, click here
