| Full name: doublecortin like kinase 1 | Alias Symbol: KIAA0369|DCLK|DCDC3A | ||
| Type: protein-coding gene | Cytoband: 13q13.3 | ||
| Entrez ID: 9201 | HGNC ID: HGNC:2700 | Ensembl Gene: ENSG00000133083 | OMIM ID: 604742 |
| Drug and gene relationship at DGIdb | |||
Expression of DCLK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DCLK1 | 9201 | 229800_at | -1.5574 | 0.2294 | |
| GSE20347 | DCLK1 | 9201 | 205399_at | -0.0964 | 0.6600 | |
| GSE23400 | DCLK1 | 9201 | 205399_at | -0.3799 | 0.0019 | |
| GSE26886 | DCLK1 | 9201 | 205399_at | 1.3776 | 0.0437 | |
| GSE29001 | DCLK1 | 9201 | 205399_at | -0.3016 | 0.5646 | |
| GSE38129 | DCLK1 | 9201 | 205399_at | -0.7602 | 0.0411 | |
| GSE45670 | DCLK1 | 9201 | 205399_at | -2.7255 | 0.0000 | |
| GSE53622 | DCLK1 | 9201 | 20020 | -2.0671 | 0.0000 | |
| GSE53624 | DCLK1 | 9201 | 20020 | -2.2457 | 0.0000 | |
| GSE63941 | DCLK1 | 9201 | 205399_at | -0.6012 | 0.5974 | |
| GSE77861 | DCLK1 | 9201 | 229800_at | 0.2273 | 0.0707 | |
| GSE97050 | DCLK1 | 9201 | A_33_P3302777 | -0.7698 | 0.1588 | |
| SRP007169 | DCLK1 | 9201 | RNAseq | 2.8147 | 0.0013 | |
| SRP008496 | DCLK1 | 9201 | RNAseq | 2.9197 | 0.0001 | |
| SRP064894 | DCLK1 | 9201 | RNAseq | -0.2156 | 0.6750 | |
| SRP133303 | DCLK1 | 9201 | RNAseq | -1.5072 | 0.0001 | |
| SRP159526 | DCLK1 | 9201 | RNAseq | -0.4764 | 0.3525 | |
| SRP219564 | DCLK1 | 9201 | RNAseq | -0.4145 | 0.6412 | |
| TCGA | DCLK1 | 9201 | RNAseq | -0.7485 | 0.0045 |
Upregulated datasets: 3; Downregulated datasets: 4.
Survival by DCLK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DCLK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DCLK1 | 9201 | 0 | 16 | 14 | |
| GSE20123 | DCLK1 | 9201 | 0 | 15 | 15 | |
| GSE43470 | DCLK1 | 9201 | 2 | 13 | 28 | |
| GSE46452 | DCLK1 | 9201 | 0 | 33 | 26 | |
| GSE47630 | DCLK1 | 9201 | 2 | 27 | 11 | |
| GSE54993 | DCLK1 | 9201 | 12 | 2 | 56 | |
| GSE54994 | DCLK1 | 9201 | 1 | 17 | 35 | |
| GSE60625 | DCLK1 | 9201 | 0 | 3 | 8 | |
| GSE74703 | DCLK1 | 9201 | 2 | 10 | 24 | |
| GSE74704 | DCLK1 | 9201 | 0 | 12 | 8 | |
| TCGA | DCLK1 | 9201 | 7 | 40 | 49 |
Total number of gains: 26; Total number of losses: 188; Total Number of normals: 274.
Somatic mutations of DCLK1:
Generating mutation plots.
Highly correlated genes for DCLK1:
Showing top 20/641 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DCLK1 | OR10G8 | 0.785978 | 3 | 0 | 3 |
| DCLK1 | ANGPTL1 | 0.771463 | 4 | 0 | 4 |
| DCLK1 | MYZAP | 0.757144 | 3 | 0 | 3 |
| DCLK1 | CCDC80 | 0.755706 | 3 | 0 | 3 |
| DCLK1 | TGFBR3 | 0.754351 | 7 | 0 | 7 |
| DCLK1 | AQP1 | 0.746404 | 6 | 0 | 6 |
| DCLK1 | CSTL1 | 0.745234 | 3 | 0 | 3 |
| DCLK1 | APOD | 0.74328 | 8 | 0 | 8 |
| DCLK1 | ASPA | 0.741375 | 7 | 0 | 6 |
| DCLK1 | SGCE | 0.739885 | 6 | 0 | 6 |
| DCLK1 | MAMDC2 | 0.736411 | 4 | 0 | 4 |
| DCLK1 | TCF21 | 0.732654 | 6 | 0 | 6 |
| DCLK1 | FGF14 | 0.732198 | 5 | 0 | 4 |
| DCLK1 | LINC01082 | 0.732057 | 4 | 0 | 4 |
| DCLK1 | F10 | 0.72562 | 5 | 0 | 5 |
| DCLK1 | RERGL | 0.721971 | 6 | 0 | 5 |
| DCLK1 | SVEP1 | 0.721621 | 6 | 0 | 6 |
| DCLK1 | RAB9B | 0.72137 | 5 | 0 | 5 |
| DCLK1 | ABI3BP | 0.719969 | 6 | 0 | 6 |
| DCLK1 | ADH1B | 0.718576 | 6 | 0 | 6 |
For details and further investigation, click here
